SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j84'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 7 GLY A 274
ALA A 400
THR A 377
THR A 308
None
0.83A 1c9sT-5j84A:
undetectable
1c9sU-5j84A:
undetectable
1c9sT-5j84A:
8.03
1c9sU-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 8 GLY A 274
ALA A 400
THR A 377
THR A 308
None
0.82A 1c9sU-5j84A:
undetectable
1c9sV-5j84A:
undetectable
1c9sU-5j84A:
8.03
1c9sV-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 7 GLY A 274
ALA A 400
THR A 377
THR A 308
None
0.80A 1gtfL-5j84A:
undetectable
1gtfM-5j84A:
undetectable
1gtfL-5j84A:
8.03
1gtfM-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 8 GLY A 274
ALA A 400
THR A 377
THR A 308
None
0.78A 1gtfN-5j84A:
undetectable
1gtfO-5j84A:
undetectable
1gtfN-5j84A:
8.03
1gtfO-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 7 GLY A 274
ALA A 400
THR A 377
THR A 308
None
0.80A 1gtnA-5j84A:
undetectable
1gtnK-5j84A:
undetectable
1gtnA-5j84A:
8.03
1gtnK-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.13A 1gtnB-5j84A:
undetectable
1gtnC-5j84A:
undetectable
1gtnB-5j84A:
8.03
1gtnC-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 ALA A 401
GLY A 274
ALA A 400
THR A 377
THR A 308
None
1.05A 1gtnH-5j84A:
undetectable
1gtnI-5j84A:
undetectable
1gtnH-5j84A:
8.03
1gtnI-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.10A 1gtnH-5j84A:
undetectable
1gtnI-5j84A:
undetectable
1gtnH-5j84A:
8.03
1gtnI-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 7 THR A 377
SER A 315
GLY A 381
ILE A 382
None
1.00A 1gtnJ-5j84A:
undetectable
1gtnK-5j84A:
undetectable
1gtnJ-5j84A:
8.03
1gtnK-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 9 VAL A 383
GLY A 381
ILE A 382
THR A 377
SER A 315
None
1.26A 1gtnL-5j84A:
undetectable
1gtnM-5j84A:
undetectable
1gtnL-5j84A:
8.03
1gtnM-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 11 GLY A 274
ALA A 400
THR A 377
THR A 308
ALA A 401
None
0.97A 1gtnM-5j84A:
undetectable
1gtnN-5j84A:
undetectable
1gtnM-5j84A:
8.03
1gtnN-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 11 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.09A 1gtnM-5j84A:
undetectable
1gtnN-5j84A:
undetectable
1gtnM-5j84A:
8.03
1gtnN-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 9 GLY A 274
ALA A 400
THR A 377
THR A 308
ALA A 401
None
0.94A 1gtnQ-5j84A:
undetectable
1gtnR-5j84A:
undetectable
1gtnQ-5j84A:
8.03
1gtnR-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.09A 1gtnU-5j84A:
undetectable
1gtnV-5j84A:
undetectable
1gtnU-5j84A:
8.03
1gtnV-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 LEU A 532
LEU A 528
LEU A 501
GLU A 494
LEU A 389
None
1.33A 1ie4A-5j84A:
undetectable
1ie4C-5j84A:
undetectable
1ie4A-5j84A:
14.08
1ie4C-5j84A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 4 GLY A 241
LEU A 239
GLY A  73
ARG A 242
None
1.05A 1j7kA-5j84A:
2.3
1j7kA-5j84A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 7 VAL A  74
SER A 145
LEU A 123
ALA A 138
None
0.71A 1j8uA-5j84A:
undetectable
1j8uA-5j84A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 LEU A 104
PHE A 263
ALA A 287
ALA A 285
LEU A 563
None
1.30A 1kt5A-5j84A:
undetectable
1kt5A-5j84A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 6 SER A 133
ASN A 103
LEU A 563
ASP A 562
KCX  A 129 ( 2.8A)
None
None
None
1.14A 1mxdA-5j84A:
undetectable
1mxdA-5j84A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 8 SER A 133
ASN A 103
LEU A 563
ASP A 562
KCX  A 129 ( 2.8A)
None
None
None
1.14A 1mxgA-5j84A:
undetectable
1mxgA-5j84A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 GLY A 288
ASP A 142
LEU A 252
VAL A 349
LEU A 216
None
1.21A 1r30A-5j84A:
undetectable
1r30A-5j84A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.10A 1utdT-5j84A:
undetectable
1utdU-5j84A:
undetectable
1utdT-5j84A:
8.03
1utdU-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 GLY A 151
GLY A 150
GLY A 126
ASP A 230
