SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		3 / 3 LEU B 453
PHE B 280
ARG B 449
 None
 0.70A 1xdkF-5j1sB:
undetectable		 1xdkF-5j1sB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		5 / 12 PHE B 378
PHE B 389
ALA B 393
GLY B 354
GLY B 358
 None
 1.02A 2igtA-5j1sB:
undetectable		 2igtA-5j1sB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		5 / 12 PHE B 378
PHE B 389
ALA B 393
GLY B 354
GLY B 358
 None
 1.03A 2igtB-5j1sB:
undetectable		 2igtB-5j1sB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		4 / 6 LEU B 273
PHE B 298
LEU B 311
PHE B 266
 None
 1.02A 3abkP-5j1sB:
undetectable
3abkW-5j1sB:
undetectable		 3abkP-5j1sB:
21.99
3abkW-5j1sB:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		5 / 12 ALA B 300
HIS B 365
LEU B 311
ILE B 296
LEU B 273
 None
 1.05A 3nrrB-5j1sB:
undetectable		 3nrrB-5j1sB:
17.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		7 / 12 VAL C   3
ALA C  25
MET C  35
ARG C  72
ASN C  77
VAL C  79
ALA C  98
 None
 0.96A 3qxtA-5j1sC:
19.6		 3qxtA-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		8 / 12 VAL C   3
LEU C   5
ALA C  25
MET C  35
ARG C  72
VAL C  79
ALA C  98
TYR C 112
 None
 0.81A 3qxtB-5j1sC:
19.9		 3qxtB-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		7 / 12 ALA C  25
MET C  35
ARG C  72
ASN C  74
VAL C  79
ALA C  98
TYR C 112
 None
 0.86A 3qxvA-5j1sC:
19.3		 3qxvA-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		6 / 12 VAL C   3
ALA C  25
MET C  35
VAL C  79
ALA C  98
TYR C 112
 None
 0.71A 3qxvA-5j1sC:
19.3		 3qxvA-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		5 / 12 ALA C  25
MET C  35
ARG C  72
VAL C  79
ALA C  98
 None
 0.94A 3qxvB-5j1sC:
19.4		 3qxvB-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		6 / 12 VAL C   3
ALA C  25
MET C  35
VAL C  79
ALA C  98
TYR C 112
 None
 0.74A 3qxvB-5j1sC:
19.4		 3qxvB-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		6 / 11 ALA C  25
MET C  35
ARG C  72
ASN C  74
VAL C  79
ALA C  98
 None
 0.90A 3qxvC-5j1sC:
19.7		 3qxvC-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		5 / 11 VAL C   3
ALA C  25
MET C  35
VAL C  79
ALA C  98
 None
 0.72A 3qxvC-5j1sC:
19.7		 3qxvC-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		7 / 12 VAL C   3
ALA C  25
MET C  35
ARG C  72
VAL C  79
ALA C  98
TYR C 112
 None
 0.88A 3qxvD-5j1sC:
19.5		 3qxvD-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		6 / 12 ALA C  25
MET C  35
ARG C  72
VAL C  79
ALA C  98
TYR C 112
 None
 0.89A 3qxvE-5j1sC:
15.9		 3qxvE-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		5 / 12 CYH C  23
ALA C  25
VAL C  79
ALA C  98
TYR C 112
 None
 0.68A 3qxvE-5j1sC:
15.9		 3qxvE-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		5 / 12 CYH C  23
SER C  31
VAL C  79
ALA C  98
TYR C 112
 None
 1.27A 3qxvE-5j1sC:
15.9		 3qxvE-5j1sC:
66.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		5 / 10 TYR B 381
ASP B 348
PHE B 355
ILE B 330
PHE B 378
 None
 1.42A 3uqaA-5j1sB:
undetectable		 3uqaA-5j1sB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		5 / 10 TYR B 381
ASP B 348
PHE B 355
ILE B 330
PHE B 378
 None
 1.40A 4dz3A-5j1sB:
undetectable		 4dz3A-5j1sB:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		5 / 10 TYR B 381
ASP B 348
PHE B 355
ILE B 330
PHE B 378
 None
 1.45A 4laxA-5j1sB:
undetectable		 4laxA-5j1sB:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		4 / 6 THR B 397
LEU B 281
LEU B 262
GLU B 263
 None
 1.11A 4nc3A-5j1sB:
undetectable		 4nc3A-5j1sB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		5 / 10 TYR B 381
ASP B 348
PHE B 355
ILE B 330
PHE B 378
 None
 1.41A 4nnrB-5j1sB:
undetectable		 4nnrB-5j1sB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		3 / 3 PHE B 259
THR B 397
LEU B 273
 None
 0.65A 4qztA-5j1sB:
undetectable		 4qztA-5j1sB:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		4 / 5 ILE B 328
PHE B 280
SER B 326
ASP B 391
 None
 1.41A 4rzvB-5j1sB:
undetectable		 4rzvB-5j1sB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		5 / 11 TYR B 381
ASP B 348
PHE B 355
ILE B 330
PHE B 378
 None
 1.41A 5huaA-5j1sB:
undetectable		 5huaA-5j1sB:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2
(Homo
sapiens) 		5 / 10 ALA B 393
PHE B 378
ILE B 450
VAL B 364
ALA B 361
 None
 1.10A 5nukA-5j1sB:
undetectable		 5nukA-5j1sB:
15.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 5j1s VHH DOMAIN BS-2
(Vicugna
pacos) 		3 / 3 TYR C  60
GLY C  66
THR C  69
 None
 0.16A 6cjkB-5j1sC:
19.3		 6cjkB-5j1sC:
51.20