SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5j6c PUTATIVE REDUCTASE
(Clostridioides
difficile) 		4 / 5 ASP A  55
LEU A 140
ALA A  81
LEU A  80
 None
 0.99A 1nh8A-5j6cA:
undetectable		 1nh8A-5j6cA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 5j6c PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 11 GLU A  50
VAL A 142
SER A 147
VAL A 148
ASP A 133
 None
 1.31A 2c12B-5j6cA:
undetectable		 2c12B-5j6cA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5j6c PUTATIVE REDUCTASE
(Clostridioides
difficile) 		6 / 12 LEU A  60
ILE A 151
ILE A 119
PHE A  74
ILE A 105
VAL A  25
 None
None
FMN  A 201 (-4.8A)
FMN  A 201 (-4.7A)
None
None
 1.50A 2ygoA-5j6cA:
undetectable		 2ygoA-5j6cA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5j6c PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 11 ALA A  37
ILE A  33
ILE A  52
ILE A 152
ILE A 105
 None
 1.00A 3ebzA-5j6cA:
undetectable		 3ebzA-5j6cA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 5j6c PUTATIVE REDUCTASE
(Clostridioides
difficile) 		4 / 8 ALA A  86
ASP A  97
ILE A  52
VAL A 121
 None
 0.78A 3nu9A-5j6cA:
undetectable		 3nu9A-5j6cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 5j6c PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 9 ALA A  37
ILE A  33
ILE A  52
ILE A 152
ILE A 105
 None
 0.95A 3s43A-5j6cA:
undetectable		 3s43A-5j6cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 5j6c PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 9 ALA A  81
ILE A 119
ILE A  61
ILE A 136
ILE A 151
 None
FMN  A 201 (-4.8A)
None
None
None
 0.96A 3s43A-5j6cA:
undetectable		 3s43A-5j6cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 5j6c PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 9 ALA A  37
ILE A  33
ILE A  52
ILE A 152
ILE A 105
 None
 1.02A 3s45A-5j6cA:
undetectable		 3s45A-5j6cA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5j6c PUTATIVE REDUCTASE
(Clostridioides
difficile) 		5 / 12 VAL A 142
LEU A 140
ARG A 137
ILE A 151
VAL A 121
 None
 1.10A 4o1zB-5j6cA:
undetectable		 4o1zB-5j6cA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5j6c PUTATIVE REDUCTASE
(Clostridioides
difficile) 		4 / 8 LEU A  63
VAL A 148
TYR A 135
LEU A 140
 None
 1.10A 4pwdC-5j6cA:
undetectable		 4pwdC-5j6cA:
14.87