SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OND_A_ADNA506_2 (ADENOSYLHOMOCYSTEINA SE)	5j12	THYMIC STROMAL LYMPHOPOIETIN (Homo sapiens)	3 / 3	GLN A 117 THR A 116 LEU A 76	None	0.75A	3ondA-5j12A: undetectable	3ondA-5j12A: 15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OND_B_ADNB507_2 (ADENOSYLHOMOCYSTEINA SE)	5j12	THYMIC STROMAL LYMPHOPOIETIN (Homo sapiens)	3 / 3	GLN A 117 THR A 116 LEU A 76	None	0.73A	3ondB-5j12A: undetectable	3ondB-5j12A: 15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S79_A_ASDA601_1 (CYTOCHROME P450 19A1)	5j12	THYMIC STROMAL LYMPHOPOIETIN (Homo sapiens)	5 / 12	ILE A 47 TRP A 148 ILE A 39 ALA A 105 LEU A 93	None	1.13A	3s79A-5j12A: undetectable	3s79A-5j12A: 14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ECK_B_FOLB703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	5j12	CYTOKINE RECEPTOR-LIKE FACTOR 2 (Homo sapiens)	5 / 12	PHE C 58 SER C 98 LEU C 95 VAL C 44 THR C 81	None	1.04A	4eckB-5j12C: undetectable	4eckB-5j12C: 16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LHM_A_AZZA510_1 (THYMIDINE PHOSPHORYLASE)	5j12	CYTOKINE RECEPTOR-LIKE FACTOR 2 (Homo sapiens)	5 / 11	VAL C 170 ILE C 172 SER C 162 PHE C 127 LEU C 175	None	1.18A	4lhmA-5j12C: undetectable	4lhmA-5j12C: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JKV_A_ASDA602_1 (AROMATASE)	5j12	THYMIC STROMAL LYMPHOPOIETIN (Homo sapiens)	5 / 12	ILE A 47 TRP A 148 ILE A 39 ALA A 105 LEU A 93	None	1.12A	5jkvA-5j12A: undetectable	5jkvA-5j12A: 14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O4Y_A_CCSA14_0 (PHE-MAA-ASN-PRO-HIS- LEU-SER-TRP-SER-TRP- 9KK-9KK-ARG-CCS-GLY- NH2)	5j12	THYMIC STROMAL LYMPHOPOIETIN (Homo sapiens)	4 / 6	LEU A 144 TRP A 148 ARG A 150 GLY A 146	None	1.01A	5o4yA-5j12A: undetectable	5o4yA-5j12A: 6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O4Y_F_CCSF14_0 (PHE-MAA-ASN-PRO-HIS- LEU-SER-TRP-SER-TRP- 9KK-9KK-ARG-CCS-GLY- NH2)	5j12	THYMIC STROMAL LYMPHOPOIETIN (Homo sapiens)	4 / 6	LEU A 144 TRP A 148 ARG A 150 GLY A 146	None	1.11A	5o4yF-5j12A: undetectable	5o4yF-5j12A: 6.54

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3OND_A_ADNA506_2","ADENOSYLHOMOCYSTEINASE","5j12","THYMIC STROMAL LYMPHOPOIETIN","Homo sapiens",3,"GLN A 117;THR A 116;LEU A  76","None","0.75A","3ondA-5j12A:undetectable","3ondA-5j12A:15.78"],["3OND_B_ADNB507_2","ADENOSYLHOMOCYSTEINASE","5j12","THYMIC STROMAL LYMPHOPOIETIN","Homo sapiens",3,"GLN A 117;THR A 116;LEU A  76","None","0.73A","3ondB-5j12A:undetectable","3ondB-5j12A:15.78"],["3S79_A_ASDA601_1","CYTOCHROME P450 19A1","5j12","THYMIC STROMAL LYMPHOPOIETIN","Homo sapiens",5,"ILE A  47;TRP A 148;ILE A  39;ALA A 105;LEU A  93","None","1.13A","3s79A-5j12A:undetectable","3s79A-5j12A:14.48"],["4ECK_B_FOLB703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","5j12","CYTOKINE RECEPTOR-LIKE FACTOR 2","Homo sapiens",5,"PHE C  58;SER C  98;LEU C  95;VAL C  44;THR C  81","None","1.04A","4eckB-5j12C:undetectable","4eckB-5j12C:16.20"],["4LHM_A_AZZA510_1","THYMIDINE PHOSPHORYLASE","5j12","CYTOKINE RECEPTOR-LIKE FACTOR 2","Homo sapiens",5,"VAL C 170;ILE C 172;SER C 162;PHE C 127;LEU C 175","None","1.18A","4lhmA-5j12C:undetectable","4lhmA-5j12C:19.05"],["5JKV_A_ASDA602_1","AROMATASE","5j12","THYMIC STROMAL LYMPHOPOIETIN","Homo sapiens",5,"ILE A  47;TRP A 148;ILE A  39;ALA A 105;LEU A  93","None","1.12A","5jkvA-5j12A:undetectable","5jkvA-5j12A:14.48"],["5O4Y_A_CCSA14_0","PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2","5j12","THYMIC STROMAL LYMPHOPOIETIN","Homo sapiens",4,"LEU A 144;TRP A 148;ARG A 150;GLY A 146","None","1.01A","5o4yA-5j12A:undetectable","5o4yA-5j12A:6.54"],["5O4Y_F_CCSF14_0","PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2","5j12","THYMIC STROMAL LYMPHOPOIETIN","Homo sapiens",4,"LEU A 144;TRP A 148;ARG A 150;GLY A 146","None","1.11A","5o4yF-5j12A:undetectable","5o4yF-5j12A:6.54"]]