SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		4 / 4 MET A 159
ALA A 169
TYR A 157
ILE A 170
 None
 1.32A 1upfD-5j3nA:
undetectable		 1upfD-5j3nA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		5 / 12 LEU A 363
LEU A 359
ALA A 352
ALA A 325
ILE A 398
 None
 1.10A 2h42C-5j3nA:
undetectable		 2h42C-5j3nA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		3 / 3 ASN A 176
LEU A 147
HIS A 175
 None
 0.84A 2q6fB-5j3nA:
undetectable		 2q6fB-5j3nA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 GLU A 320
PHE A 391
ALA A 352
PHE A 387
LEU A 328
 None
 1.39A 3a3yA-5j3nA:
undetectable		 3a3yA-5j3nA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		3 / 3 LYS A 374
ILE A 388
PHE A 391
 None
 1.00A 3j7zS-5j3nA:
undetectable
3j7za-5j3nA:
undetectable		 3j7zS-5j3nA:
15.21
3j7za-5j3nA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		4 / 6 ILE A 194
PHE A  89
ALA A  93
ASN A 191
 None
 1.13A 3pgyA-5j3nA:
undetectable
3pgyB-5j3nA:
undetectable		 3pgyA-5j3nA:
23.84
3pgyB-5j3nA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		5 / 9 PHE A  77
VAL A 118
ASN A 127
ILE A  20
PHE A  14
 None
GYS  A  72 ( 4.8A)
GYS  A  72 ( 3.8A)
None
None
 1.15A 3t3rB-5j3nA:
undetectable		 3t3rB-5j3nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		5 / 9 PHE A  77
VAL A 118
ASN A 127
ILE A  20
PHE A  14
 None
GYS  A  72 ( 4.8A)
GYS  A  72 ( 3.8A)
None
None
 1.18A 3t3rC-5j3nA:
undetectable		 3t3rC-5j3nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 PHE A  77
VAL A 118
ASN A 127
ILE A  20
PHE A  14
 None
GYS  A  72 ( 4.8A)
GYS  A  72 ( 3.8A)
None
None
 1.13A 3t3rD-5j3nA:
undetectable		 3t3rD-5j3nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		5 / 9 THR A 167
TYR A  98
LEU A 207
VAL A 230
VAL A 156
 None
 1.16A 3u9fP-5j3nA:
undetectable		 3u9fP-5j3nA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		4 / 7 ASP A  25
THR A 114
SER A  34
PHE A  33
 None
 1.04A 4ac9C-5j3nA:
undetectable		 4ac9C-5j3nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		3 / 3 HIS A  83
GLY A 234
ILE A 235
 None
 0.58A 4k50A-5j3nA:
undetectable		 4k50A-5j3nA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		3 / 3 HIS A  83
GLY A 234
ILE A 235
 None
 0.56A 4k50I-5j3nA:
undetectable		 4k50I-5j3nA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		4 / 6 VAL A  61
LEU A  59
LEU A 131
PHE A 171
 None
None
None
GYS  A  72 ( 4.5A)
 0.94A 4o1zA-5j3nA:
undetectable		 4o1zA-5j3nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		5 / 9 TYR A 342
ILE A 384
ILE A 343
VAL A 380
ILE A 329
 None
 1.28A 5mvnB-5j3nA:
1.2		 5mvnB-5j3nA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 TYR A 342
ILE A 384
ILE A 343
VAL A 380
ILE A 329
 None
 1.28A 5mvnD-5j3nA:
undetectable		 5mvnD-5j3nA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		5 / 12 ILE A 384
PHE A 391
SER A 386
GLN A 321
ILE A 329
 None
 1.12A 5n0sB-5j3nA:
undetectable		 5n0sB-5j3nA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		5 / 10 SER A  92
LEU A 207
SER A  78
ILE A 158
PRO A 202
 None
 1.48A 6dlzB-5j3nA:
3.0
6dlzC-5j3nA:
3.5		 6dlzB-5j3nA:
11.08
6dlzC-5j3nA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		5 / 10 SER A  92
LEU A 207
SER A  78
ILE A 158
PRO A 202
 None
 1.48A 6dm1B-5j3nA:
3.3
6dm1C-5j3nA:
3.6		 6dm1B-5j3nA:
11.08
6dm1C-5j3nA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		5 / 10 SER A  92
LEU A 207
SER A  78
ILE A 158
PRO A 202
 None
 1.47A 6dm2B-5j3nA:
3.2
6dm2C-5j3nA:
2.8		 6dm2B-5j3nA:
11.08
6dm2C-5j3nA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Escherichia
coli;
Aequorea
victoria) 		5 / 10 ILE A 158
PRO A 202
SER A  92
LEU A 207
SER A  78
 None
 1.48A 6dm2A-5j3nA:
2.8
6dm2D-5j3nA:
2.9		 6dm2A-5j3nA:
11.08
6dm2D-5j3nA:
11.08