SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 12 GLY A 234
ALA A 184
VAL A 190
ILE A 205
GLY A 238
 None
 1.06A 1c6zA-5j1lA:
undetectable		 1c6zA-5j1lA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 10 GLY B 230
ALA B 180
VAL B 186
GLY B 234
ILE B 227
 None
 0.87A 1muiA-5j1lB:
undetectable		 1muiA-5j1lB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		3 / 3 ARG A 256
TYR A 216
LYS A 206
 None
 1.04A 1uujB-5j1lA:
undetectable		 1uujB-5j1lA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		3 / 3 HIS A 219
HIS A 250
HIS A 252
 ZN  A 401 (-4.4A)
ZN  A 401 (-4.1A)
ZN  A 401 (-4.0A)
 0.74A 1w2zA-5j1lA:
undetectable		 1w2zA-5j1lA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori;
Helicobacter
pylori) 		5 / 12 PHE B 207
VAL B 289
ASN A 141
PHE A 267
VAL A 255
 None
 1.17A 2ft9A-5j1lB:
undetectable		 2ft9A-5j1lB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 10 GLY B 237
LEU B 174
SER B 146
TYR B 145
PHE B 170
 None
 1.22A 2h21A-5j1lB:
undetectable		 2h21A-5j1lB:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 11 GLY B 237
LEU B 174
SER B 146
TYR B 145
PHE B 170
 None
 1.23A 2h21B-5j1lB:
undetectable		 2h21B-5j1lB:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 11 GLY B 237
LEU B 174
SER B 146
TYR B 145
PHE B 170
 None
 1.25A 2h21C-5j1lB:
undetectable		 2h21C-5j1lB:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 12 GLY B 230
ALA B 180
VAL B 186
GLY B 234
ILE B 227
 None
 1.01A 2qhcB-5j1lB:
undetectable		 2qhcB-5j1lB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 7 PHE A 208
THR A 227
ILE B 185
GLY B 255
 None
 0.97A 2v0mB-5j1lA:
undetectable		 2v0mB-5j1lA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 6 ASN A 141
SER A 185
ALA A 186
HIS A 209
 None
 1.23A 3aruA-5j1lA:
undetectable		 3aruA-5j1lA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 6 ASN B 138
SER B 181
ALA B 182
HIS B 205
 None
 1.16A 3aruA-5j1lB:
undetectable		 3aruA-5j1lB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 5 HIS A 250
HIS A 219
ASP A 173
HIS A 252
 ZN  A 401 (-4.1A)
ZN  A 401 (-4.4A)
ZN  A 401 (-2.6A)
ZN  A 401 (-4.0A)
 0.93A 3c0zA-5j1lA:
undetectable		 3c0zA-5j1lA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 6 HIS A 250
HIS A 219
ASP A 173
HIS A 252
 ZN  A 401 (-4.1A)
ZN  A 401 (-4.4A)
ZN  A 401 (-2.6A)
ZN  A 401 (-4.0A)
 0.94A 3c0zC-5j1lA:
undetectable		 3c0zC-5j1lA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 12 TYR A 253
HIS A 252
ASN A 168
ASN A 263
ARG A 256
 None
ZN  A 401 (-4.0A)
ZN  A 401 (-3.8A)
None
None
 1.36A 3cb8A-5j1lA:
undetectable		 3cb8A-5j1lA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 12 LEU B 135
ILE B 293
SER A 187
LEU A 138
LEU A 297
 None
 1.11A 3k2hA-5j1lB:
undetectable		 3k2hA-5j1lB:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 7 GLY A 191
PHE B 253
GLY B 208
PHE B 209
 None
 0.97A 3ko0M-5j1lA:
undetectable
3ko0P-5j1lA:
undetectable		 3ko0M-5j1lA:
20.19
3ko0P-5j1lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 10 GLY A 191
PHE B 263
PHE B 253
GLY B 208
PHE B 209
 None
 1.33A 3ko0R-5j1lA:
undetectable
3ko0T-5j1lA:
undetectable		 3ko0R-5j1lA:
20.19
3ko0T-5j1lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 12 LEU B 131
LEU B 135
SER A 187
VAL B 294
GLN B 128
 None
 1.19A 3m7rA-5j1lB:
undetectable		 3m7rA-5j1lB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 8 PHE A 208
VAL A 189
GLY A 228
GLY B 208
 None
 0.70A 3n9jB-5j1lA:
undetectable		 3n9jB-5j1lA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 7 ILE B 142
LEU B 264
THR B 151
ARG B 252
 None
 1.28A 3nxuA-5j1lB:
undetectable		 3nxuA-5j1lB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 10 ALA A 184
VAL A 190
ILE A 205
GLY A 238
VAL A 231
 None
 0.96A 3t3cB-5j1lA:
undetectable		 3t3cB-5j1lA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 12 ILE A 205
LEU A 220
ALA A 184
LEU A 251
GLY A 188
 None
 1.12A 3vaqB-5j1lA:
undetectable		 3vaqB-5j1lA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 4 LEU A 258
ILE A 285
GLY A 212
PHE B 226
 None
 0.95A 4dc3A-5j1lA:
undetectable		 4dc3A-5j1lA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 4 LEU B 254
ILE B 281
GLY B 208
PHE A 230
 None
 0.96A 4dc3A-5j1lB:
undetectable		 4dc3A-5j1lB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 4 LEU B 254
ILE B 281
GLY B 255
PHE B 209
 None
 1.05A 4dc3A-5j1lB:
undetectable		 4dc3A-5j1lB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		3 / 3 PRO B 157
TYR B 197
GLY B 240
 None
 0.71A 4g2zA-5j1lB:
undetectable		 4g2zA-5j1lB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 11 GLY A 202
GLY A 200
GLY A 199
ALA A 218
HIS A 219
 None
None
None
None
ZN  A 401 (-4.4A)
 1.12A 4l8fB-5j1lA:
undetectable		 4l8fB-5j1lA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		5 / 11 GLY A 202
GLY A 200
GLY A 199
ALA A 218
HIS A 219
 None
None
None
None
ZN  A 401 (-4.4A)
 1.13A 4l8fD-5j1lA:
undetectable		 4l8fD-5j1lA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 5 GLU A 229
THR A 227
HIS A 219
LEU A 220
 None
None
ZN  A 401 (-4.4A)
None
 1.26A 5axaA-5j1lA:
undetectable		 5axaA-5j1lA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 5 GLU A 146
THR A 268
HIS A 167
LEU A 174
 None
 1.28A 5axaC-5j1lA:
undetectable		 5axaC-5j1lA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 7 LEU A 174
GLU A 146
ILE A 205
VAL A 182
 None
 1.18A 5jh7C-5j1lA:
undetectable		 5jh7C-5j1lA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 5 ILE B 158
HIS B 215
HIS B 248
TYR B 197
 None
 1.41A 5ocsA-5j1lB:
undetectable		 5ocsA-5j1lB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 5j1l TOXR-ACTIVATED GENE
(TAGE)
(Helicobacter
pylori) 		4 / 5 ILE B 158
HIS B 215
HIS B 248
TYR B 197
 None
 1.41A 5ocsC-5j1lB:
undetectable		 5ocsC-5j1lB:
20.54