SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 5j74 SCFV AM2.2
(Homo
sapiens) 		3 / 3 ALA A  33
VAL A  97
TRP A  36
 None
6GN  A 302 ( 4.7A)
None
 0.95A 1gmkA-5j74A:
undetectable
1gmkB-5j74A:
undetectable		 1gmkA-5j74A:
4.26
1gmkB-5j74A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 5j74 SCFV AM2.2
(Homo
sapiens) 		4 / 7 GLU A  10
PHE A  64
MET A  81
ALA A  79
 None
 1.30A 1linA-5j74A:
undetectable		 1linA-5j74A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5j74 SCFV AM2.2
(Homo
sapiens) 		4 / 7 GLU A 226
VAL A 251
ARG A 204
VAL A 160
 None
 1.04A 1zzrA-5j74A:
undetectable
1zzrB-5j74A:
undetectable		 1zzrA-5j74A:
19.57
1zzrB-5j74A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5j74 SCFV AM2.2
(Homo
sapiens) 		4 / 7 VAL A 251
ARG A 204
VAL A 160
GLU A 226
 None
 1.00A 3jx2A-5j74A:
undetectable
3jx2B-5j74A:
undetectable		 3jx2A-5j74A:
19.71
3jx2B-5j74A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5j74 SCFV AM2.2
(Homo
sapiens) 		4 / 7 VAL A 251
ARG A 204
VAL A 160
GLU A 226
 None
 1.03A 3jx5A-5j74A:
undetectable
3jx5B-5j74A:
undetectable		 3jx5A-5j74A:
19.71
3jx5B-5j74A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5j74 SCFV AM2.2
(Homo
sapiens) 		4 / 7 VAL A 251
ARG A 204
VAL A 160
GLU A 226
 None
 0.97A 3jx6A-5j74A:
undetectable
3jx6B-5j74A:
undetectable		 3jx6A-5j74A:
19.95
3jx6B-5j74A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5j74 SCFV AM2.2
(Homo
sapiens) 		4 / 7 VAL A 251
ARG A 204
VAL A 160
GLU A 226
 None
 0.96A 3nljA-5j74A:
undetectable
3nljB-5j74A:
undetectable		 3nljA-5j74A:
19.95
3nljB-5j74A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5j74 SCFV AM2.2
(Homo
sapiens) 		4 / 7 VAL A 251
ARG A 204
VAL A 160
GLU A 226
 None
 1.00A 3nlpA-5j74A:
undetectable
3nlpB-5j74A:
undetectable		 3nlpA-5j74A:
19.71
3nlpB-5j74A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5j74 SCFV AM2.2
(Homo
sapiens) 		4 / 8 VAL A 251
ARG A 204
VAL A 160
GLU A 226
 None
 0.97A 3nlqA-5j74A:
undetectable
3nlqB-5j74A:
undetectable		 3nlqA-5j74A:
19.71
3nlqB-5j74A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5j74 SCFV AM2.2
(Homo
sapiens) 		4 / 7 GLU A 226
VAL A 251
ARG A 204
VAL A 160
 None
 1.00A 3nlqA-5j74A:
undetectable
3nlqB-5j74A:
undetectable		 3nlqA-5j74A:
19.71
3nlqB-5j74A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5j74 SCFV AM2.2
(Homo
sapiens) 		4 / 7 VAL A 251
ARG A 204
VAL A 160
GLU A 226
 None
 1.00A 3nlrA-5j74A:
undetectable
3nlrB-5j74A:
undetectable		 3nlrA-5j74A:
19.71
3nlrB-5j74A:
19.71