SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		5 / 10 ASP A 213
SER A 121
ALA A 122
THR A 175
ASP A 216
 CA  A 626 (-3.2A)
None
None
None
CA  A 626 ( 2.9A)
 1.38A 1m4dA-5j5jA:
undetectable		 1m4dA-5j5jA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		5 / 9 ASP A 213
SER A 121
ALA A 122
THR A 175
ASP A 216
 CA  A 626 (-3.2A)
None
None
None
CA  A 626 ( 2.9A)
 1.34A 1m4dB-5j5jA:
undetectable		 1m4dB-5j5jA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		3 / 3 GLY A 193
GLU A 196
ASN A 142
 None
 0.73A 1zq9A-5j5jA:
undetectable		 1zq9A-5j5jA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		4 / 6 THR A 501
ASP A 468
ASN A 444
ASP A 443
 None
CA  A 632 (-2.1A)
CA  A 631 ( 4.5A)
CA  A 631 ( 2.7A)
 1.26A 2okcA-5j5jA:
undetectable		 2okcA-5j5jA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		5 / 12 VAL A 341
SER A 343
THR A 433
ILE A 396
ASN A 437
 MAN  A 611 ( 4.4A)
None
MAN  A 611 (-2.1A)
None
None
 1.15A 3ddyA-5j5jA:
undetectable		 3ddyA-5j5jA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		5 / 12 ILE A 130
ALA A 205
GLN A 206
ILE A 209
LEU A 162
 None
 1.06A 3dzuA-5j5jA:
undetectable		 3dzuA-5j5jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		3 / 3 SER A 146
ASP A 165
ASP A 192
 None
None
CA  A 624 (-3.6A)
 0.85A 3iv6A-5j5jA:
undetectable		 3iv6A-5j5jA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		4 / 6 GLN A  70
TYR A  71
PHE A  74
LEU A  50
 None
 1.39A 3tgvD-5j5jA:
undetectable		 3tgvD-5j5jA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		4 / 4 ASP A 248
ASP A 246
GLY A 251
THR A 274
 CA  A 626 ( 3.7A)
CA  A 627 (-2.2A)
None
None
 1.29A 3tl9B-5j5jA:
undetectable		 3tl9B-5j5jA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		5 / 12 SER A 146
GLN A 110
PHE A 113
ILE A 130
PHE A 108
 None
 1.18A 4c49A-5j5jA:
undetectable		 4c49A-5j5jA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		5 / 12 SER A 146
GLN A 110
PHE A 113
ILE A 130
PHE A 108
 None
 1.35A 4c49C-5j5jA:
undetectable		 4c49C-5j5jA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		4 / 7 GLU A  89
TYR A  86
ALA A  29
TYR A  32
 None
 1.10A 4zz8A-5j5jA:
undetectable		 4zz8A-5j5jA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		4 / 5 ARG A 241
GLY A 281
THR A 278
GLU A 280
 None
 1.19A 5btiA-5j5jA:
undetectable
5btiB-5j5jA:
undetectable		 5btiA-5j5jA:
22.31
5btiB-5j5jA:
18.60