SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
4 / 4 ASP A 293
HIS A 296
ARG A 150
GLU A 322
None
MN  A 401 ( 3.5A)
None
MN  A 401 (-1.9A)
1.45A 1lqtA-5j6fA:
1.5
1lqtA-5j6fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1426_0
(FPRA)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
4 / 4 ASP A 293
HIS A 296
ARG A 150
GLU A 322
None
MN  A 401 ( 3.5A)
None
MN  A 401 (-1.9A)
1.43A 1lquA-5j6fA:
1.3
1lquA-5j6fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
5 / 10 ILE A 248
ALA A 245
ALA A 244
ASN A 211
ILE A 195
None
1.06A 2aclC-5j6fA:
undetectable
2aclC-5j6fA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
5 / 10 ILE A 248
ALA A 245
ALA A 244
ASN A 214
ILE A 195
None
1.12A 2aclC-5j6fA:
undetectable
2aclC-5j6fA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
4 / 8 PRO A 306
ALA A 308
ALA A 311
THR A 298
None
0.86A 3dtuC-5j6fA:
undetectable
3dtuD-5j6fA:
undetectable
3dtuC-5j6fA:
18.67
3dtuD-5j6fA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
4 / 7 ARG A  27
VAL A  31
MET A  54
GLN A  86
PRE  A 404 (-3.4A)
PRE  A 404 ( 4.9A)
PRE  A 404 (-3.6A)
PRE  A 404 (-3.3A)
0.72A 3hgxA-5j6fA:
10.5
3hgxA-5j6fA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_B_SALB104_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
5 / 9 ARG A  27
VAL A  31
ARG A  50
MET A  54
GLN A  86
PRE  A 404 (-3.4A)
PRE  A 404 ( 4.9A)
PRE  A 404 (-4.6A)
PRE  A 404 (-3.6A)
PRE  A 404 (-3.3A)
0.75A 3hgxB-5j6fA:
10.5
3hgxB-5j6fA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
5 / 8 ARG A  27
VAL A  31
ARG A  50
MET A  54
GLN A  86
PRE  A 404 (-3.4A)
PRE  A 404 ( 4.9A)
PRE  A 404 (-4.6A)
PRE  A 404 (-3.6A)
PRE  A 404 (-3.3A)
0.65A 3remA-5j6fA:
10.6
3remA-5j6fA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
5 / 8 ARG A  27
VAL A  31
ARG A  50
MET A  54
GLN A  86
PRE  A 404 (-3.4A)
PRE  A 404 ( 4.9A)
PRE  A 404 (-4.6A)
PRE  A 404 (-3.6A)
PRE  A 404 (-3.3A)
0.69A 3remB-5j6fA:
10.5
3remB-5j6fA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
5 / 10 ARG A  27
VAL A  31
ARG A  50
MET A  54
GLN A  86
PRE  A 404 (-3.4A)
PRE  A 404 ( 4.9A)
PRE  A 404 (-4.6A)
PRE  A 404 (-3.6A)
PRE  A 404 (-3.3A)
0.72A 3retA-5j6fA:
10.7
3retB-5j6fA:
10.2
3retA-5j6fA:
17.46
3retB-5j6fA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_B_SALB201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
5 / 9 ARG A  27
VAL A  31
ARG A  50
MET A  54
GLN A  86
PRE  A 404 (-3.4A)
PRE  A 404 ( 4.9A)
PRE  A 404 (-4.6A)
PRE  A 404 (-3.6A)
PRE  A 404 (-3.3A)
0.69A 3retB-5j6fA:
10.2
3retB-5j6fA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
5 / 11 LEU A  57
SER A  59
THR A  68
GLY A  64
ASP A  63
None
1.44A 3sfuC-5j6fA:
undetectable
3sfuC-5j6fA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
4 / 6 LEU A 148
VAL A 122
MET A 320
PHE A 291
None
1.08A 3soaA-5j6fA:
undetectable
3soaA-5j6fA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
4 / 7 GLY A 315
ALA A 316
ASP A 317
ILE A 281
None
0.60A 3t3cA-5j6fA:
undetectable
3t3cA-5j6fA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
4 / 7 SER A 332
GLN A 164
PHE A 163
ASP A 162
None
None
None
SO4  A 402 ( 4.9A)
1.40A 4kcnB-5j6fA:
undetectable
4kcnB-5j6fA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
3 / 3 GLY A 152
GLY A 151
GLN A 206
None
0.48A 5imsA-5j6fA:
undetectable
5imsA-5j6fA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
4 / 7 GLY A 315
ALA A 316
ASP A 317
ILE A 281
None
0.58A 5kqyB-5j6fA:
undetectable
5kqyB-5j6fA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
4 / 8 GLY A 315
ALA A 316
ASP A 317
ILE A 281
None
0.61A 5kr1B-5j6fA:
undetectable
5kr1B-5j6fA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus
sp.
GHH01)
4 / 7 VAL A 329
PRO A 325
ILE A 340
SER A 130
None
1.00A 5vkqA-5j6fA:
undetectable
5vkqD-5j6fA:
undetectable
5vkqA-5j6fA:
12.47
5vkqD-5j6fA:
12.47