SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 TRP A 955
ARG A 674
THR A 951
 None
 0.83A 1df7A-5j6sA:
undetectable		 1df7A-5j6sA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 TYR A 592
PHE A 623
THR A 618
LEU A 614
 None
 1.14A 1ea1A-5j6sA:
undetectable		 1ea1A-5j6sA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 4 THR A 676
LEU A 675
VAL A 666
LEU A 662
 None
 1.08A 1fbmB-5j6sA:
undetectable		 1fbmB-5j6sA:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 11 LEU A 757
LEU A 754
ALA A 753
LEU A 697
HIS A 708
 None
 1.06A 1g50A-5j6sA:
undetectable		 1g50A-5j6sA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 GLN A 375
TYR A 344
ARG A 345
 None
 0.81A 1gtbA-5j6sA:
undetectable		 1gtbA-5j6sA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 10 LEU A 757
LEU A 754
ALA A 753
LEU A 697
HIS A 708
 None
 1.01A 1gwrA-5j6sA:
undetectable		 1gwrA-5j6sA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.75A 1j36A-5j6sA:
7.3		 1j36A-5j6sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.75A 1j36B-5j6sA:
7.3		 1j36B-5j6sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 11 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.73A 1j37A-5j6sA:
4.8		 1j37A-5j6sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 11 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.73A 1j37B-5j6sA:
7.3		 1j37B-5j6sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.74A 1o86A-5j6sA:
7.4		 1o86A-5j6sA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 10 THR A 197
PHE A  91
LEU A  80
PHE A 168
VAL A  82
 None
 1.39A 1q23K-5j6sA:
undetectable		 1q23K-5j6sA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 TYR A 184
ARG A 229
HIS A 230
ASP A 291
 None
 1.30A 1s3zA-5j6sA:
undetectable
1s3zB-5j6sA:
undetectable		 1s3zA-5j6sA:
10.26
1s3zB-5j6sA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 ILE A 267
ASP A 198
PHE A 199
 None
6GA  A1015 (-3.1A)
None
 0.58A 1uwjB-5j6sA:
undetectable		 1uwjB-5j6sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.99A 1v7zD-5j6sA:
2.5		 1v7zD-5j6sA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.99A 1v7zE-5j6sA:
2.5		 1v7zE-5j6sA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.98A 1v7zF-5j6sA:
undetectable		 1v7zF-5j6sA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		6 / 12 ALA A 335
HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 6GA  A1015 (-4.7A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.73A 2c6nA-5j6sA:
7.3		 2c6nA-5j6sA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.82A 2c6nB-5j6sA:
undetectable		 2c6nB-5j6sA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.70A 2eijN-5j6sA:
undetectable
2eijW-5j6sA:
undetectable		 2eijN-5j6sA:
20.29
2eijW-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.70A 2eikA-5j6sA:
undetectable
2eikJ-5j6sA:
undetectable		 2eikA-5j6sA:
20.29
2eikJ-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.69A 2eikN-5j6sA:
undetectable
2eikW-5j6sA:
undetectable		 2eikN-5j6sA:
20.29
2eikW-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.68A 2eilN-5j6sA:
undetectable
2eilW-5j6sA:
undetectable		 2eilN-5j6sA:
20.29
2eilW-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 9 LEU A 840
LEU A 838
PHE A 875
LEU A 859
ILE A 862
 None
 1.19A 2f7aB-5j6sA:
undetectable		 2f7aB-5j6sA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 LEU A 855
LEU A 858
SER A 831
TRP A 805
 None
 0.92A 2hc4A-5j6sA:
