SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 210
ILE A 189
VAL A 244
TYR A 208
LEU A 111
 None
 0.91A 2japA-5j49A:
3.0		 2japA-5j49A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 210
ILE A 189
VAL A 244
TYR A 208
LEU A 111
 None
 0.93A 2japB-5j49A:
2.9		 2japB-5j49A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 210
ILE A 189
VAL A 244
TYR A 208
LEU A 111
 None
 0.90A 2japC-5j49A:
3.0		 2japC-5j49A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 210
ILE A 189
VAL A 244
TYR A 208
LEU A 111
 None
 0.90A 2japD-5j49A:
3.2		 2japD-5j49A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 203
TYR A 208
LEU A 111
ASP A 134
ASP A 255
 None
 1.43A 2vqyA-5j49A:
undetectable		 2vqyA-5j49A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		3 / 3 MET A 143
VAL A 157
GLU A 148
 None
 0.88A 3c6gA-5j49A:
undetectable		 3c6gA-5j49A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		5 / 9 GLY A 159
VAL A 160
ILE A 183
VAL A 149
GLN A 145
 None
 1.39A 3fi0N-5j49A:
undetectable		 3fi0N-5j49A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		4 / 6 LEU A 238
GLN A 243
LEU A 239
GLU A 242
 None
 0.73A 3h5gB-5j49A:
undetectable
3h5gC-5j49A:
undetectable		 3h5gB-5j49A:
8.85
3h5gC-5j49A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		4 / 6 LEU A 136
GLU A  44
PRO A 141
ARG A 207
 None
 1.47A 3ltwA-5j49A:
undetectable		 3ltwA-5j49A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		5 / 11 GLU A  44
TYR A 137
ALA A  41
ILE A  32
ALA A 265
 None
 1.17A 3nmuB-5j49A:
undetectable
3nmuJ-5j49A:
undetectable		 3nmuB-5j49A:
24.68
3nmuJ-5j49A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		4 / 5 ALA A  48
GLU A  44
ALA A 128
MET A  53
 None
 1.34A 3r9tC-5j49A:
undetectable		 3r9tC-5j49A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		4 / 8 ILE A 235
ILE A 158
VAL A 129
GLY A 206
 None
 0.81A 4acaC-5j49A:
undetectable		 4acaC-5j49A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		6 / 12 GLY A 112
LEU A 109
ILE A 214
LEU A 210
ILE A 235
GLY A 224
 None
 1.45A 5d4uC-5j49A:
undetectable		 5d4uC-5j49A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 136
LEU A 111
ILE A 235
ALA A 128
LEU A 210
 None
 1.30A 5ienA-5j49A:
undetectable		 5ienA-5j49A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		5 / 10 VAL A 160
GLY A 203
GLY A 172
ILE A 235
ALA A 246
 None
 0.88A 5vm8B-5j49A:
undetectable		 5vm8B-5j49A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		4 / 8 ILE A  50
PHE A 101
LEU A 121
ALA A 118
 None
 0.87A 5y7pC-5j49A:
undetectable		 5y7pC-5j49A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		4 / 5 PRO A 126
VAL A   4
GLY A 206
VAL A 157
 None
 0.95A 6ak3B-5j49A:
undetectable		 6ak3B-5j49A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		4 / 6 ASP A 134
TYR A 249
GLU A 161
GLU A 167
 None
 1.27A 6mn5A-5j49A:
undetectable		 6mn5A-5j49A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Paraburkholderia
xenovorans) 		4 / 6 ASP A 134
TYR A 249
GLU A 161
GLU A 167
 None
 1.25A 6mn5C-5j49A:
undetectable		 6mn5C-5j49A:
19.50