SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j9h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5j9h ENVELOPMENT
POLYPROTEIN
(Puumala
orthohantavirus) 		4 / 6 SER A 799
VAL A 800
GLY A 801
LEU A 857
 None
 0.78A 1fduD-5j9hA:
undetectable		 1fduD-5j9hA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5j9h ENVELOPMENT
POLYPROTEIN
(Puumala
orthohantavirus) 		4 / 6 SER A 838
THR A 836
LEU A 974
ASP A 973
 None
 1.30A 1mxdA-5j9hA:
undetectable		 1mxdA-5j9hA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5j9h ENVELOPMENT
POLYPROTEIN
(Puumala
orthohantavirus) 		5 / 12 ILE A 943
VAL A 938
PHE A 936
ILE A 722
PHE A 804
 None
 1.14A 1xozA-5j9hA:
undetectable		 1xozA-5j9hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5j9h ENVELOPMENT
POLYPROTEIN
(Puumala
orthohantavirus) 		4 / 4 LEU A1006
THR A1007
ILE A1016
HIS A1056
 None
 1.07A 2jfaB-5j9hA:
undetectable		 2jfaB-5j9hA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 5j9h ENVELOPMENT
POLYPROTEIN
(Puumala
orthohantavirus) 		4 / 8 ILE A 726
LEU A 948
PHE A 858
GLY A 866
 None
None
None
NAG  A1202 (-4.0A)
 1.01A 3selX-5j9hA:
undetectable		 3selX-5j9hA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5j9h ENVELOPMENT
POLYPROTEIN
(Puumala
orthohantavirus) 		5 / 11 LEU A 856
THR A 855
GLU A 725
ALA A 724
HIS A 728
 None
 1.20A 4e0fA-5j9hA:
undetectable		 4e0fA-5j9hA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5j9h ENVELOPMENT
POLYPROTEIN
(Puumala
orthohantavirus) 		5 / 10 THR A 771
THR A 788
ALA A 789
ALA A 742
GLY A 747
 None
 0.93A 4qvyK-5j9hA:
undetectable
4qvyL-5j9hA:
undetectable		 4qvyK-5j9hA:
18.97
4qvyL-5j9hA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5j9h ENVELOPMENT
POLYPROTEIN
(Puumala
orthohantavirus) 		5 / 10 THR A 771
THR A 788
ALA A 789
ALA A 742
GLY A 747
 None
 0.92A 4qvyY-5j9hA:
undetectable
4qvyZ-5j9hA:
undetectable		 4qvyY-5j9hA:
18.97
4qvyZ-5j9hA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5j9h ENVELOPMENT
POLYPROTEIN
(Puumala
orthohantavirus) 		4 / 7 ALA A 986
THR A 985
ALA A 984
THR A1038
 None
 1.03A 4qw0K-5j9hA:
undetectable		 4qw0K-5j9hA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5j9h ENVELOPMENT
POLYPROTEIN
(Puumala
orthohantavirus) 		4 / 7 ALA A 986
THR A 985
ALA A 984
THR A1038
 None
 1.02A 4qw0Y-5j9hA:
undetectable		 4qw0Y-5j9hA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5j9h ENVELOPMENT
POLYPROTEIN
(Puumala
orthohantavirus) 		5 / 12 ILE A 763
GLY A 791
THR A 741
PHE A 915
LEU A 739
 None
 1.18A 5fhzA-5j9hA:
undetectable		 5fhzA-5j9hA:
21.15