SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5j57 VHH SINGLE CHAIN
ANTIBODY V5E1
(Vicugna
pacos) 		4 / 7 ALA B  49
TYR B  60
SER B  52
ALA B  34
 None
 1.02A 1k5qA-5j57B:
undetectable
1k5qB-5j57B:
undetectable		 1k5qA-5j57B:
17.54
1k5qB-5j57B:
14.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j57 VHH SINGLE CHAIN
ANTIBODY V5E1
(Vicugna
pacos) 		5 / 12 ALA B  24
ARG B  72
ASN B  74
VAL B  79
ALA B  98
 None
 0.44A 3qxvA-5j57B:
20.5		 3qxvA-5j57B:
65.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5j57 VHH SINGLE CHAIN
ANTIBODY V5E1
(Vicugna
pacos) 		5 / 11 ALA B  24
ARG B  72
ASN B  74
VAL B  79
ALA B  98
 None
 0.44A 3qxvC-5j57B:
20.9		 3qxvC-5j57B:
65.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 5j57 VHH SINGLE CHAIN
ANTIBODY V5E1
(Vicugna
pacos) 		5 / 12 GLY B 114
VAL B 115
TYR B  32
LEU B  29
ILE B  70
 None
 1.05A 4pd4C-5j57B:
undetectable		 4pd4C-5j57B:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5j57 VHH SINGLE CHAIN
ANTIBODY V5E1
(Vicugna
pacos) 		5 / 9 ALA B  34
THR B  33
ALA B  98
GLY B  55
GLY B  54
 None
 0.91A 4qwuY-5j57B:
undetectable
4qwuZ-5j57B:
undetectable		 4qwuY-5j57B:
23.26
4qwuZ-5j57B:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5j57 VHH SINGLE CHAIN
ANTIBODY V5E1
(Vicugna
pacos) 		4 / 4 VAL B 115
GLY B 114
ARG B 116
VAL B   2
 None
 1.38A 5d4nA-5j57B:
undetectable
5d4nB-5j57B:
undetectable		 5d4nA-5j57B:
22.05
5d4nB-5j57B:
22.05