SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		4 / 7 HIS A 121
LEU A  96
THR A  93
THR A  92
 PLP  A 501 ( 3.5A)
None
PLP  A 501 (-3.5A)
PLP  A 501 (-3.9A)
 0.89A 1am6A-5j8qA:
undetectable		 1am6A-5j8qA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		4 / 7 HIS A 121
LEU A  96
THR A  93
THR A  92
 PLP  A 501 ( 3.5A)
None
PLP  A 501 (-3.5A)
PLP  A 501 (-3.9A)
 1.05A 1am6A-5j8qA:
undetectable		 1am6A-5j8qA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 11 ARG A  75
ILE A  86
ILE A  87
GLY A  69
PHE A  88
 None
 1.07A 2azyA-5j8qA:
undetectable		 2azyA-5j8qA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 12 ILE A 187
ALA A 188
ALA A 193
THR A 163
VAL A 159
 None
 1.00A 2fr3A-5j8qA:
undetectable		 2fr3A-5j8qA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		4 / 5 TRP A 128
ALA A 131
LEU A  96
ALA A 104
 None
 1.21A 2jstA-5j8qA:
undetectable
2jstB-5j8qA:
undetectable		 2jstA-5j8qA:
9.75
2jstB-5j8qA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		4 / 6 ILE A 299
SER A 300
ILE A 208
PHE A  77
 None
 1.12A 2q72A-5j8qA:
undetectable		 2q72A-5j8qA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 9 THR A 346
VAL A 347
LEU A 348
ALA A 375
ALA A 357
 None
 1.10A 3ax7B-5j8qA:
undetectable		 3ax7B-5j8qA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		4 / 6 ALA A 193
SER A 161
THR A 163
VAL A 166
 None
 1.05A 3d2tB-5j8qA:
undetectable		 3d2tB-5j8qA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 12 GLY A 199
HIS A 223
LEU A 284
VAL A  74
ILE A  78
 None
PLP  A 501 (-3.9A)
None
None
None
 1.11A 3g9eA-5j8qA:
undetectable		 3g9eA-5j8qA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		3 / 3 ALA A 219
VAL A 196
TRP A 128
 None
 0.85A 3l8lC-5j8qA:
undetectable
3l8lD-5j8qA:
undetectable		 3l8lC-5j8qA:
3.38
3l8lD-5j8qA:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 10 ILE A   3
ILE A   6
MET A   1
TYR A 380
ILE A 299
 None
 0.99A 3p4wD-5j8qA:
undetectable		 3p4wD-5j8qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 10 ILE A   3
ILE A   6
MET A   1
TYR A 380
ILE A 299
 None
 0.98A 3p4wE-5j8qA:
undetectable		 3p4wE-5j8qA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		6 / 8 ALA A  29
HIS A 121
ASN A 173
LYS A 224
ARG A 356
ARG A 376
 ALA  A 502 (-3.6A)
PLP  A 501 ( 3.5A)
ALA  A 502 ( 3.9A)
PLP  A 501 (-1.2A)
None
ALA  A 502 (-2.8A)
 0.41A 5db5A-5j8qA:
59.5
5db5B-5j8qA:
59.7		 5db5A-5j8qA:
47.27
5db5B-5j8qA:
47.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 12 LEU A 220
SER A 221
ILE A 208
VAL A 197
VAL A 210
 None
PLP  A 501 (-2.5A)
None
None
None
 1.03A 5dpdA-5j8qA:
undetectable		 5dpdA-5j8qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 12 LEU A 220
SER A 221
ILE A 208
VAL A 197
VAL A 210
 None
PLP  A 501 (-2.5A)
None
None
None
 1.11A 5dpdB-5j8qA:
undetectable		 5dpdB-5j8qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		4 / 7 ILE A   3
ILE A   6
MET A   1
ILE A 299
 None
 0.91A 5murB-5j8qA:
undetectable		 5murB-5j8qA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 10 ILE A   3
ILE A   6
MET A   1
TYR A 380
ILE A 299
 None
 1.04A 5mzrA-5j8qA:
undetectable		 5mzrA-5j8qA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 10 ILE A   3
ILE A   6
MET A   1
TYR A 380
ILE A 299
 None
 1.03A 5mzrC-5j8qA:
undetectable		 5mzrC-5j8qA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 9 ILE A   3
ILE A   6
MET A   1
TYR A 380
ILE A 299
 None
 1.06A 5mzrD-5j8qA:
undetectable		 5mzrD-5j8qA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		3 / 3 HIS A 223
SER A  31
LYS A  33
 PLP  A 501 (-3.9A)
None
None
 1.06A 5os7A-5j8qA:
undetectable		 5os7A-5j8qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		5 / 11 VAL A 171
SER A 169
VAL A 332
LEU A 331
ALA A 200
 None
None
None
None
PLP  A 501 (-3.5A)
 1.30A 6dryA-5j8qA:
undetectable		 6dryA-5j8qA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5j8q CYSTEINE DESULFURASE
SUFS
(Bacillus
subtilis) 		3 / 3 HIS A 223
SER A  31
LYS A  33
 PLP  A 501 (-3.9A)
None
None
 1.06A 6gmdB-5j8qA:
undetectable		 6gmdB-5j8qA:
21.60