SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		5 / 10 LEU A2131
ALA A2181
ASP A2201
ILE A2209
GLY A2207
 None
 1.24A 1d4sA-5j6oA:
undetectable		 1d4sA-5j6oA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		3 / 3 THR A1993
PRO A2054
THR A2053
 None
 0.92A 1dscC-5j6oA:
undetectable		 1dscC-5j6oA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 6 VAL A2000
LEU A2166
PHE A2216
MET A2213
 None
 1.07A 1x8vA-5j6oA:
undetectable		 1x8vA-5j6oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 7 MET A2132
PRO A2163
VAL A2000
TRP A2002
 None
 1.31A 2hrcA-5j6oA:
undetectable		 2hrcA-5j6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 5 MET A2132
PRO A2163
VAL A2000
TRP A2002
 None
 1.28A 2pnjA-5j6oA:
0.0		 2pnjA-5j6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		5 / 11 MET A2132
SER A2139
PRO A2163
VAL A2000
TRP A2002
 None
 1.32A 3aqiA-5j6oA:
undetectable		 3aqiA-5j6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		5 / 12 GLU A2178
HIS A2095
LEU A2136
ILE A2200
HIS A1960
 None
 1.48A 3gwxB-5j6oA:
undetectable		 3gwxB-5j6oA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1480_0
(MJ0495-LIKE PROTEIN)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 4 LYS A2100
GLU A2141
ILE A2075
SER A2076
 None
 1.24A 4ac9C-5j6oA:
undetectable		 4ac9C-5j6oA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 4 LYS A2100
GLU A2141
ILE A2075
SER A2076
 None
 1.23A 4acaC-5j6oA:
undetectable		 4acaC-5j6oA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 4 LYS A2100
GLU A2141
ILE A2075
SER A2076
 None
 1.30A 4acbC-5j6oA:
undetectable		 4acbC-5j6oA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 7 MET A2132
ILE A2171
VAL A2000
TRP A2002
 None
 1.12A 4f4dA-5j6oA:
undetectable		 4f4dA-5j6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		5 / 8 MET A2132
ILE A2171
PRO A2163
VAL A2000
TRP A2002
 None
 1.33A 4f4dB-5j6oA:
undetectable		 4f4dB-5j6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 7 MET A2132
PRO A2163
VAL A2000
TRP A2002
 None
 1.29A 4kmmA-5j6oA:
undetectable		 4kmmA-5j6oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_1
(ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		5 / 9 ILE A2031
THR A2017
SER A2033
TYR A1973
PRO A1969
 None
 1.48A 5alcH-5j6oA:
0.0		 5alcH-5j6oA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		3 / 3 TYR A2102
LYS A2111
LYS A2100
 None
 1.21A 5dbyA-5j6oA:
undetectable		 5dbyA-5j6oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 8 SER A1947
SER A1948
ALA A1980
SER A1979
 None
 0.95A 5l5fY-5j6oA:
undetectable
5l5fZ-5j6oA:
undetectable		 5l5fY-5j6oA:
21.25
5l5fZ-5j6oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5j6o PUTATIVE POLYKETIDE
SYNTHASE
(Brevibacillus
brevis) 		4 / 6 PRO A1969
LEU A2127
PHE A2125
LEU A2131
 None
 0.99A 5tl8A-5j6oA:
undetectable		 5tl8A-5j6oA:
21.28