SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j8n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5j8n EXODEOXYRIBONUCLEASE
III
(Methanosarcina
mazei) 		4 / 5 TYR A 241
SER A 237
SER A 239
ASN A   6
 None
 1.36A 1yvpA-5j8nA:
undetectable		 1yvpA-5j8nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5j8n EXODEOXYRIBONUCLEASE
III
(Methanosarcina
mazei) 		4 / 6 SER A 239
ALA A 238
SER A 237
ASN A   6
 None
 0.98A 1yvpB-5j8nA:
undetectable		 1yvpB-5j8nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5j8n EXODEOXYRIBONUCLEASE
III
(Methanosarcina
mazei) 		4 / 7 SER A 239
ALA A 238
SER A 237
ASN A   6
 None
 1.05A 2i91A-5j8nA:
undetectable		 2i91A-5j8nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5j8n EXODEOXYRIBONUCLEASE
III
(Methanosarcina
mazei) 		4 / 7 SER A 239
ALA A 238
SER A 237
ASN A   6
 None
 1.05A 2i91B-5j8nA:
undetectable		 2i91B-5j8nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 5j8n EXODEOXYRIBONUCLEASE
III
(Methanosarcina
mazei) 		5 / 12 LEU A 108
ASN A 110
LEU A 109
VAL A 227
LEU A 254
 None
 1.31A 2q7kA-5j8nA:
undetectable		 2q7kA-5j8nA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 5j8n EXODEOXYRIBONUCLEASE
III
(Methanosarcina
mazei) 		5 / 12 GLY A 253
ALA A 238
ARG A  31
ILE A   8
ILE A 244
 None
 1.00A 4uw0A-5j8nA:
undetectable		 4uw0A-5j8nA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5j8n EXODEOXYRIBONUCLEASE
III
(Methanosarcina
mazei) 		4 / 7 LEU A 147
LEU A 109
LYS A 141
LEU A 140
 None
 0.82A 4wg0L-5j8nA:
undetectable
4wg0M-5j8nA:
undetectable		 4wg0L-5j8nA:
5.24
4wg0M-5j8nA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5j8n EXODEOXYRIBONUCLEASE
III
(Methanosarcina
mazei) 		4 / 7 GLN A  38
GLY A  73
ILE A  34
TYR A  57
 None
 1.12A 5vlmC-5j8nA:
undetectable		 5vlmC-5j8nA:
20.30