SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 TRP A 235
LEU A 454
LEU A 407
GLY A 406
PHE A 405
 None
 1.10A 1hvyD-5j6bA:
undetectable		 1hvyD-5j6bA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 PHE A 393
LEU A 426
ALA A 422
GLY A 410
ILE A 257
 None
 1.26A 1kglA-5j6bA:
undetectable		 1kglA-5j6bA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 291
ILE A 292
ALA A 255
ILE A 433
PHE A 390
 None
 1.21A 1xzxX-5j6bA:
undetectable		 1xzxX-5j6bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ALA A 165
THR A 108
PHE A 149
 None
 0.76A 2c6nB-5j6bA:
undetectable		 2c6nB-5j6bA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 SER A 403
SER A 452
LEU A 407
GLY A 406
 None
 0.90A 2j2pA-5j6bA:
undetectable
2j2pC-5j6bA:
undetectable		 2j2pA-5j6bA:
18.88
2j2pC-5j6bA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 SER A 403
SER A 452
LEU A 407
GLY A 406
 None
 0.88A 2j2pD-5j6bA:
undetectable
2j2pF-5j6bA:
undetectable		 2j2pD-5j6bA:
18.88
2j2pF-5j6bA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 TRP A 235
LEU A 454
LEU A 407
GLY A 406
PHE A 405
 None
 1.06A 2kceB-5j6bA:
undetectable		 2kceB-5j6bA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 THR A 228
PHE A 381
GLU A 101
ALA A  91
PHE A 153
 NDP  A 502 (-3.9A)
NDP  A 502 (-4.0A)
None
None
NDP  A 502 (-4.4A)
 0.89A 3apxA-5j6bA:
undetectable		 3apxA-5j6bA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 365
LEU A 305
LEU A 273
VAL A 436
ALA A 385
 None
 1.02A 3r9cA-5j6bA:
undetectable		 3r9cA-5j6bA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 11 ILE A 433
PHE A 393
ALA A 419
PRO A 437
VAL A 400
 None
 1.08A 3tmzA-5j6bA:
undetectable		 3tmzA-5j6bA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 TYR A   8
ASP A  39
ASP A  44
 None
 0.73A 4a6eA-5j6bA:
3.6		 4a6eA-5j6bA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 PHE A 405
ASP A 402
ARG A 377
 None
 0.86A 4eahF-5j6bA:
undetectable		 4eahF-5j6bA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 PHE A 405
ASP A 402
ARG A 377
 None
 0.86A 4eahG-5j6bA:
undetectable		 4eahG-5j6bA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 7 PHE A  80
ASN A  96
GLY A 100
THR A 103
 None
 0.72A 4ejjB-5j6bA:
undetectable		 4ejjB-5j6bA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 GLU A 101
GLN A 283
GLY A 282
SER A 281
 None
 1.02A 4f93B-5j6bA:
undetectable		 4f93B-5j6bA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 4 ALA A  42
ALA A  45
ALA A  46
ALA A  49
 None
 0.11A 4oadA-5j6bA:
undetectable		 4oadA-5j6bA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 4 ALA A  42
ALA A  45
ALA A  46
ALA A  49
 None
 0.07A 4oaeA-5j6bA:
undetectable		 4oaeA-5j6bA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 GLY A 325
PRO A 326
GLN A 283
 None
 0.37A 4oltB-5j6bA:
undetectable		 4oltB-5j6bA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 GLY A 325
PRO A 326
GLN A 283
 None
 0.20A 4qwpB-5j6bA:
undetectable		 4qwpB-5j6bA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 254
GLY A 410
ALA A 274
GLY A 276
TYR A 278
 None
 1.17A 4r29A-5j6bA:
undetectable		 4r29A-5j6bA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 254
GLY A 410
ALA A 274
GLY A 276
TYR A 278
 None
 1.21A 4r29B-5j6bA:
undetectable		 4r29B-5j6bA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 254
GLY A 410
ALA A 274
GLY A 276
TYR A 278
 None
 1.18A 4r29C-5j6bA:
undetectable		 4r29C-5j6bA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 PHE A 439
PRO A 437
VAL A 432
PHE A 412
 None
 1.24A 4w5oA-5j6bA:
3.8		 4w5oA-5j6bA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 SER A 452
GLY A 447
GLY A 429
LEU A 454
GLY A 455
 None
 1.01A 4yvgA-5j6bA:
undetectable		 4yvgA-5j6bA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 PHE A 439
PRO A 437
VAL A 432
PHE A 412
 None
 1.23A 4z4cA-5j6bA:
3.8		 4z4cA-5j6bA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 PHE A 439
PRO A 437
VAL A 432
PHE A 412
 None
 1.25A 4z4dA-5j6bA:
2.4		 4z4dA-5j6bA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 PHE A 439
PRO A 437
VAL A 432
PHE A 412
 None
 1.24A 4z4eA-5j6bA:
2.7		 4z4eA-5j6bA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 254
GLY A 282
SER A 281
SER A 438
TYR A 279
 None
 1.32A 5hfjE-5j6bA:
undetectable		 5hfjE-5j6bA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 301
TYR A 376
VAL A 288
ALA A 385
LEU A 365
 None
 1.04A 5ikrB-5j6bA:
undetectable		 5ikrB-5j6bA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 291
LEU A 305
SER A 438
GLY A 276
TYR A 278
 None
 1.22A 5nnaA-5j6bA:
undetectable		 5nnaA-5j6bA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 291
LEU A 305
SER A 438
GLY A 276
TYR A 278
 None
 1.24A 5nnaB-5j6bA:
undetectable		 5nnaB-5j6bA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 5j6b ALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 291
LEU A 305
SER A 438
GLY A 276
TYR A 278
 None
 1.21A 5nnaD-5j6bA:
undetectable		 5nnaD-5j6bA:
22.15