SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		4 / 8 GLY A 483
TRP A 431
TYR A 491
HIS A 488
 None
UNX  A 504 ( 4.3A)
None
None
 1.08A 1maaD-5j39A:
undetectable		 1maaD-5j39A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		4 / 8 GLY A 395
ASN A 394
TRP A 322
TYR A 387
 None
 1.14A 3ccfA-5j39A:
undetectable		 3ccfA-5j39A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		3 / 3 SER A 313
ASP A 393
ASN A 394
 None
CAC  A 501 (-3.6A)
None
 0.97A 3lsfB-5j39A:
undetectable
3lsfE-5j39A:
undetectable		 3lsfB-5j39A:
23.35
3lsfE-5j39A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 393
ASN A 394
SER A 313
 CAC  A 501 (-3.6A)
None
None
 0.85A 3lslA-5j39A:
undetectable
3lslD-5j39A:
undetectable		 3lslA-5j39A:
23.35
3lslD-5j39A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		3 / 3 SER A 313
ASP A 393
ASN A 394
 None
CAC  A 501 (-3.6A)
None
 0.84A 3lslA-5j39A:
undetectable
3lslD-5j39A:
undetectable		 3lslA-5j39A:
23.35
3lslD-5j39A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		4 / 5 LEU A 412
ARG A 329
ILE A 417
ARG A 301
 None
 1.35A 3ticA-5j39A:
undetectable		 3ticA-5j39A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		4 / 8 ASN A 319
PHE A 321
TRP A 466
TRP A 322
 UNX  A 504 ( 3.8A)
None
None
None
 1.37A 4v2zC-5j39A:
undetectable		 4v2zC-5j39A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 451
VAL A 312
GLU A 485
ALA A 492
GLY A 490
 UNX  A 503 ( 4.3A)
UNX  A 503 ( 4.0A)
None
None
None
 1.07A 5uxdB-5j39A:
undetectable		 5uxdB-5j39A:
22.59