SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j9g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 7 SER A 155
THR A 157
ASN A 159
TYR A 318
ASN A 320
 None
 0.32A 1dssG-5j9gA:
46.5		 1dssG-5j9gA:
45.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		6 / 8 SER A 155
THR A 157
ASN A 159
HIS A 183
TYR A 318
ASN A 320
 None
 0.49A 1dssR-5j9gA:
46.1		 1dssR-5j9gA:
45.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 12 PHE A  18
GLY A   9
PHE A  10
TYR A 105
ALA A  84
 None
 1.20A 1hvyA-5j9gA:
undetectable		 1hvyA-5j9gA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 12 PHE A  18
ILE A  36
PHE A  10
TYR A 105
ALA A  84
 None
 1.24A 1hvyA-5j9gA:
undetectable		 1hvyA-5j9gA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 10 LEU A  49
ILE A  69
VAL A  33
LEU A  99
PHE A  10
 None
 1.04A 1xp0A-5j9gA:
undetectable		 1xp0A-5j9gA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		3 / 3 SER A 138
ARG A 330
GLN A 327
 None
 1.01A 2xnrA-5j9gA:
1.9		 2xnrA-5j9gA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APT_B_ACTB311_0
(METHYLENETETRAHYDROF
OLATE REDUCTASE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 9 GLU A 321
HIS A  55
LEU A  16
ASP A  52
ILE A  13
 None
 1.40A 3aptB-5j9gA:
undetectable		 3aptB-5j9gA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		6 / 8 SER A 155
THR A 157
ASN A 159
HIS A 183
TYR A 318
ASN A 320
 None
 0.40A 3dmtC-5j9gA:
45.2		 3dmtC-5j9gA:
41.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 12 TYR A 318
ASN A 230
GLY A 217
ALA A 218
GLY A 223
 None
 0.87A 3hs6B-5j9gA:
undetectable		 3hs6B-5j9gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		3 / 3 ASP A  93
ARG A  77
ALA A  35
 None
 0.61A 3mbgC-5j9gA:
undetectable		 3mbgC-5j9gA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		4 / 6 VAL A  78
VAL A  95
ILE A  87
ARG A  15
 None
 1.08A 3ms9A-5j9gA:
undetectable		 3ms9A-5j9gA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		4 / 6 VAL A  78
VAL A  95
ILE A  87
ARG A  15
 None
 1.09A 3mssA-5j9gA:
undetectable		 3mssA-5j9gA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		4 / 6 VAL A  78
VAL A  95
ILE A  87
ARG A  15
 None
 1.10A 3mssC-5j9gA:
undetectable		 3mssC-5j9gA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 12 TYR A 318
ASN A 230
GLY A 217
ALA A 218
GLY A 223
 None
 0.84A 4e1gA-5j9gA:
undetectable		 4e1gA-5j9gA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 12 THR A 248
THR A 134
VAL A 225
ILE A 222
GLU A 228
 None
 1.34A 4i41A-5j9gA:
2.5		 4i41A-5j9gA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		4 / 8 ILE A  21
PHE A  10
TYR A  76
LEU A  49
 None
 0.86A 4qopC-5j9gA:
undetectable		 4qopC-5j9gA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 11 SER A 155
LEU A 161
PRO A 163
VAL A 136
THR A 134
 None
 1.20A 4uuuB-5j9gA:
undetectable		 4uuuB-5j9gA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		4 / 7 THR A 157
LEU A 161
THR A 216
THR A 248
 None
 0.89A 4z91F-5j9gA:
undetectable
4z91G-5j9gA:
undetectable
4z91H-5j9gA:
undetectable
4z91I-5j9gA:
undetectable
4z91J-5j9gA:
undetectable		 4z91F-5j9gA:
21.29
4z91G-5j9gA:
21.29
4z91H-5j9gA:
21.29
4z91I-5j9gA:
21.29
4z91J-5j9gA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		4 / 7 THR A 248
THR A 157
LEU A 161
THR A 216
 None
 0.95A 4z91F-5j9gA:
undetectable
4z91G-5j9gA:
undetectable
4z91H-5j9gA:
undetectable
4z91I-5j9gA:
undetectable
4z91J-5j9gA:
undetectable		 4z91F-5j9gA:
21.29
4z91G-5j9gA:
21.29
4z91H-5j9gA:
21.29
4z91I-5j9gA:
21.29
4z91J-5j9gA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 12 LEU A 168
ILE A 222
GLY A 177
PHE A 296
THR A 259
 None
 1.17A 5eskA-5j9gA:
undetectable		 5eskA-5j9gA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 12 ALA A  46
HIS A  47
LEU A  49
PHE A  58
THR A  57
 None
 0.75A 5k9dA-5j9gA:
undetectable		 5k9dA-5j9gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		5 / 12 ALA A  17
GLY A   6
GLU A  32
ALA A  35
TYR A  79
 None
 1.09A 5n5dA-5j9gA:
4.3		 5n5dA-5j9gA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		4 / 6 GLN A  83
HIS A 114
ALA A  84
GLN A  85
 None
 1.49A 6f6jC-5j9gA:
undetectable
6f6jD-5j9gA:
undetectable		 6f6jC-5j9gA:
21.43
6f6jD-5j9gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		3 / 3 ASN A 264
PRO A 298
GLN A 300
 None
 0.77A 6jnhA-5j9gA:
undetectable		 6jnhA-5j9gA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE
(Lactobacillus
acidophilus) 		3 / 3 ASN A 264
PRO A 298
GLN A 300
 None
 0.78A 6jogA-5j9gA:
3.1		 6jogA-5j9gA:
20.41