SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ja9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 5ja9 NANOBODY 6
(Lama
glama) 		3 / 3 ASP A 106
GLU A   7
ARG A  73
 None
 0.82A 1wopA-5ja9A:
1.9		 1wopA-5ja9A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5ja9 NANOBODY 6
(Lama
glama) 		6 / 11 PHE A  30
ASN A  75
GLY A  56
THR A  59
ILE A  71
LEU A  80
 None
 1.39A 1z11A-5ja9A:
undetectable		 1z11A-5ja9A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5ja9 NANOBODY 6
(Lama
glama) 		4 / 6 SER A  54
SER A  58
PHE A  51
ARG A  36
 None
None
EDO  A 202 (-3.0A)
EDO  A 202 ( 3.9A)
 1.42A 2c8aC-5ja9A:
undetectable		 2c8aC-5ja9A:
17.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5ja9 NANOBODY 6
(Lama
glama) 		5 / 12 ALA A  25
MET A  35
ARG A  73
ASN A  78
ALA A  99
 None
 1.01A 3qxtA-5ja9A:
20.4		 3qxtA-5ja9A:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5ja9 NANOBODY 6
(Lama
glama) 		6 / 12 VAL A   3
ALA A  25
MET A  35
ARG A  73
ASN A  75
ALA A  99
 None
 0.88A 3qxvA-5ja9A:
20.2		 3qxvA-5ja9A:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5ja9 NANOBODY 6
(Lama
glama) 		6 / 11 VAL A   3
ALA A  25
MET A  35
ARG A  73
ASN A  75
ALA A  99
 None
 0.89A 3qxvC-5ja9A:
20.4		 3qxvC-5ja9A:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5ja9 NANOBODY 6
(Lama
glama) 		5 / 12 VAL A   3
ALA A  25
MET A  35
ARG A  73
ALA A  99
 None
 0.93A 3qxvD-5ja9A:
20.2		 3qxvD-5ja9A:
68.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 5ja9 NANOBODY 6
TOXIN HIGB-2
(Lama
glama;
Vibrio
cholerae) 		4 / 4 ILE C  81
ARG A  36
TYR C  18
GLU C  17
 None
EDO  A 202 ( 3.9A)
EDO  A 202 ( 3.6A)
EDO  A 202 (-3.6A)
 1.35A 4zzbD-5ja9C:
undetectable		 4zzbD-5ja9C:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ja9 TOXIN HIGB-2
(Vibrio
cholerae) 		4 / 4 LEU C  78
ARG C  15
ILE C  65
PHE C  27
 None
 1.21A 5kirB-5ja9C:
undetectable		 5kirB-5ja9C:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 5ja9 NANOBODY 6
(Lama
glama) 		4 / 8 TRP A 108
PHE A  48
TYR A  38
ARG A  36
 None
EDO  A 202 ( 4.3A)
None
EDO  A 202 ( 3.9A)
 1.04A 5oajD-5ja9A:
undetectable
5oajE-5ja9A:
undetectable		 5oajD-5ja9A:
19.22
5oajE-5ja9A:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 5ja9 NANOBODY 6
(Lama
glama) 		3 / 3 TYR A  61
GLY A  67
THR A  70
 None
 0.20A 6cjkB-5ja9A:
19.2		 6cjkB-5ja9A:
30.97