SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j3p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		4 / 7 LEU A 161
TYR A 157
THR A 118
TRP A 119
 None
 1.39A 1afsA-5j3pA:
undetectable		 1afsA-5j3pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		4 / 7 LEU A 161
TYR A 157
THR A 118
TRP A 119
 None
 1.39A 1afsB-5j3pA:
undetectable		 1afsB-5j3pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		5 / 12 LEU A 337
ILE A 117
MET A 183
TYR A 168
TRP A 119
 None
 1.48A 1osvB-5j3pA:
undetectable		 1osvB-5j3pA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		4 / 5 LEU A 140
ILE A 117
LEU A 116
SER A 115
 None
 0.93A 2byoA-5j3pA:
undetectable		 2byoA-5j3pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		5 / 12 SER A 333
ASN A 357
GLY A 353
ILE A 121
THR A 296
 None
 1.43A 3a25A-5j3pA:
undetectable		 3a25A-5j3pA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		4 / 7 ASP A 350
ASP A 122
TYR A 178
ARG A 206
 MG  A 401 ( 4.3A)
MG  A 401 (-3.2A)
None
None
 1.27A 3s3oA-5j3pA:
undetectable		 3s3oA-5j3pA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		4 / 8 ASP A 262
SER A 229
HIS A 226
ASP A 316
 None
 1.11A 3sg9B-5j3pA:
undetectable		 3sg9B-5j3pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		5 / 11 ILE A 148
ALA A 141
LEU A 140
VAL A 136
LEU A 161
 None
 0.87A 4g1bB-5j3pA:
undetectable		 4g1bB-5j3pA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		4 / 5 PHE A 259
PHE A 319
LEU A 334
PRO A 290
 None
 1.39A 4o8zA-5j3pA:
undetectable		 4o8zA-5j3pA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		3 / 3 HIS A 226
ASP A 262
HIS A 351
 None
 0.78A 5oexB-5j3pA:
0.6		 5oexB-5j3pA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		3 / 3 HIS A 226
ASP A 262
HIS A 351
 None
 0.78A 5oexC-5j3pA:
0.7		 5oexC-5j3pA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		3 / 3 HIS A 226
ASP A 262
HIS A 351
 None
 0.77A 5oexD-5j3pA:
0.6		 5oexD-5j3pA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		5 / 12 LEU A 220
PHE A 114
ILE A 258
ALA A 260
ILE A 170
 None
 1.06A 5veuB-5j3pA:
undetectable		 5veuB-5j3pA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens) 		5 / 12 LEU A 354
GLY A 353
GLN A 151
VAL A 153
ILE A 121
 None
 1.46A 6bxnB-5j3pA:
undetectable		 6bxnB-5j3pA:
21.93