SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5j9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
4 / 8 LEU A 106
ARG A  34
GLY A  35
TYR A 104
None
0.90A 1fapB-5j9rA:
undetectable
1fapB-5j9rA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
5 / 11 ILE A 126
LEU A  96
TYR A 156
ILE A 163
PHE A 124
None
1.12A 2dg9A-5j9rA:
undetectable
2dg9A-5j9rA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
4 / 7 LEU A 197
ILE A 234
ARG A 257
SER A  18
None
1.23A 2hc4A-5j9rA:
undetectable
2hc4A-5j9rA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
3 / 3 GLU A  71
GLN A 103
ARG A  38
None
0.99A 2w3bB-5j9rA:
undetectable
2w3bB-5j9rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
5 / 12 SER A 211
PHE A 207
THR A   2
THR A 173
VAL A 259
None
1.21A 2zifA-5j9rA:
undetectable
2zifA-5j9rA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
5 / 11 TYR A 104
PRO A 123
TYR A  86
ILE A 126
PRO A  94
None
1.14A 3ganA-5j9rA:
undetectable
3ganA-5j9rA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
5 / 11 VAL A 118
PRO A 123
TYR A  86
ILE A 126
PRO A  94
None
1.21A 3ganA-5j9rA:
undetectable
3ganA-5j9rA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
3 / 3 MET A  69
MET A  19
PHE A 268
None
1.35A 3gn8A-5j9rA:
undetectable
3gn8A-5j9rA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
4 / 4 GLY A  54
GLU A  71
ASP A 286
ASP A 107
None
1.42A 3mb5A-5j9rA:
undetectable
3mb5A-5j9rA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
4 / 8 PHE A 124
PHE A 323
ALA A 102
THR A  65
None
1.11A 3t3sE-5j9rA:
undetectable
3t3sE-5j9rA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
5 / 12 GLY A 149
ARG A   3
LEU A 142
VAL A 112
ALA A 115
None
1.13A 3t7vA-5j9rA:
undetectable
3t7vA-5j9rA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
3 / 3 MET A 196
ASP A 205
PHE A 207
None
1.06A 4xeyA-5j9rA:
undetectable
4xeyA-5j9rA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens)
5 / 12 LEU A 184
PRO A 176
THR A 177
GLU A 155
HIS A 164
None
1.23A 5xipC-5j9rA:
undetectable
5xipC-5j9rA:
20.59