undetectable		 2hc4A-5j6sA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUB_A_2TNA134_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 4 LEU A 761
ILE A 767
HIS A 708
LYS A 723
 None
 1.46A 2oubA-5j6sA:
1.6		 2oubA-5j6sA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 10 TYR A 344
ALA A 299
ALA A 302
THR A 407
VAL A 404
 None
 1.33A 2wuzA-5j6sA:
undetectable		 2wuzA-5j6sA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 10 TYR A 344
ALA A 299
ALA A 302
THR A 407
VAL A 404
 None
 1.31A 2wuzB-5j6sA:
2.5		 2wuzB-5j6sA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 GLU A 337
HIS A 370
GLU A 371
 6GA  A1015 (-4.0A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.79A 2x45B-5j6sA:
undetectable		 2x45B-5j6sA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 GLU A 337
HIS A 370
GLU A 371
 6GA  A1015 (-4.0A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.79A 2x45C-5j6sA:
undetectable		 2x45C-5j6sA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 11 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.69A 2x8zA-5j6sA:
6.3		 2x8zA-5j6sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.71A 2x91A-5j6sA:
7.3		 2x91A-5j6sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.94A 3a6jB-5j6sA:
2.6		 3a6jB-5j6sA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.95A 3a6jC-5j6sA:
2.4		 3a6jC-5j6sA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.97A 3a6jE-5j6sA:
undetectable		 3a6jE-5j6sA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.94A 3a6jF-5j6sA:
2.4		 3a6jF-5j6sA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.72A 3ag3N-5j6sA:
undetectable
3ag3W-5j6sA:
undetectable		 3ag3N-5j6sA:
20.29
3ag3W-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.73A 3asnN-5j6sA:
undetectable
3asnW-5j6sA:
undetectable		 3asnN-5j6sA:
20.29
3asnW-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 917
LEU A 921
LEU A 928
THR A 901
GLU A 878
 None
 0.92A 3cwkA-5j6sA:
undetectable		 3cwkA-5j6sA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 4 ILE A 286
THR A 365
LYS A 361
TYR A 344
 None
 1.47A 3elzA-5j6sA:
1.7		 3elzA-5j6sA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 SER A 498
TYR A 481
PHE A 395
LEU A 391
 None
 0.76A 3i45A-5j6sA:
undetectable		 3i45A-5j6sA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 LEU A 791
TRP A 777
GLY A 782
 None
 0.75A 3l35A-5j6sA:
undetectable
3l35H-5j6sA:
undetectable		 3l35A-5j6sA:
6.27
3l35H-5j6sA:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 LEU A 791
TRP A 777
GLY A 782
 None
 0.79A 3l35B-5j6sA:
undetectable
3l35K-5j6sA:
undetectable		 3l35B-5j6sA:
6.27
3l35K-5j6sA:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 4 GLY A 175
GLU A 177
ASP A 893
ASP A 174
 None
 1.34A 3mb5A-5j6sA:
undetectable		 3mb5A-5j6sA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 LEU A 757
LEU A 754
ALA A 753
LEU A 697
HIS A 708
 None
 1.00A 3olsA-5j6sA:
undetectable		 3olsA-5j6sA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 314
TYR A 313
LEU A 482
ALA A 490
LEU A 391
 None
 1.23A 3ozuA-5j6sA:
undetectable		 3ozuA-5j6sA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 LEU A 757
LEU A 754
ALA A 753
LEU A 697
HIS A 708
 None
 1.01A 3q95B-5j6sA:
undetectable		 3q95B-5j6sA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 THR A 197
PHE A  91
LEU A  80
PHE A 168
VAL A  82
 None
 1.34A 3u9fJ-5j6sA:
undetectable
3u9fK-5j6sA:
undetectable		 3u9fJ-5j6sA:
12.73
3u9fK-5j6sA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 6 ASP A 308
GLY A 281
LEU A 304
GLU A 311
