SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jab'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5jab BILIVERDIN REDUCTASE
RV2074
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 100
TYR A 104
ILE A  50
VAL A 122
VAL A  40
GLY A  41
 None
None
None
None
6J4  A 201 (-4.2A)
6J4  A 201 (-3.9A)
 1.48A 2qe6A-5jabA:
undetectable		 2qe6A-5jabA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5jab BILIVERDIN REDUCTASE
RV2074
(Mycobacterium
tuberculosis) 		6 / 12 VAL A   4
LEU A  82
ILE A 124
LEU A  18
LEU A  15
ALA A  14
 None
 1.42A 4p65B-5jabA:
undetectable
4p65D-5jabA:
undetectable
4p65I-5jabA:
undetectable
4p65J-5jabA:
undetectable		 4p65B-5jabA:
13.64
4p65D-5jabA:
13.64
4p65I-5jabA:
14.86
4p65J-5jabA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5jab BILIVERDIN REDUCTASE
RV2074
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  82
VAL A   4
ILE A 124
LEU A  18
LEU A  15
ALA A  14
 None
 1.49A 4p65F-5jabA:
undetectable
4p65H-5jabA:
undetectable
4p65K-5jabA:
undetectable
4p65L-5jabA:
undetectable		 4p65F-5jabA:
13.64
4p65H-5jabA:
13.64
4p65K-5jabA:
14.86
4p65L-5jabA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jab BILIVERDIN REDUCTASE
RV2074
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 122
LEU A 134
MET A   1
 None
 0.86A 5ikrA-5jabA:
undetectable		 5ikrA-5jabA:
13.43