SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		4 / 7 GLN A 392
THR A 431
TYR A 432
GLN A 362
 None
 1.37A 1eiiA-5j5uA:
undetectable		 1eiiA-5j5uA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 12 ASN A 435
TRP A 429
GLY A  65
SER A  81
THR A  77
 None
 1.23A 1g60A-5j5uA:
undetectable		 1g60A-5j5uA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 12 LEU A 393
TYR A 396
TYR A 345
LEU A 289
LEU A 285
 None
 1.15A 1p33C-5j5uA:
undetectable		 1p33C-5j5uA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		3 / 3 TYR A  70
ARG A 296
GLN A 392
 None
 1.01A 1tw4A-5j5uA:
undetectable		 1tw4A-5j5uA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 9 LEU A 428
VAL A 386
GLY A 385
LEU A 364
TYR A 432
 None
 1.44A 1vrtA-5j5uA:
undetectable		 1vrtA-5j5uA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		4 / 6 TRP A 443
TYR A 440
GLY A 463
SER A 459
 None
 1.38A 2a3cB-5j5uA:
undetectable		 2a3cB-5j5uA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		3 / 3 ASN A 120
ILE A 108
MET A 128
 None
 0.80A 2h42C-5j5uA:
undetectable		 2h42C-5j5uA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R6V_A_NCAA174_0
(UNCHARACTERIZED
PROTEIN PH0856)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		4 / 6 TYR A  54
HIS A 355
ASP A  51
HIS A 249
 None
 1.41A 2r6vA-5j5uA:
undetectable		 2r6vA-5j5uA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		4 / 8 ILE A 342
TYR A 396
LEU A 268
LEU A  60
 None
 0.89A 2w98B-5j5uA:
undetectable		 2w98B-5j5uA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		3 / 3 LEU A  60
TRP A  74
TYR A  62
 None
 0.96A 3aicA-5j5uA:
undetectable		 3aicA-5j5uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		3 / 3 LEU A  60
TRP A  74
TYR A  62
 None
 0.93A 3aicB-5j5uA:
undetectable		 3aicB-5j5uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		3 / 3 LEU A  60
TRP A  74
TYR A  62
 None
 0.96A 3aicE-5j5uA:
undetectable		 3aicE-5j5uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		3 / 3 LEU A  60
TRP A  74
TYR A  62
 None
 0.97A 3aicG-5j5uA:
undetectable		 3aicG-5j5uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		3 / 3 LEU A  60
TRP A  74
TYR A  62
 None
 0.95A 3aicH-5j5uA:
undetectable		 3aicH-5j5uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		3 / 3 TYR A  54
TYR A 140
ILE A 139
 None
 0.82A 3eteA-5j5uA:
undetectable
3eteB-5j5uA:
undetectable		 3eteA-5j5uA:
22.08
3eteB-5j5uA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 9 HIS A 248
LEU A 246
PRO A 352
LEU A 354
LEU A 393
 None
 1.18A 3q1eB-5j5uA:
undetectable
3q1eD-5j5uA:
undetectable		 3q1eB-5j5uA:
14.63
3q1eD-5j5uA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		4 / 8 TYR A 471
THR A 137
TYR A 161
TRP A  94
 None
 1.43A 3wipD-5j5uA:
undetectable
3wipE-5j5uA:
undetectable		 3wipD-5j5uA:
17.32
3wipE-5j5uA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		4 / 7 TYR A  54
HIS A 355
ASP A  51
HIS A 249
 None
 1.39A 3zodA-5j5uA:
undetectable		 3zodA-5j5uA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 12 SER A 359
PHE A 238
ARG A 135
THR A 431
GLN A 392
 None
 1.23A 4abzA-5j5uA:
undetectable		 4abzA-5j5uA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 7 GLY A 376
TYR A 370
ALA A 379
SER A 377
GLU A 420
 None
 1.27A 4hyfA-5j5uA:
undetectable		 4hyfA-5j5uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 8 GLY A 376
TYR A 370
ALA A 379
SER A 377
GLU A 420
 None
 1.30A 4hyfB-5j5uA:
undetectable		 4hyfB-5j5uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 8 GLY A 376
TYR A 370
ALA A 379
SER A 377
GLU A 420
 None
 1.29A 4hyfC-5j5uA:
undetectable		 4hyfC-5j5uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		4 / 7 GLN A 362
LEU A 428
THR A 431
THR A 419
 None
 1.06A 4mbsA-5j5uA:
undetectable		 4mbsA-5j5uA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		4 / 5 TYR A 448
LEU A 415
GLU A 367
VAL A 374
 None
 1.33A 4nkvA-5j5uA:
undetectable		 4nkvA-5j5uA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 11 SER A 441
LEU A 102
VAL A  97
TRP A 502
ILE A 167
 None
 1.30A 4pghC-5j5uA:
undetectable		 4pghC-5j5uA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 11 GLY A 376
TYR A 370
ALA A 379
SER A 377
GLU A 420
 None
 1.26A 4rv6A-5j5uA:
undetectable		 4rv6A-5j5uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 11 GLY A 376
TYR A 370
ALA A 379
SER A 377
GLU A 420
 None
 1.26A 4rv6B-5j5uA:
undetectable		 4rv6B-5j5uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 12 GLY A 463
LEU A 284
ILE A 430
GLY A 425
THR A 446
 None
 1.08A 4ze2A-5j5uA:
undetectable		 4ze2A-5j5uA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 11 GLN A 164
SER A 441
GLU A 438
PRO A 466
LEU A 469
 None
 1.42A 5jh7B-5j5uA:
1.4		 5jh7B-5j5uA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		3 / 3 TYR A 288
TYR A 382
GLN A 427
 None
 1.06A 5jsdA-5j5uA:
undetectable
5jsdB-5j5uA:
undetectable		 5jsdA-5j5uA:
21.98
5jsdB-5j5uA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		3 / 3 TYR A 288
TYR A 382
GLN A 427
 None
 1.05A 5jsdB-5j5uA:
undetectable
5jsdC-5j5uA:
undetectable		 5jsdB-5j5uA:
21.98
5jsdC-5j5uA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		5 / 12 ILE A 406
GLY A 389
THR A 431
LEU A 363
PHE A 381
 None
 1.39A 5v5zA-5j5uA:
undetectable		 5v5zA-5j5uA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 5j5u RAGB/SUSD DOMAIN
PROTEIN
(Flavobacterium
johnsoniae) 		3 / 3 ASP A 174
ASP A 162
ASN A 479
 None
 0.59A 6gngB-5j5uA:
undetectable		 6gngB-5j5uA:
22.99