 None
 1.10A 3w9tB-5j6sA:
undetectable		 3w9tB-5j6sA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 6 ASP A 308
GLY A 281
LEU A 304
GLU A 311
 None
 1.10A 3w9tE-5j6sA:
undetectable		 3w9tE-5j6sA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 6 ASP A 308
GLY A 281
LEU A 304
GLU A 311
 None
 1.10A 3w9tF-5j6sA:
undetectable		 3w9tF-5j6sA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 ASN A 948
TRP A 944
ASP A 678
 None
 0.95A 4a7tA-5j6sA:
undetectable
4a7tF-5j6sA:
undetectable		 4a7tA-5j6sA:
11.05
4a7tF-5j6sA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 6 GLU A 410
TYR A 298
HIS A 297
VAL A 284
 None
 1.23A 4a97I-5j6sA:
4.4		 4a97I-5j6sA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 11 HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.76A 4c2pA-5j6sA:
7.4		 4c2pA-5j6sA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 9 GLY A 334
HIS A 370
GLU A 371
GLU A 393
TYR A 455
 6GA  A1015 (-3.7A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.39A 4dprA-5j6sA:
31.8		 4dprA-5j6sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 LYS A 427
THR A 933
ILE A 898
 None
 0.85A 4e0fB-5j6sA:
1.3		 4e0fB-5j6sA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 9 ILE A 316
TYR A 318
GLN A 375
VAL A 381
VAL A 257
 None
None
None
None
NAG  A1004 (-3.8A)
 1.20A 4g1bC-5j6sA:
3.7		 4g1bC-5j6sA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 LYS A 361
LEU A 411
ALA A 358
 None
 0.73A 4iizA-5j6sA:
undetectable		 4iizA-5j6sA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 ILE A  97
ALA A 218
ARG A 205
PHE A 211
VAL A  99
 None
 1.08A 4kfjB-5j6sA:
undetectable		 4kfjB-5j6sA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 4 ILE A 224
VAL A 196
VAL A 268
ARG A 226
 None
 1.13A 4m6tA-5j6sA:
undetectable		 4m6tA-5j6sA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 5 PHE A 211
HIS A 111
PHE A 216
PRO A 443
 None
 1.37A 4o8zA-5j6sA:
undetectable		 4o8zA-5j6sA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 6 LEU A 462
HIS A 374
HIS A 370
GLU A 393
 None
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
 0.99A 4pahA-5j6sA:
undetectable		 4pahA-5j6sA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 LEU A 757
LEU A 754
ALA A 753
LEU A 697
HIS A 708
 None
 1.04A 4pxmA-5j6sA:
undetectable		 4pxmA-5j6sA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 6 GLU A 452
ILE A 930
THR A 933
TYR A 892
 6GA  A1015 ( 4.8A)
None
None
6GA  A1015 (-3.8A)
 1.28A 4qwpA-5j6sA:
undetectable		 4qwpA-5j6sA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 5 GLU A 452
ILE A 930
THR A 933
TYR A 892
 6GA  A1015 ( 4.8A)
None
None
6GA  A1015 (-3.8A)
 1.32A 4qwpB-5j6sA:
undetectable		 4qwpB-5j6sA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 ALA A 265
ALA A 327
ILE A 326
GLY A 340
GLN A 375
 None
 1.04A 4r38A-5j6sA:
undetectable		 4r38A-5j6sA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 ALA A 265
ALA A 327
ILE A 326
GLY A 340
GLN A 375
 None
 1.04A 4r38B-5j6sA:
undetectable		 4r38B-5j6sA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 ALA A 265
ALA A 327
ILE A 326
GLY A 340
GLN A 375
 None
 1.00A 4r38C-5j6sA:
undetectable		 4r38C-5j6sA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 ALA A 265
ALA A 327
ILE A 326
GLY A 340
GLN A 375
 None
 1.02A 4r38D-5j6sA:
undetectable		 4r38D-5j6sA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 ALA A 265
ALA A 327
ILE A 326
GLY A 340
GLN A 375
 None
 0.93A 4r3aB-5j6sA:
