SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		5 / 12 GLY A 429
GLY A 431
ASP A 405
PHE A 407
ASN A 454
 None
 1.12A 1xdsA-5j6qA:
undetectable		 1xdsA-5j6qA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		4 / 6 ALA A 440
TYR A 515
ILE A 438
ILE A 552
 None
 1.13A 2dcfA-5j6qA:
undetectable		 2dcfA-5j6qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		5 / 11 SER A 295
GLU A 582
VAL A 291
GLY A 583
ILE A 584
 None
 1.06A 2uxpB-5j6qA:
undetectable		 2uxpB-5j6qA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		5 / 10 ILE A 320
LEU A 321
VAL A 382
GLY A 323
GLY A 377
 None
 1.20A 2wd9C-5j6qA:
4.1		 2wd9C-5j6qA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		4 / 7 ALA A 440
TYR A 515
ILE A 438
ILE A 552
 None
 1.13A 2zm7A-5j6qA:
undetectable		 2zm7A-5j6qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		5 / 12 ILE A 344
LEU A 535
ASN A 507
ILE A 327
ALA A 326
 None
 1.08A 3a50D-5j6qA:
undetectable		 3a50D-5j6qA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		3 / 3 ASP A  51
ASN A  52
SER A  73
 None
 0.98A 3lslA-5j6qA:
undetectable
3lslD-5j6qA:
undetectable		 3lslA-5j6qA:
18.98
3lslD-5j6qA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		4 / 6 TYR A 522
ILE A 580
SER A 547
SER A 548
 SO4  A 707 (-3.9A)
None
None
SO4  A 707 ( 4.6A)
 0.97A 3pmzD-5j6qA:
undetectable		 3pmzD-5j6qA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		3 / 3 ASN A 532
ALA A 433
ARG A 503
 None
None
SO4  A 702 (-3.9A)
 0.62A 3tj7C-5j6qA:
undetectable
3tj7D-5j6qA:
undetectable		 3tj7C-5j6qA:
15.29
3tj7D-5j6qA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		4 / 6 LEU A 223
TYR A 221
LYS A 216
GLU A 261
 None
 0.88A 4f3tA-5j6qA:
undetectable		 4f3tA-5j6qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		5 / 12 ILE A 195
ALA A 197
LEU A 223
VAL A 217
ILE A 263
 None
 1.08A 4km2A-5j6qA:
undetectable		 4km2A-5j6qA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		3 / 3 VAL A 382
SER A 383
THR A 386
 None
 0.42A 4luhA-5j6qA:
undetectable		 4luhA-5j6qA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		4 / 5 GLY A 377
ILE A 413
LYS A 415
GLN A 416
 None
 1.07A 4ma8C-5j6qA:
undetectable		 4ma8C-5j6qA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		5 / 12 LEU A 280
ILE A 251
LEU A 223
GLY A 210
VAL A 217
 None
 0.83A 4nkvB-5j6qA:
undetectable		 4nkvB-5j6qA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		3 / 3 LEU A 147
ASP A 151
TYR A  98
 None
 0.35A 4qc6B-5j6qA:
undetectable		 4qc6B-5j6qA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		5 / 9 THR A 302
ALA A 541
ALA A 545
GLY A 581
ALA A 524
 None
 1.12A 4qvqK-5j6qA:
undetectable
4qvqL-5j6qA:
undetectable		 4qvqK-5j6qA:
17.59
4qvqL-5j6qA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		5 / 9 THR A 302
ALA A 541
ALA A 545
GLY A 581
ALA A 524
 None
 1.12A 4qvqY-5j6qA:
undetectable
4qvqZ-5j6qA:
undetectable		 4qvqY-5j6qA:
17.59
4qvqZ-5j6qA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		5 / 12 PHE A 249
PHE A 225
LEU A 280
LEU A 276
LEU A 200
 None
 1.19A 4xumA-5j6qA:
undetectable		 4xumA-5j6qA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		4 / 7 LEU A 223
TYR A 221
LYS A 216
GLU A 261
 None
 0.90A 4z4fA-5j6qA:
undetectable		 4z4fA-5j6qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		4 / 6 LEU A 223
TYR A 221
LYS A 216
GLU A 261
 None
 0.90A 4z4gA-5j6qA:
5.0		 4z4gA-5j6qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		4 / 7 LEU A 223
TYR A 221
LYS A 216
GLU A 261
 None
 0.92A 5t7bA-5j6qA:
undetectable		 5t7bA-5j6qA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		5 / 12 SER A 307
ILE A 319
LEU A 321
ALA A 303
LEU A 346
 None
 1.34A 5zwrB-5j6qA:
undetectable		 5zwrB-5j6qA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5j6q CELL WALL BINDING
PROTEIN CWP8
(Clostridioides
difficile) 		6 / 12 ILE A 584
ALA A 585
ALA A 588
LEU A 559
ILE A 552
LEU A 577
 None
SO4  A 705 (-3.8A)
None
None
None
None
 1.49A 6a60D-5j6qA:
undetectable		 6a60D-5j6qA:
7.56