SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		3 / 3 MET A 269
LEU A 272
SER A 273
 None
 0.66A 1ee2A-5j4aA:
undetectable		 1ee2A-5j4aA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		4 / 7 LEU A 272
LEU A 265
ILE A 257
MET A 245
 None
 0.99A 1n13I-5j4aA:
undetectable
1n13L-5j4aA:
undetectable		 1n13I-5j4aA:
18.01
1n13L-5j4aA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5j4a IMMUNITY PROTEIN
CDII
(Burkholderia
pseudomallei) 		4 / 5 ILE B  66
LEU B  64
SER B  62
ARG B 103
 None
 0.98A 2byoA-5j4aB:
undetectable		 2byoA-5j4aB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		4 / 7 ILE A 257
MET A 245
LEU A 272
LEU A 265
 None
 1.02A 2qqcB-5j4aA:
undetectable
2qqcC-5j4aA:
undetectable		 2qqcB-5j4aA:
20.71
2qqcC-5j4aA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		4 / 7 LEU A 272
LEU A 265
ILE A 257
MET A 245
 None
 1.02A 2qqcA-5j4aA:
undetectable
2qqcF-5j4aA:
undetectable		 2qqcA-5j4aA:
18.01
2qqcF-5j4aA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		4 / 7 LEU A 272
LEU A 265
ILE A 257
MET A 245
 None
 1.02A 2qqcG-5j4aA:
undetectable
2qqcJ-5j4aA:
undetectable		 2qqcG-5j4aA:
18.01
2qqcJ-5j4aA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		4 / 7 LEU A 272
LEU A 265
ILE A 257
MET A 245
 None
 1.03A 2qqcI-5j4aA:
undetectable
2qqcL-5j4aA:
undetectable		 2qqcI-5j4aA:
18.01
2qqcL-5j4aA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5j4a IMMUNITY PROTEIN
CDII
(Burkholderia
pseudomallei) 		4 / 7 ILE B  54
LEU B  68
PHE B  67
PHE B  31
 None
 0.90A 2vctD-5j4aB:
undetectable		 2vctD-5j4aB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 5j4a IMMUNITY PROTEIN
CDII
(Burkholderia
pseudomallei) 		4 / 7 VAL B  42
LEU B  59
TYR B  43
ILE B  27
 None
 0.99A 3avpA-5j4aB:
undetectable		 3avpA-5j4aB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		5 / 12 LEU A 284
PHE A 268
PRO A 248
GLN A 253
ASP A 262
 None
 1.45A 4j7xA-5j4aA:
undetectable		 4j7xA-5j4aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		5 / 12 LEU A 284
PHE A 268
PRO A 248
GLN A 253
ASP A 262
 None
 1.43A 4j7xF-5j4aA:
undetectable		 4j7xF-5j4aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		5 / 12 LEU A 284
PHE A 268
PRO A 248
GLN A 253
ASP A 262
 None
 1.44A 4j7xJ-5j4aA:
undetectable		 4j7xJ-5j4aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5j4a IMMUNITY PROTEIN
CDII
(Burkholderia
pseudomallei) 		4 / 8 VAL B  42
TYR B  43
LEU B  94
LEU B  98
 None
 1.05A 4jtrA-5j4aB:
undetectable		 4jtrA-5j4aB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5j4a IMMUNITY PROTEIN
CDII
(Burkholderia
pseudomallei) 		5 / 12 ALA B   2
THR B  56
VAL B  42
LEU B  94
LEU B  23
 None
 1.05A 4qzuC-5j4aB:
undetectable		 4qzuC-5j4aB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		4 / 5 SER A 273
ALA A 276
MET A 245
LEU A 304
 None
 1.44A 5dzkb-5j4aA:
undetectable
5dzkp-5j4aA:
undetectable		 5dzkb-5j4aA:
21.88
5dzkp-5j4aA:
1.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5j4a IMMUNITY PROTEIN
CDII
(Burkholderia
pseudomallei) 		4 / 7 VAL B  42
THR B  56
VAL B  71
THR B  70
 None
 1.02A 5e4dA-5j4aB:
undetectable
5e4dB-5j4aB:
undetectable		 5e4dA-5j4aB:
20.00
5e4dB-5j4aB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5j4a IMMUNITY PROTEIN
CDII
(Burkholderia
pseudomallei) 		4 / 7 VAL B  71
THR B  70
VAL B  42
THR B  56
 None
 1.00A 5e4dA-5j4aB:
undetectable
5e4dB-5j4aB:
undetectable		 5e4dA-5j4aB:
20.00
5e4dB-5j4aB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		3 / 3 ALA A 300
ASN A 303
LEU A 304
 None
 0.30A 5i1nB-5j4aA:
undetectable		 5i1nB-5j4aA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		3 / 3 ALA A 300
ASN A 303
LEU A 304
 None
 0.16A 5i1oC-5j4aA:
undetectable		 5i1oC-5j4aA:
28.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5j4a TRNA NUCLEASE CDIA
(Burkholderia
pseudomallei) 		3 / 3 ALA A 300
ASN A 303
LEU A 304
 None
 0.16A 5i1pA-5j4aA:
undetectable		 5i1pA-5j4aA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 5j4a TRNA NUCLEASE CDIA
IMMUNITY PROTEIN
CDII
(Burkholderia
pseudomallei;
Burkholderia
pseudomallei) 		5 / 12 SER B  52
THR A 247
GLU A 204
GLY B   3
VAL B  15
 None
 1.17A 5jo9A-5j4aB:
undetectable		 5jo9A-5j4aB:
17.95