undetectable		 4r3aB-5j6sA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		6 / 12 HIS A 370
GLU A 371
HIS A 374
TRP A 386
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
None
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.56A 4r7lA-5j6sA:
41.2		 4r7lA-5j6sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		6 / 12 HIS A 370
GLU A 371
HIS A 374
TRP A 386
PHE A 450
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
None
6GA  A1015 (-3.7A)
6GA  A1015 (-4.0A)
 1.31A 4r7lA-5j6sA:
41.2		 4r7lA-5j6sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 ASP A 415
ARG A 659
PRO A 656
 None
 0.89A 4wanC-5j6sA:
1.9		 4wanC-5j6sA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 LEU A 722
ASN A 959
LEU A 956
LEU A 952
 None
 0.73A 4wg0B-5j6sA:
undetectable
4wg0C-5j6sA:
undetectable		 4wg0B-5j6sA:
1.97
4wg0C-5j6sA:
1.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 ASN A 959
LEU A 956
LEU A 952
LEU A 722
 None
 0.71A 4wg0L-5j6sA:
undetectable
4wg0M-5j6sA:
undetectable		 4wg0L-5j6sA:
1.97
4wg0M-5j6sA:
1.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 LYS A 223
ARG A 225
HIS A  83
 None
None
NAG  A1002 (-3.9A)
 1.22A 4zbrA-5j6sA:
3.6		 4zbrA-5j6sA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 ARG A 877
LYS A 910
GLU A 913
 None
 0.59A 5d0yA-5j6sA:
undetectable		 5d0yA-5j6sA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 ASN A 714
SER A 716
SER A 719
 NAG  A1012 (-1.9A)
None
None
 0.78A 5gsnA-5j6sA:
undetectable		 5gsnA-5j6sA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 ILE A 898
HIS A 860
LEU A 859
ALA A 856
 None
 0.96A 5hrqE-5j6sA:
undetectable
5hrqF-5j6sA:
undetectable
5hrqJ-5j6sA:
undetectable		 5hrqE-5j6sA:
1.80
5hrqF-5j6sA:
2.61
5hrqJ-5j6sA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 HIS A 664
HIS A 634
ILE A 632
VAL A 633
 None
 1.24A 5kkzC-5j6sA:
undetectable
5kkzE-5j6sA:
undetectable		 5kkzC-5j6sA:
11.68
5kkzE-5j6sA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 HIS A 634
ILE A 632
VAL A 633
HIS A 664
 None
 1.19A 5kkzK-5j6sA:
undetectable
5kkzQ-5j6sA:
undetectable		 5kkzK-5j6sA:
17.92
5kkzQ-5j6sA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 4 GLN A 932
THR A 933
GLU A 448
LEU A 921
 None
 1.37A 5m66A-5j6sA:
undetectable		 5m66A-5j6sA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 TYR A 313
PHE A 314
ALA A 396
GLY A 394
 None
None
ZN  A1001 ( 4.5A)
None
 1.07A 5uxdA-5j6sA:
undetectable		 5uxdA-5j6sA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.73A 5xdxN-5j6sA:
undetectable
5xdxW-5j6sA:
undetectable		 5xdxN-5j6sA:
20.29
5xdxW-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 5 GLN A 853
TYR A 180
GLU A 346
ASP A 291
 None
 1.21A 5yf0A-5j6sA:
0.3		 5yf0A-5j6sA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.79A 5zcoA-5j6sA:
undetectable
5zcoJ-5j6sA:
undetectable		 5zcoA-5j6sA:
20.29
5zcoJ-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 ILE A 328
VAL A 196
THR A 197
ILE A 267
PRO A 201
 None
None
None
None
6GA  A1015 ( 4.4A)
 1.19A 6hlpA-5j6sA:
undetectable		 6hlpA-5j6sA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 6 ILE A 328
ALA A 335
ARG A 345
ASP A 893
 None
6GA  A1015 (-4.7A)
None
None
 0.93A 6hu9m-5j6sA:
undetectable
6hu9q-5j6sA:
undetectable		 6hu9m-5j6sA:
20.56
6hu9q-5j6sA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 6 LEU A 462
HIS A 374
HIS A 370
GLU A 393
 None
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
 1.04A 6pahA-5j6sA:
undetectable		 6pahA-5j6sA:
16.50