SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 536
VAL A 505
ILE A 538
GLY A 541
ILE A 593
 None
 0.95A 1c6zB-5j8jA:
undetectable		 1c6zB-5j8jA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 511
SER A 510
ASN A 533
GLY A 594
 None
 0.79A 1me7A-5j8jA:
undetectable		 1me7A-5j8jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		4 / 7 SER A 646
VAL A 603
TYR A 599
ILE A 648
 None
 0.61A 2x45B-5j8jA:
undetectable		 2x45B-5j8jA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		4 / 7 SER A 646
VAL A 603
TYR A 599
ILE A 648
 None
 0.62A 2x45C-5j8jA:
undetectable		 2x45C-5j8jA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 469
PHE A 537
GLY A 541
ILE A 695
PHE A 621
 None
 1.20A 2zznA-5j8jA:
undetectable		 2zznA-5j8jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 469
PHE A 537
GLY A 541
ILE A 695
PHE A 621
 None
 1.21A 2zznB-5j8jA:
undetectable		 2zznB-5j8jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		4 / 7 SER A 646
VAL A 603
TYR A 599
ILE A 648
 None
 0.81A 3bu1A-5j8jA:
undetectable		 3bu1A-5j8jA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 590
ILE A 496
SER A 497
LEU A 576
ILE A 504
 None
 1.04A 3cd2A-5j8jA:
undetectable		 3cd2A-5j8jA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 488
ASP A 550
SER A 534
HIS A 507
 None
 0.95A 3sg9B-5j8jA:
undetectable		 3sg9B-5j8jA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 565
SER A 564
SER A 598
ASP A 597
VAL A 551
 None
 1.09A 3v8vA-5j8jA:
2.1		 3v8vA-5j8jA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 550
ASP A 532
HIS A 507
SER A 534
 None
 1.18A 4k7gB-5j8jA:
0.7		 4k7gB-5j8jA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 507
LEU A 491
LEU A 469
ASP A 532
SER A 534
 None
 1.28A 4r88A-5j8jA:
undetectable		 4r88A-5j8jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 507
LEU A 491
LEU A 469
ASP A 532
SER A 534
 None
 1.30A 4r88B-5j8jA:
undetectable		 4r88B-5j8jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 507
LEU A 491
LEU A 469
ASP A 532
SER A 534
 None
 1.25A 4r88C-5j8jA:
undetectable		 4r88C-5j8jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 507
LEU A 491
LEU A 469
ASP A 532
SER A 534
 None
 1.28A 4r88D-5j8jA:
undetectable		 4r88D-5j8jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 507
LEU A 491
LEU A 469
ASP A 532
SER A 534
 None
 1.27A 4r88E-5j8jA:
undetectable		 4r88E-5j8jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 507
LEU A 491
LEU A 469
ASP A 532
SER A 534
 None
 1.25A 4r88F-5j8jA:
undetectable		 4r88F-5j8jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 606
TYR A 599
SER A 646
 None
 0.88A 5iktA-5j8jA:
undetectable		 5iktA-5j8jA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 679
ASP A 624
GLY A 596
ILE A 595
 None
 0.64A 5kr1B-5j8jA:
undetectable		 5kr1B-5j8jA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 532
ASP A 597
ASN A 620
ASN A 533
 None
 1.27A 5l6eA-5j8jA:
undetectable		 5l6eA-5j8jA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5j8j HISTONE DEACETYLASE
HDA1
(Saccharomyces
cerevisiae) 		5 / 12 SER A 569
THR A 568
ILE A 567
LEU A 680
LEU A 622
 None
 1.34A 6a93A-5j8jA:
undetectable		 6a93A-5j8jA:
22.55