SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 ILE A 245
ILE A 248
GLY A 208
LEU A 275
TYR A 272
 None
 1.21A 2azyA-5j0aA:
undetectable		 2azyA-5j0aA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.04A 3eeyA-5j0aA:
undetectable		 3eeyA-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.05A 3eeyB-5j0aA:
undetectable		 3eeyB-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.05A 3eeyC-5j0aA:
undetectable		 3eeyC-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.06A 3eeyD-5j0aA:
undetectable		 3eeyD-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.10A 3eeyE-5j0aA:
undetectable		 3eeyE-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.14A 3eeyH-5j0aA:
undetectable		 3eeyH-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.12A 3eeyI-5j0aA:
undetectable		 3eeyI-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.13A 3eeyJ-5j0aA:
undetectable		 3eeyJ-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		4 / 8 VAL A 199
ILE A 184
VAL A 187
GLY A 166
 None
 0.88A 3hjoB-5j0aA:
undetectable		 3hjoB-5j0aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		3 / 3 TYR A 156
LEU A 144
LYS A 145
 None
 0.76A 3sueD-5j0aA:
undetectable		 3sueD-5j0aA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		4 / 8 VAL A  98
ILE A 184
CYH A 185
ASP A 186
 None
 0.68A 3wzeA-5j0aA:
2.4		 3wzeA-5j0aA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 LEU A  89
LEU A  92
ASP A 167
LYS A 169
ASN A 172
ASP A 186
 None
 1.27A 4an2A-5j0aA:
4.3		 4an2A-5j0aA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		4 / 8 SER A 170
GLU A 128
ILE A 127
ASP A 125
 None
 1.07A 4d33A-5j0aA:
undetectable		 4d33A-5j0aA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		4 / 7 SER A 170
GLU A 128
ILE A 127
ASP A 125
 None
 1.12A 4d33B-5j0aA:
undetectable		 4d33B-5j0aA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		4 / 7 GLY A 276
VAL A 218
PRO A 214
GLY A 208
 None
 0.82A 4forA-5j0aA:
undetectable		 4forA-5j0aA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.03A 4pooA-5j0aA:
undetectable		 4pooA-5j0aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ILE A 184
LEU A 164
SER A 310
ILE A 230
ARG A 308
 None
 1.16A 4qi9B-5j0aA:
undetectable		 4qi9B-5j0aA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 GLY A 166
ILE A 184
ASN A 172
PHE A 231
LEU A 235
 None
 1.13A 5fa8A-5j0aA:
undetectable		 5fa8A-5j0aA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		3 / 3 ILE A 245
PRO A 246
ILE A 248
 None
 0.40A 5hw8F-5j0aA:
undetectable		 5hw8F-5j0aA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 10 GLY A  99
TYR A 100
SER A  91
LEU A  92
LEU A 163
 None
 1.27A 5hwkA-5j0aA:
undetectable		 5hwkA-5j0aA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens) 		5 / 10 GLY A  99
TYR A 100
SER A  91
LEU A  92
LEU A 163
 None
 1.27A 5hwkB-5j0aA:
undetectable		 5hwkB-5j0aA:
20.19