SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 7 GLN A 773
TYR A 813
PHE A 723
PHE A 756
 None
 1.04A 1e71M-5j68A:
undetectable		 1e71M-5j68A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 7 GLN A 773
TYR A 813
PHE A 723
PHE A 756
 None
 1.02A 1e72M-5j68A:
undetectable		 1e72M-5j68A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 8 TYR A1260
GLY A1125
ARG A1124
LEU A1008
 None
 1.06A 1gsfA-5j68A:
undetectable		 1gsfA-5j68A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 8 TYR A1260
GLY A1125
ARG A1124
LEU A1008
 None
 1.06A 1gsfB-5j68A:
2.4		 1gsfB-5j68A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 8 TYR A1260
GLY A1125
ARG A1124
LEU A1008
 None
 1.06A 1gsfD-5j68A:
2.7		 1gsfD-5j68A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 6 ILE A1051
GLU A1069
ASP A1076
LEU A1077
 None
 0.89A 1mt1B-5j68A:
undetectable
1mt1C-5j68A:
undetectable		 1mt1B-5j68A:
11.11
1mt1C-5j68A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		5 / 11 SER A1028
LEU A1108
THR A1030
ILE A1104
VAL A1103
 None
 1.07A 1pkvA-5j68A:
undetectable
1pkvB-5j68A:
undetectable		 1pkvA-5j68A:
9.77
1pkvB-5j68A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		5 / 11 ILE A1104
VAL A1103
SER A1028
LEU A1108
THR A1030
 None
 1.02A 1pkvA-5j68A:
undetectable
1pkvB-5j68A:
undetectable		 1pkvA-5j68A:
9.77
1pkvB-5j68A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		5 / 11 PHE A1105
LEU A1135
VAL A1133
VAL A1032
THR A1137
 None
 1.25A 1q23F-5j68A:
undetectable		 1q23F-5j68A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		3 / 3 SER A1232
GLU A 796
ASP A1111
 None
 0.89A 2avdB-5j68A:
undetectable		 2avdB-5j68A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 7 SER A1203
TYR A1189
VAL A1185
ILE A1215
 None
 1.05A 2x45B-5j68A:
undetectable		 2x45B-5j68A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 7 SER A1203
TYR A1189
VAL A1185
ILE A1215
 None
 1.04A 2x45C-5j68A:
undetectable		 2x45C-5j68A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 7 SER A1203
TYR A1189
VAL A1185
ILE A1215
 None
 1.14A 3bu1A-5j68A:
undetectable		 3bu1A-5j68A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 7 LEU A1078
LEU A1263
ASP A1049
THR A1123
 None
 0.80A 3lm8A-5j68A:
undetectable
3lm8C-5j68A:
undetectable		 3lm8A-5j68A:
16.06
3lm8C-5j68A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 5 LEU A1014
GLN A1040
THR A1045
HIS A1127
 None
 1.49A 3n58C-5j68A:
undetectable		 3n58C-5j68A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 6 GLU A1148
GLU A1149
ALA A1147
ASN A1145
 None
 1.14A 3pgyA-5j68A:
undetectable
3pgyB-5j68A:
undetectable		 3pgyA-5j68A:
20.62
3pgyB-5j68A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		5 / 12 SER A1099
TYR A1101
ILE A1262
VAL A1047
TYR A1050
 None
 1.38A 3sp6A-5j68A:
undetectable		 3sp6A-5j68A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 8 PRO A 767
VAL A 815
LEU A 763
ILE A 753
 None
 0.93A 3u5kD-5j68A:
undetectable		 3u5kD-5j68A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		5 / 12 LEU A 788
LEU A1021
LEU A1034
VAL A1031
THR A1024
 None
 1.29A 3zqtA-5j68A:
undetectable		 3zqtA-5j68A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 7 LEU A 979
TYR A 983
SER A 851
HIS A 852
 None
NAG  A1300 ( 4.1A)
None
NAG  A1300 ( 4.3A)
 1.31A 4arcA-5j68A:
undetectable		 4arcA-5j68A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		4 / 4 ASN A 751
LEU A 727
PHE A 756
TYR A 859
 None
 1.39A 4u14A-5j68A:
undetectable		 4u14A-5j68A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		3 / 3 LEU A1214
ARG A1218
ARG A1217
 None
 0.94A 4yiaB-5j68A:
undetectable		 4yiaB-5j68A:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		5 / 9 ALA A 760
ASP A 720
LEU A 727
LEU A 763
GLU A 725
 None
 1.15A 5dqfA-5j68A:
undetectable		 5dqfA-5j68A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5j68 ASTROTACTIN-2
(Homo
sapiens) 		5 / 12 ILE A 846
GLY A 850
HIS A 848
VAL A 742
ALA A 978
 None
 1.26A 5n0xB-5j68A:
undetectable		 5n0xB-5j68A:
20.31