SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j0b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5j0b MYELOID CELL SURFACE
ANTIGEN CD33
(Homo
sapiens) 		3 / 3 ASP A 112
ARG A 111
ARG A 109
 None
 0.99A 2j9dA-5j0bA:
undetectable
2j9dC-5j0bA:
undetectable		 2j9dA-5j0bA:
18.02
2j9dC-5j0bA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5j0b MYELOID CELL SURFACE
ANTIGEN CD33
(Homo
sapiens) 		4 / 7 LEU A 210
TRP A 179
SER A 181
THR A 185
 None
 1.29A 3dzgB-5j0bA:
undetectable		 3dzgB-5j0bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5j0b MYELOID CELL SURFACE
ANTIGEN CD33
(Homo
sapiens) 		4 / 6 LEU A 210
TRP A 179
SER A 181
THR A 185
 None
 1.26A 3ropA-5j0bA:
undetectable		 3ropA-5j0bA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5j0b MYELOID CELL SURFACE
ANTIGEN CD33
(Homo
sapiens) 		4 / 6 ASP A 107
GLU A  85
VAL A  73
ALA A  74
 None
 0.98A 4nkxA-5j0bA:
undetectable		 4nkxA-5j0bA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5j0b MYELOID CELL SURFACE
ANTIGEN CD33
(Homo
sapiens) 		6 / 12 LEU A 134
SER A 115
ILE A 105
VAL A 138
VAL A  31
VAL A  37
 None
 1.45A 5dpdA-5j0bA:
undetectable		 5dpdA-5j0bA:
15.65