PHE A 323
None
1.17A 1wg8B-5j84A:
3.6
1wg8B-5j84A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 ASN A  60
GLY A 151
THR A  52
LEU A 124
THR A 149
None
1.01A 2egvA-5j84A:
undetectable
2egvA-5j84A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 ASN A  60
GLY A 151
THR A  52
LEU A 124
THR A 149
None
1.04A 2egvB-5j84A:
2.7
2egvB-5j84A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 GLY A 204
GLY A 275
ILE A 267
ASN A 278
LEU A 284
None
None
None
KCX  A 129 ( 3.9A)
None
0.96A 2nxeB-5j84A:
undetectable
2nxeB-5j84A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 6 ARG A 386
THR A 491
ALA A 394
PRO A 500
None
1.39A 2ql8A-5j84A:
undetectable
2ql8B-5j84A:
undetectable
2ql8A-5j84A:
14.43
2ql8B-5j84A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 7 ILE A 369
LEU A 336
LEU A 329
GLY A 328
None
0.97A 2qqcD-5j84A:
undetectable
2qqcE-5j84A:
undetectable
2qqcD-5j84A:
13.60
2qqcE-5j84A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 8 ILE A 369
LEU A 336
LEU A 329
GLY A 328
None
0.88A 2qqdB-5j84A:
undetectable
2qqdC-5j84A:
undetectable
2qqdB-5j84A:
14.15
2qqdC-5j84A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 GLY A 204
GLY A 275
ILE A 267
ASN A 278
LEU A 284
None
None
None
KCX  A 129 ( 3.9A)
None
0.88A 2zbpA-5j84A:
undetectable
2zbpA-5j84A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
3 / 3 THR A 202
SER A 276
LYS A 397
None
1.09A 3aocC-5j84A:
undetectable
3aocC-5j84A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 241
GLN A 238
ILE A  49
VAL A 122
VAL A 148
None
1.31A 3fhjB-5j84A:
undetectable
3fhjB-5j84A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 8 ASN A 278
LEU A 284
ALA A 557
HIS A 490
KCX  A 129 ( 3.9A)
None
None
None
0.96A 3kp6A-5j84A:
undetectable
3kp6A-5j84A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 ARG A 289
LEU A 566
ALA A 106
GLY A 137
LEU A  50
None
1.00A 3ku1G-5j84A:
2.0
3ku1G-5j84A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
3 / 3 ASP A 142
ASN A 572
SER A 255
None
0.99A 3lsfB-5j84A:
1.0
3lsfE-5j84A:
undetectable
3lsfB-5j84A:
18.38
3lsfE-5j84A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 VAL A 488
LEU A 296
GLY A 393
ALA A 390
LEU A 519
None
1.06A 3n8zB-5j84A:
undetectable
3n8zB-5j84A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 LEU A 333
ALA A 272
GLY A 303
ILE A 267
LEU A 336
None
0.88A 3ogpA-5j84A:
undetectable
3ogpA-5j84A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 LEU A 333
ALA A 272
GLY A 303
ILE A 267
LEU A 336
None
1.00A 3ogqA-5j84A:
undetectable
3ogqA-5j84A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 SER A 276
GLY A 481
THR A 482
SER A 207
THR A 208
None
1.50A 3r75A-5j84A:
4.4
3r75A-5j84A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 SER A 276
GLY A 481
THR A 482
SER A 207
THR A 208
None
1.50A 3r75B-5j84A:
undetectable
3r75B-5j84A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 5 ALA A 210
GLU A 214
ALA A 225
MET A 236
None
1.18A 3r9tC-5j84A:
3.5
3r9tC-5j84A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 9 LEU A 333
ALA A 272
GLY A 303
ILE A 267
LEU A 342
None
0.95A 3u7sA-5j84A:
undetectable
3u7sA-5j84A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 SER A 350
SER A 221
LEU A 333
VAL A 358
ALA A 346
None
1.46A 3u9fD-5j84A:
undetectable
3u9fE-5j84A:
undetectable
3u9fD-5j84A:
16.43
3u9fE-5j84A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 SER A 350
SER A 221
LEU A 333
VAL A 358
ALA A 346
None
1.36A 3u9fG-5j84A:
undetectable
3u9fH-5j84A:
undetectable
3u9fG-5j84A:
16.43
3u9fH-5j84A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 9 ALA A 400
GLY A 485
LEU A 406
LEU A 396
ASN A 456
None
1.16A 3wdmC-5j84A:
undetectable
3wdmC-5j84A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 11 ILE A 281
ALA A 557
GLY A 556
GLU A 555
GLY A 447
None
1.30A 4e47A-5j84A:
undetectable
4e47A-5j84A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 11 ILE A 281
ALA A 557
