SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 8 THR A 384
LEU A 380
THR A 319
VAL A 336
 None
 1.09A 1dz9A-5j04A:
undetectable		 1dz9A-5j04A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 8 THR A 384
LEU A 380
THR A 319
VAL A 336
 None
 1.04A 1o76B-5j04A:
undetectable		 1o76B-5j04A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 7 TYR A 403
ILE A 171
PRO A 173
ALA A 182
 None
 1.05A 1oniD-5j04A:
undetectable
1oniE-5j04A:
undetectable		 1oniD-5j04A:
19.61
1oniE-5j04A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 8 THR A 384
LEU A 380
THR A 319
VAL A 336
 None
 1.14A 1uyuA-5j04A:
undetectable		 1uyuA-5j04A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 8 THR A 384
LEU A 380
THR A 319
VAL A 336
 None
 1.12A 1uyuB-5j04A:
undetectable		 1uyuB-5j04A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 4 LEU A 274
SER A 249
LEU A 311
LEU A 301
 None
 0.87A 1yajA-5j04A:
undetectable		 1yajA-5j04A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 8 LEU A 193
LEU A 223
VAL A 164
GLY A 156
 None
 0.98A 2po5A-5j04A:
undetectable		 2po5A-5j04A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 5 LEU A 274
ILE A 283
ILE A 273
GLY A 289
 None
 0.95A 3bufA-5j04A:
undetectable		 3bufA-5j04A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5j04 ENOLASE
(Synechococcus
elongatus) 		5 / 12 GLY A 289
SER A 250
LEU A 316
LEU A 301
LEU A 305
 None
CA  A 506 ( 4.9A)
None
None
None
 1.36A 3cjtK-5j04A:
undetectable		 3cjtK-5j04A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5j04 ENOLASE
(Synechococcus
elongatus) 		5 / 12 GLN A 291
ASP A 314
ASP A 246
ALA A 248
SER A 249
 None
MG  A 502 ( 3.4A)
MG  A 502 ( 2.9A)
None
None
 1.19A 3d91B-5j04A:
undetectable		 3d91B-5j04A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5j04 ENOLASE
(Synechococcus
elongatus) 		5 / 12 LEU A 301
GLY A 313
GLY A 289
LEU A 316
LEU A 274
 None
 1.12A 3e23A-5j04A:
undetectable		 3e23A-5j04A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5j04 ENOLASE
(Synechococcus
elongatus) 		5 / 12 ASP A  95
LEU A 346
ILE A 353
LEU A 380
LEU A 138
 None
 1.00A 3k2hA-5j04A:
undetectable		 3k2hA-5j04A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5j04 ENOLASE
(Synechococcus
elongatus) 		5 / 9 ALA A  88
LEU A  94
GLN A  91
ALA A 123
SER A 119
 None
 1.38A 3kp6B-5j04A:
undetectable		 3kp6B-5j04A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5j04 ENOLASE
(Synechococcus
elongatus) 		3 / 3 GLU A 371
GLU A  52
ASN A 341
 None
 0.86A 3lp9B-5j04A:
undetectable
3lp9D-5j04A:
undetectable		 3lp9B-5j04A:
18.24
3lp9D-5j04A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 8 ASN A 219
ASP A 165
VAL A 247
LEU A 277
 None
 1.03A 4f8hA-5j04A:
undetectable
4f8hB-5j04A:
undetectable		 4f8hA-5j04A:
22.05
4f8hB-5j04A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 8 ASN A 219
ASP A 165
VAL A 247
LEU A 277
 None
 1.04A 4f8hC-5j04A:
undetectable
4f8hD-5j04A:
undetectable		 4f8hC-5j04A:
22.05
4f8hD-5j04A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 8 ASN A 219
ASP A 165
VAL A 247
LEU A 277
 None
 1.03A 4f8hD-5j04A:
undetectable
4f8hE-5j04A:
undetectable		 4f8hD-5j04A:
22.05
4f8hE-5j04A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 5j04 ENOLASE
(Synechococcus
elongatus) 		5 / 12 GLY A 392
ASN A 152
MET A 151
ILE A 389
LEU A 337
 None
 1.03A 4kosA-5j04A:
undetectable		 4kosA-5j04A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 5j04 ENOLASE
(Synechococcus
elongatus) 		5 / 12 GLY A 392
ASN A 152
MET A 151
SER A 366
LEU A 337
 None
None
None
PEP  A 501 ( 4.5A)
None
 1.14A 4kowA-5j04A:
undetectable		 4kowA-5j04A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 5j04 ENOLASE
(Synechococcus
elongatus) 		5 / 11 GLY A 392
ASN A 152
MET A 151
ILE A 389
LEU A 337
 None
 0.96A 4koyA-5j04A:
undetectable		 4koyA-5j04A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 5 LEU A 146
SER A 178
LEU A 407
LEU A 413
 None
 1.32A 4n09D-5j04A:
undetectable		 4n09D-5j04A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 5 ASN A 162
GLY A 156
ASP A 276
ASP A 165
 None
 1.14A 4n48B-5j04A:
undetectable		 4n48B-5j04A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 4 ASN A 162
GLY A 156
ASP A 276
ASP A 165
 None
 1.03A 4n49A-5j04A:
undetectable		 4n49A-5j04A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 5 LEU A 116
GLU A 348
LEU A 380
HIS A 124
 None
 1.36A 4xi3B-5j04A:
undetectable		 4xi3B-5j04A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 5j04 ENOLASE
(Synechococcus
elongatus) 		4 / 8 PRO A 133
ALA A 143
ILE A 409
ALA A 412
 None
 0.67A 5mvmA-5j04A:
undetectable
5mvmB-5j04A:
undetectable		 5mvmA-5j04A:
11.78
5mvmB-5j04A:
11.78