SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j13'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5j13 ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 VAL B 110
ARG B  63
ALA B  21
GLU B  85
 None
None
None
SO4  B 301 (-3.2A)
 0.99A 1dmiA-5j13B:
undetectable
1dmiB-5j13B:
undetectable		 1dmiA-5j13B:
19.27
1dmiB-5j13B:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5j13 ANTI-TSLP
FAB-FRAGMENT, HEAVY
CHAIN
ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		6 / 12 TYR B  38
GLN B  91
PHE B 102
VAL C  40
ALA C 100
TRP C 115
 None
 0.63A 1h8sA-5j13B:
18.0		 1h8sA-5j13B:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5j13 ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 GLY B  26
GLN B   9
VAL B  35
ALA B  73
 None
 0.83A 1p6kA-5j13B:
undetectable		 1p6kA-5j13B:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5j13 ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
ANTI-TSLP
FAB-FRAGMENT, HEAVY
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B  38
PRO B  46
TYR B  89
TYR C  98
 None
 0.72A 2oldA-5j13B:
26.8
2oldB-5j13B:
18.7		 2oldA-5j13B:
66.94
2oldB-5j13B:
66.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 5j13 ANTI-TSLP
FAB-FRAGMENT, HEAVY
CHAIN
ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 PHE C 178
VAL B 200
VAL B 149
PRO B 118
PHE B 144
 None
 1.44A 3nbrA-5j13C:
undetectable		 3nbrA-5j13C:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5j13 ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 THR B  76
TYR B  88
TRP B  37
ARG B  22
 None
 1.14A 3wipB-5j13B:
3.2
3wipC-5j13B:
3.1		 3wipB-5j13B:
22.18
3wipC-5j13B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5j13 ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 TRP B  37
ARG B  22
THR B  76
TYR B  88
 None
 1.24A 3wipA-5j13B:
undetectable
3wipE-5j13B:
undetectable		 3wipA-5j13B:
22.18
3wipE-5j13B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 5j13 ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 ASP B  53
LEU B  30
GLY B  31
 None
 0.52A 4xmfA-5j13B:
undetectable		 4xmfA-5j13B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5j13 ANTI-TSLP
FAB-FRAGMENT, HEAVY
CHAIN
ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 TYR B  89
GLY B 105
THR B 106
GLY C 186
 None
 0.85A 5jlcA-5j13B:
undetectable		 5jlcA-5j13B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5j13 ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 THR B  76
SER B  65
THR B  74
SER B  67
 None
 1.03A 5l4eA-5j13B:
2.2
5l4eB-5j13B:
2.3
5l4eC-5j13B:
2.3
5l4eD-5j13B:
2.3
5l4eE-5j13B:
2.3		 5l4eA-5j13B:
20.63
5l4eB-5j13B:
20.63
5l4eC-5j13B:
20.63
5l4eD-5j13B:
20.63
5l4eE-5j13B:
20.63