SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 5j1t TORSIN-1A
(Homo
sapiens) 		5 / 12 SER A 112
ASN A 118
VAL A  83
ALA A  82
VAL A 267
 None
 1.23A 2nniA-5j1tA:
undetectable		 2nniA-5j1tA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5j1t TORSIN-1A
(Homo
sapiens) 		4 / 8 ILE A 155
LEU A 131
PHE A 132
PHE A 138
 None
 0.89A 2vctA-5j1tA:
undetectable		 2vctA-5j1tA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5j1t TORSIN-1A
(Homo
sapiens) 		4 / 8 ILE A 155
LEU A 131
PHE A 132
PHE A 138
 None
 0.86A 2vctB-5j1tA:
undetectable		 2vctB-5j1tA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5j1t TORSIN-1A
(Homo
sapiens) 		4 / 7 ILE A 155
LEU A 131
PHE A 132
PHE A 138
 None
 0.89A 2vctD-5j1tA:
undetectable		 2vctD-5j1tA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 5j1t TORSIN-1A
(Homo
sapiens) 		3 / 3 PRO A  92
PHE A 203
LYS A  94
 None
 1.27A 3bjwG-5j1tA:
undetectable		 3bjwG-5j1tA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5j1t TORSIN-1A
(Homo
sapiens) 		4 / 8 SER A 243
VAL A 244
PHE A 245
HIS A 238
 None
 0.94A 3fhxB-5j1tA:
undetectable		 3fhxB-5j1tA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5j1t TORSIN-1A
(Homo
sapiens) 		5 / 10 ASP A 173
MET A 172
ASN A 109
SER A 112
ILE A 168
 None
None
MG  A 402 ( 2.9A)
None
None
 1.17A 3qg2A-5j1tA:
undetectable		 3qg2A-5j1tA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 5j1t TORSIN-1A
(Homo
sapiens) 		5 / 10 LEU A  98
ASP A 170
ILE A 168
ILE A 114
ILE A 204
 None
MG  A 402 ( 3.8A)
None
None
None
 0.95A 3s43B-5j1tA:
undetectable		 3s43B-5j1tA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5j1t TORSIN-1A
(Homo
sapiens) 		4 / 7 VAL A 297
SER A 298
ALA A 301
ARG A 282
 None
 0.82A 5fpdA-5j1tA:
2.4		 5fpdA-5j1tA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5j1t TORSIN-1A
(Homo
sapiens) 		4 / 4 ASN A  89
ILE A  79
TYR A 265
PHE A 203
 None
 1.35A 5igvA-5j1tA:
undetectable		 5igvA-5j1tA:
19.55