SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 12 GLY A 230
ALA A 180
VAL A 186
GLY A 234
ILE A 227
 None
 1.00A 1c6zB-5j1kA:
undetectable		 1c6zB-5j1kA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 10 GLY A 230
ALA A 180
VAL A 186
GLY A 234
ILE A 227
 None
 0.89A 1muiA-5j1kA:
undetectable		 1muiA-5j1kA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 10 GLY A 237
LEU A 174
SER A 146
TYR A 145
PHE A 170
 None
 1.25A 2h21A-5j1kA:
undetectable		 2h21A-5j1kA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 11 GLY A 237
LEU A 174
SER A 146
TYR A 145
PHE A 170
 None
 1.27A 2h21B-5j1kA:
undetectable		 2h21B-5j1kA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 11 GLY A 237
LEU A 174
SER A 146
TYR A 145
PHE A 170
 None
 1.28A 2h21C-5j1kA:
undetectable		 2h21C-5j1kA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 12 GLY A 230
ALA A 180
VAL A 186
GLY A 234
ILE A 227
 None
 1.00A 2z54A-5j1kA:
undetectable		 2z54A-5j1kA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 6 ASN A 138
SER A 181
ALA A 182
HIS A 205
 None
 1.23A 3aruA-5j1kA:
undetectable		 3aruA-5j1kA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 7 ILE A 142
LEU A 264
THR A 151
ARG A 252
 None
 1.28A 3nxuA-5j1kA:
undetectable		 3nxuA-5j1kA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		3 / 3 HIS A 218
SER A 239
ASN A 192
 None
 0.87A 3s8pB-5j1kA:
undetectable		 3s8pB-5j1kA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 4 LEU A 254
ILE A 281
GLY A 255
PHE A 209
 None
 1.05A 4dc3A-5j1kA:
undetectable		 4dc3A-5j1kA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		3 / 3 PRO A 157
TYR A 197
GLY A 240
 None
 0.67A 4g2zA-5j1kA:
undetectable		 4g2zA-5j1kA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 12 GLY A 230
ALA A 180
VAL A 186
GLY A 234
ILE A 227
 None
 1.05A 4njvD-5j1kA:
undetectable		 4njvD-5j1kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 4 ILE A 158
ARG A 252
TYR A 197
GLU A 250
 None
 1.30A 4zzbD-5j1kA:
undetectable		 4zzbD-5j1kA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		3 / 3 HIS A 218
SER A 239
ASN A 192
 None
 0.91A 5cprB-5j1kA:
undetectable		 5cprB-5j1kA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 5 ILE A 158
HIS A 215
HIS A 248
TYR A 197
 None
 1.39A 5ocsA-5j1kA:
undetectable		 5ocsA-5j1kA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 5j1k TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 5 ILE A 158
HIS A 215
HIS A 248
TYR A 197
 None
 1.39A 5ocsC-5j1kA:
undetectable		 5ocsC-5j1kA:
20.27