SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 10 LEU A 178
LEU A 182
PHE A 100
THR A 146
ILE A 138
 None
 1.36A 1i18A-5j4rA:
undetectable
1i18B-5j4rA:
undetectable		 1i18A-5j4rA:
16.67
1i18B-5j4rA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 10 PHE A 100
THR A 146
ILE A 138
LEU A 178
LEU A 182
 None
 1.35A 1i18A-5j4rA:
undetectable
1i18B-5j4rA:
undetectable		 1i18A-5j4rA:
16.67
1i18B-5j4rA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 12 LEU A 182
SER A 103
LEU A 178
THR A 180
GLY A 144
 None
 1.23A 1jffB-5j4rA:
undetectable		 1jffB-5j4rA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		4 / 7 TYR A 224
MET A 225
ASP A 226
ASP A 227
 None
 1.38A 1t03A-5j4rA:
undetectable		 1t03A-5j4rA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		3 / 3 PRO A 246
THR A 195
PRO A 197
 None
 0.87A 2d55C-5j4rA:
undetectable		 2d55C-5j4rA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 12 LEU A 182
SER A 103
LEU A 178
THR A 180
GLY A 144
 None
 1.23A 2hxfB-5j4rA:
undetectable		 2hxfB-5j4rA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 12 LEU A 182
SER A 103
LEU A 178
THR A 180
GLY A 144
 None
 1.23A 2hxhB-5j4rA:
undetectable		 2hxhB-5j4rA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		4 / 6 ASN A  18
GLN A 123
ILE A 192
PHE A 191
 None
None
None
AKG  A 301 (-4.1A)
 1.17A 2jn3A-5j4rA:
undetectable		 2jn3A-5j4rA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 12 LEU A 182
SER A 103
LEU A 178
THR A 180
GLY A 144
 None
 1.22A 2p4nB-5j4rA:
undetectable		 2p4nB-5j4rA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		4 / 8 ILE A  32
LEU A 251
PHE A 252
GLY A 254
 None
None
AKG  A 301 (-4.8A)
None
 0.91A 2vdbA-5j4rA:
undetectable		 2vdbA-5j4rA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		4 / 7 PRO A 142
PRO A 139
LEU A  96
PHE A 100
 None
 0.98A 2vl2B-5j4rA:
undetectable		 2vl2B-5j4rA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 12 LEU A 182
SER A 103
LEU A 178
THR A 180
GLY A 144
 None
 1.23A 2wbeB-5j4rA:
undetectable		 2wbeB-5j4rA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 12 LEU A 182
SER A 103
LEU A 178
THR A 180
GLY A 144
 None
 1.23A 3dcoB-5j4rA:
undetectable		 3dcoB-5j4rA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		4 / 6 ARG A 260
ILE A 161
VAL A 163
HIS A 259
 None
None
None
NI  A 302 ( 3.3A)
 1.42A 3deuA-5j4rA:
undetectable		 3deuA-5j4rA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB302_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		4 / 5 ARG A 260
ILE A 161
VAL A 163
HIS A 259
 None
None
None
NI  A 302 ( 3.3A)
 1.40A 3deuB-5j4rA:
undetectable		 3deuB-5j4rA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 12 LEU A 182
SER A 103
LEU A 178
THR A 180
GLY A 144
 None
 1.23A 3edlB-5j4rA:
undetectable		 3edlB-5j4rA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 12 LEU A 182
SER A 103
LEU A 178
THR A 180
GLY A 144
 None
 1.22A 3iz0B-5j4rA:
undetectable		 3iz0B-5j4rA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		3 / 3 PHE A 252
TYR A 206
LEU A  15
 AKG  A 301 (-4.8A)
None
None
 0.76A 3keeB-5j4rA:
undetectable		 3keeB-5j4rA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 10 ILE A 127
PHE A 279
SER A 185
LEU A 188
ALA A 278
 None
 1.35A 3lw5B-5j4rA:
undetectable		 3lw5B-5j4rA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		4 / 6 GLU A 202
PRO A 269
ARG A 270
GLY A 200
 None
None
AKG  A 301 (-2.6A)
None
 1.46A 3oxvA-5j4rA:
undetectable		 3oxvA-5j4rA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 12 THR A 151
ILE A  84
LEU A  59
VAL A  55
TYR A  99
 None
 1.10A 3sp9A-5j4rA:
undetectable		 3sp9A-5j4rA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 12 THR A 151
ILE A  84
LEU A  59
VAL A  55
TYR A  99
 None
 1.11A 3sp9B-5j4rA:
undetectable		 3sp9B-5j4rA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		3 / 3 PHE A 252
TYR A 206
LEU A  15
 AKG  A 301 (-4.8A)
None
None
 0.68A 3sueB-5j4rA:
undetectable		 3sueB-5j4rA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 9 PHE A  47
VAL A 124
PHE A 106
ILE A 273
GLY A 274
 None
 1.26A 3t3rC-5j4rA:
undetectable		 3t3rC-5j4rA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 10 PHE A  47
VAL A 124
PHE A 106
ILE A 273
GLY A 274
 None
 1.25A 3t3rD-5j4rA:
undetectable		 3t3rD-5j4rA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5j4r WELO5
(Hapalosiphon
welwitschii) 		4 / 6 GLY A 275
PHE A 120
ILE A 192
PHE A 114
 None
 0.88A 4qogA-5j4rA:
undetectable
4qogB-5j4rA:
undetectable		 4qogA-5j4rA:
18.86
4qogB-5j4rA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 12 PHE A 128
ILE A  29
VAL A  22
GLY A  40
MET A 249
 None
 1.20A 5byjA-5j4rA:
undetectable		 5byjA-5j4rA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TRQ_B_ACTB306_0
(WELO5)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		3 / 3 GLU A 209
ARG A 256
TYR A 257
 None
 0.25A 5trqB-5j4rA:
44.1		 5trqB-5j4rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TRQ_B_ACTB307_0
(WELO5)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		3 / 3 GLU A 125
HIS A 129
VAL A 136
 None
 0.08A 5trqB-5j4rA:
44.1		 5trqB-5j4rA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 10 PHE A 120
ILE A 192
PHE A  47
PHE A 106
ILE A 152
 None
 1.11A 6ebpC-5j4rA:
undetectable		 6ebpC-5j4rA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 11 PHE A 120
ILE A 192
PHE A  47
PHE A 106
ILE A 152
 None
 1.08A 6gp2A-5j4rA:
undetectable		 6gp2A-5j4rA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5j4r WELO5
(Hapalosiphon
welwitschii) 		5 / 11 PHE A 120
ILE A 192
PHE A  47
PHE A 106
ILE A 152
 None
 0.99A 6gp2B-5j4rA:
undetectable		 6gp2B-5j4rA:
18.14