GLY A 556
GLU A 555
GLY A 447
None
1.29A 4e47C-5j84A:
undetectable
4e47C-5j84A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 GLY A 274
GLY A 380
THR A 308
LEU A 376
ASN A 311
None
1.18A 4f84A-5j84A:
undetectable
4f84A-5j84A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 11 ILE A 281
ALA A 557
GLY A 556
GLU A 555
GLY A 447
None
1.29A 4jdsB-5j84A:
undetectable
4jdsB-5j84A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 11 ILE A 281
ALA A 557
GLY A 556
GLU A 555
GLY A 447
None
1.26A 4jdsC-5j84A:
undetectable
4jdsC-5j84A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 ILE A 281
ALA A 557
GLY A 556
GLU A 555
GLY A 447
None
1.28A 4jlgA-5j84A:
undetectable
4jlgA-5j84A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
3 / 3 LYS A 253
PRO A 254
SER A 255
None
0.31A 4k50I-5j84A:
0.9
4k50I-5j84A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 7 THR A 240
HIS A  62
LEU A  63
ASN A  51
None
1.14A 4pfjA-5j84A:
3.8
4pfjA-5j84A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 ILE A 510
GLY A 410
ASN A 435
ARG A 411
ILE A 474
None
1.09A 4rvgA-5j84A:
undetectable
4rvgA-5j84A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 4 ALA A 219
VAL A 148
GLY A 126
THR A 131
None
1.02A 4ubeA-5j84A:
3.1
4ubeA-5j84A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 LEU A 134
THR A 131
THR A 130
VAL A  86
PRO A  85
None
None
KCX  A 129 ( 3.9A)
None
None
0.93A 4xiwB-5j84A:
undetectable
4xiwE-5j84A:
undetectable
4xiwB-5j84A:
18.29
4xiwE-5j84A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
3 / 3 ARG A 232
ASP A 230
TYR A 325
None
0.83A 4yo9B-5j84A:
undetectable
4yo9B-5j84A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 11 ILE A 281
ALA A 557
GLY A 556
GLU A 555
GLY A 447
None
1.29A 5ayfA-5j84A:
undetectable
5ayfA-5j84A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.10A 5eeuF-5j84A:
undetectable
5eeuG-5j84A:
undetectable
5eeuF-5j84A:
8.03
5eeuG-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.14A 5eeuI-5j84A:
undetectable
5eeuJ-5j84A:
undetectable
5eeuI-5j84A:
8.03
5eeuJ-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.09A 5eeuO-5j84A:
undetectable
5eeuP-5j84A:
undetectable
5eeuO-5j84A:
8.03
5eeuP-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.12A 5eeuQ-5j84A:
undetectable
5eeuR-5j84A:
undetectable
5eeuQ-5j84A:
8.03
5eeuR-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.10A 5eevF-5j84A:
undetectable
5eevG-5j84A:
undetectable
5eevF-5j84A:
8.03
5eevG-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.14A 5eevI-5j84A:
undetectable
5eevJ-5j84A:
undetectable
5eevI-5j84A:
8.03
5eevJ-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 8 GLY A 274
ALA A 400
THR A 377
THR A 308
None
0.77A 5eevL-5j84A:
undetectable
5eevV-5j84A:
undetectable
5eevL-5j84A:
8.03
5eevV-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.10A 5eevO-5j84A:
undetectable
5eevP-5j84A:
undetectable
5eevO-5j84A:
8.03
5eevP-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.12A 5eevQ-5j84A:
undetectable
5eevR-5j84A:
undetectable
5eevQ-5j84A:
8.03
5eevR-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.10A 5eewF-5j84A:
undetectable
5eewG-5j84A:
undetectable
5eewF-5j84A:
8.03
5eewG-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.14A 5eewI-5j84A:
undetectable
5eewJ-5j84A:
undetectable
5eewI-5j84A:
8.03
5eewJ-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 8 GLY A 274
ALA A 400
THR A 377
THR A 308
None
0.78A 5eewL-5j84A:
undetectable
5eewV-5j84A:
undetectable
5eewL-5j84A:
8.03
5eewV-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.10A 5eewO-5j84A:
undetectable
5eewP-5j84A:
undetectable
5eewO-5j84A:
8.03
5eewP-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.12A 5eewQ-5j84A:
undetectable
5eewR-5j84A:
undetectable
5eewQ-5j84A:
8.03
5eewR-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.10A 5eexF-5j84A:
undetectable
5eexG-5j84A:
undetectable
5eexF-5j84A:
8.03
