SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 12 GLY A 113
ALA A 114
GLY A 258
GLY A 259
VAL A 260
 FAD  A 401 (-3.5A)
None
None
None
None
 0.87A 2avsA-5j60A:
undetectable		 2avsA-5j60A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 11 TYR A 237
VAL A 171
ALA A 168
LEU A 164
SER A 133
 None
 1.25A 2bxgA-5j60A:
undetectable		 2bxgA-5j60A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		4 / 7 MET A 254
LEU A  87
VAL A 273
MET A 266
 None
None
None
PG4  A 403 ( 3.8A)
 1.09A 2hrcA-5j60A:
undetectable		 2hrcA-5j60A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 12 LEU A 108
ASP A   5
VAL A  32
GLY A 101
VAL A  11
 None
None
None
None
FAD  A 401 ( 4.6A)
 0.96A 2ieoA-5j60A:
undetectable		 2ieoA-5j60A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		4 / 7 GLY A  14
ALA A 290
VAL A 109
ILE A  33
 FAD  A 401 (-3.3A)
FAD  A 401 (-3.4A)
None
None
 0.65A 3a2qA-5j60A:
undetectable		 3a2qA-5j60A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 12 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.08A 3eeyA-5j60A:
2.8		 3eeyA-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 12 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.07A 3eeyB-5j60A:
2.8		 3eeyB-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 12 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.08A 3eeyC-5j60A:
2.4		 3eeyC-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 12 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.13A 3eeyD-5j60A:
2.9		 3eeyD-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 12 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.00A 3eeyE-5j60A:
2.7		 3eeyE-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 12 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.01A 3eeyF-5j60A:
undetectable		 3eeyF-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 12 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.17A 3eeyI-5j60A:
3.3		 3eeyI-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 12 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.07A 3eeyJ-5j60A:
2.9		 3eeyJ-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		4 / 8 GLY A 184
ALA A 186
THR A 175
PRO A 176
 None
 0.64A 3el0A-5j60A:
undetectable		 3el0A-5j60A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 10 LEU A 108
ASP A   5
VAL A  32
GLY A 101
VAL A  11
 None
None
None
None
FAD  A 401 ( 4.6A)
 0.94A 3oxwA-5j60A:
undetectable		 3oxwA-5j60A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		4 / 5 PHE A 247
GLY A 275
THR A 268
VAL A 252
 FAD  A 401 ( 4.3A)
None
None
None
 0.71A 3wrkD-5j60A:
undetectable		 3wrkD-5j60A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		4 / 4 TRP A 274
LEU A 305
LEU A  29
THR A  24
 None
 1.49A 4bboD-5j60A:
undetectable		 4bboD-5j60A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		4 / 5 ILE A 206
ILE A 174
HIS A 172
VAL A 149
 None
 0.96A 5jmnA-5j60A:
undetectable		 5jmnA-5j60A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGG_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 5j60 THIOREDOXIN
REDUCTASE
(Gloeobacter
violaceus) 		5 / 12 PHE A 247
THR A 112
THR A 268
VAL A 270
GLN A 251
 FAD  A 401 ( 4.3A)
FAD  A 401 (-4.0A)
None
None
None
 1.37A 5wggA-5j60A:
1.6		 5wggA-5j60A:
22.06