SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 10 ALA A 121
PHE A  41
LEU A 114
ALA A  43
ILE A 118
 None
 1.22A 1g5yC-5j62A:
undetectable		 1g5yC-5j62A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 12 ILE A 191
LEU A  37
LEU A 114
ILE A  98
THR A  94
 None
 1.01A 1rb2B-5j62A:
undetectable		 1rb2B-5j62A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 12 ALA A  40
LEU A 114
ILE A 131
GLY A 190
LEU A  96
 None
None
FMN  A 301 (-3.7A)
None
None
 1.15A 2yjaB-5j62A:
undetectable		 2yjaB-5j62A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		4 / 7 LEU A  62
VAL A  57
THR A  55
VAL A 187
 None
 1.03A 2zaxA-5j62A:
undetectable		 2zaxA-5j62A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 12 THR A  94
GLY A 194
ILE A 191
GLY A 190
LEU A 127
 None
 1.13A 3eeyF-5j62A:
2.1		 3eeyF-5j62A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		4 / 7 LEU A  62
VAL A  57
THR A  55
VAL A 187
 None
 1.07A 3fwgB-5j62A:
undetectable		 3fwgB-5j62A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 12 GLY A 194
ALA A 124
ALA A 121
THR A  35
LEU A  36
 None
 1.06A 3p2kA-5j62A:
undetectable		 3p2kA-5j62A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 12 VAL A  56
LEU A 179
ILE A 118
ILE A  98
VAL A 187
 None
 0.88A 3w67D-5j62A:
undetectable		 3w67D-5j62A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 12 VAL A  56
LEU A 179
ILE A 118
ILE A  98
VAL A 187
 None
 0.87A 3w68C-5j62A:
undetectable		 3w68C-5j62A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 12 VAL A  56
LEU A 179
ILE A 118
ILE A  98
VAL A 187
 None
 0.89A 3w68D-5j62A:
undetectable		 3w68D-5j62A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 9 ILE A 131
GLY A 190
PHE A 189
THR A 115
GLY A 112
 FMN  A 301 (-3.7A)
None
FMN  A 301 ( 4.8A)
None
None
 0.94A 4acaB-5j62A:
undetectable
4acaC-5j62A:
undetectable		 4acaB-5j62A:
19.71
4acaC-5j62A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 9 ILE A 191
GLY A 190
PHE A 189
THR A 115
ARG A 204
 None
None
FMN  A 301 ( 4.8A)
None
FMN  A 301 (-3.8A)
 1.38A 4acaB-5j62A:
undetectable
4acaC-5j62A:
undetectable		 4acaB-5j62A:
19.71
4acaC-5j62A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 9 ILE A 191
GLY A 190
PHE A 189
THR A 115
GLY A 112
 None
None
FMN  A 301 ( 4.8A)
None
None
 1.32A 4acaB-5j62A:
undetectable
4acaC-5j62A:
undetectable		 4acaB-5j62A:
19.71
4acaC-5j62A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 11 ALA A  40
LEU A 114
ILE A 131
GLY A 190
LEU A  96
 None
None
FMN  A 301 (-3.7A)
None
None
 1.17A 4pxmB-5j62A:
undetectable		 4pxmB-5j62A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		4 / 6 LEU A 114
SER A  99
PRO A 188
PHE A  97
 None
 1.12A 5b8iA-5j62A:
undetectable		 5b8iA-5j62A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		4 / 5 TYR A 185
PHE A 189
LEU A 114
PRO A 188
 None
FMN  A 301 ( 4.8A)
None
None
 1.39A 5csyB-5j62A:
undetectable		 5csyB-5j62A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5j62 PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 11 ALA A  40
LEU A 114
ILE A 131
GLY A 190
LEU A  96
 None
None
FMN  A 301 (-3.7A)
None
None
 1.16A 5dxbB-5j62A:
undetectable		 5dxbB-5j62A:
19.35