5eexG-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.09A 5eexO-5j84A:
undetectable
5eexP-5j84A:
undetectable
5eexO-5j84A:
8.03
5eexP-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.10A 5eeyF-5j84A:
undetectable
5eeyG-5j84A:
undetectable
5eeyF-5j84A:
8.03
5eeyG-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.09A 5eeyO-5j84A:
undetectable
5eeyP-5j84A:
undetectable
5eeyO-5j84A:
8.03
5eeyP-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.10A 5eezF-5j84A:
undetectable
5eezG-5j84A:
undetectable
5eezF-5j84A:
8.03
5eezG-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 8 GLY A 274
ALA A 400
THR A 377
THR A 308
None
0.77A 5eezL-5j84A:
undetectable
5eezV-5j84A:
undetectable
5eezL-5j84A:
8.03
5eezV-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.09A 5eezO-5j84A:
undetectable
5eezP-5j84A:
undetectable
5eezO-5j84A:
8.03
5eezP-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.10A 5ef0F-5j84A:
undetectable
5ef0G-5j84A:
undetectable
5ef0F-5j84A:
8.03
5ef0G-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.09A 5ef0O-5j84A:
undetectable
5ef0P-5j84A:
undetectable
5ef0O-5j84A:
8.03
5ef0P-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.09A 5ef1F-5j84A:
undetectable
5ef1G-5j84A:
undetectable
5ef1F-5j84A:
8.03
5ef1G-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 8 GLY A 274
ALA A 400
THR A 377
THR A 308
None
0.78A 5ef1L-5j84A:
undetectable
5ef1V-5j84A:
undetectable
5ef1L-5j84A:
8.03
5ef1V-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.10A 5ef1O-5j84A:
undetectable
5ef1P-5j84A:
undetectable
5ef1O-5j84A:
8.03
5ef1P-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.09A 5ef2F-5j84A:
undetectable
5ef2G-5j84A:
undetectable
5ef2F-5j84A:
8.03
5ef2G-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 8 GLY A 274
ALA A 400
THR A 377
THR A 308
None
0.77A 5ef2L-5j84A:
undetectable
5ef2V-5j84A:
undetectable
5ef2L-5j84A:
8.03
5ef2V-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.10A 5ef2O-5j84A:
undetectable
5ef2P-5j84A:
undetectable
5ef2O-5j84A:
8.03
5ef2P-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 THR A 377
SER A 315
ALA A 400
GLY A 381
ILE A 382
None
1.09A 5ef3F-5j84A:
undetectable
5ef3G-5j84A:
undetectable
5ef3F-5j84A:
8.03
5ef3G-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 8 GLY A 274
ALA A 400
THR A 377
THR A 308
None
0.78A 5ef3L-5j84A:
undetectable
5ef3V-5j84A:
undetectable
5ef3L-5j84A:
8.03
5ef3V-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 GLY A 381
ILE A 382
THR A 377
SER A 315
ALA A 400
None
1.09A 5ef3O-5j84A:
undetectable
5ef3P-5j84A:
undetectable
5ef3O-5j84A:
8.03
5ef3P-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 7 LEU A  40
PHE A  80
SER A  13
ILE A 244
None
1.00A 5n5dA-5j84A:
2.4
5n5dA-5j84A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
3 / 3 HIS A 282
SER A 133
LYS A 130
KCX  A 129 ( 4.1A)
KCX  A 129 ( 2.8A)
KCX  A 129 ( 3.1A)
1.33A 5os7A-5j84A:
undetectable
5os7A-5j84A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 ALA A 452
GLY A 444
GLU A 494
GLY A 447
LEU A 563
None
1.10A 5ul4A-5j84A:
5.5
5ul4A-5j84A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
4 / 7 LEU A 329
ALA A 224
THR A 149
THR A 131
None
0.85A 6a7jA-5j84A:
undetectable
6a7jA-5j84A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 ASN A 456
HIS A 490
ALA A 483
GLY A 481
ILE A 382
None
0.86A 6bniA-5j84A:
undetectable
6bniA-5j84A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 10 ASN A 456
HIS A 490
ALA A 483
GLY A 481
ILE A 382
None
0.84A 6bniB-5j84A:
undetectable
6bniB-5j84A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
5 / 12 LEU A 336
ASP A 356
VAL A 358
GLY A 217
VAL A 332
None
1.09A 6dgxB-5j84A:
undetectable
6dgxB-5j84A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum)
3 / 3 HIS A 282
SER A 133
LYS A 130
KCX  A 129 ( 4.1A)
KCX  A 129 ( 2.8A)
KCX  A 129 ( 3.1A)
1.33A 6gmdB-5j84A:
undetectable
6gmdB-5j84A:
21.17