SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 8 SER A 183
HIS A 211
LYS A 242
ARG A 367
 None
 1.30A 1eqbA-5jayA:
28.5
1eqbB-5jayA:
28.5		 1eqbA-5jayA:
24.89
1eqbB-5jayA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 8 SER A 183
HIS A 211
LYS A 242
ARG A 367
 None
 1.30A 1eqbA-5jayA:
28.5
1eqbB-5jayA:
28.5		 1eqbA-5jayA:
24.89
1eqbB-5jayA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 8 SER A 183
HIS A 211
LYS A 242
ARG A 367
 None
 1.30A 1eqbC-5jayA:
28.5
1eqbD-5jayA:
28.5		 1eqbC-5jayA:
24.89
1eqbD-5jayA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 8 SER A 183
HIS A 211
LYS A 242
ARG A 367
 None
 1.30A 1eqbC-5jayA:
28.5
1eqbD-5jayA:
28.5		 1eqbC-5jayA:
24.89
1eqbD-5jayA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 4 LYS A 174
LEU A 166
ALA A 203
LEU A 197
 None
 1.39A 1f86B-5jayA:
undetectable		 1f86B-5jayA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A 340
THR A 343
ALA A 347
LEU A 312
LEU A 386
 None
 1.08A 1rjdA-5jayA:
3.4		 1rjdA-5jayA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A 340
THR A 343
ALA A 347
LEU A 312
LEU A 386
 None
 1.10A 1rjdB-5jayA:
undetectable		 1rjdB-5jayA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A 340
THR A 343
ALA A 347
LEU A 312
LEU A 386
 None
 1.09A 1rjdC-5jayA:
2.8		 1rjdC-5jayA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 6 ALA A 115
LEU A 117
ILE A 269
SER A 110
 None
 1.00A 1sbrA-5jayA:
undetectable
1sbrB-5jayA:
undetectable		 1sbrA-5jayA:
19.80
1sbrB-5jayA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 10 ALA A 223
ASP A 209
ILE A 289
LEU A  50
THR A 180
 None
 1.47A 1tdrB-5jayA:
undetectable		 1tdrB-5jayA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 7 GLY A  98
GLY A 290
PHE A 213
PHE A 250
 None
 0.80A 2qwxA-5jayA:
undetectable
2qwxB-5jayA:
undetectable		 2qwxA-5jayA:
20.20
2qwxB-5jayA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 7 GLY A 112
ALA A 115
MET A 114
SER A 139
 None
 0.93A 2wekB-5jayA:
5.1		 2wekB-5jayA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		3 / 3 ILE A 305
SER A 369
SER A 371
 None
 0.61A 3iltH-5jayA:
undetectable		 3iltH-5jayA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 4 LEU A 216
GLY A 222
GLY A 212
THR A 180
 None
 0.88A 3si7A-5jayA:
undetectable		 3si7A-5jayA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 11 LEU A 386
ALA A 384
LEU A 379
ARG A 307
GLY A 348
 None
 1.28A 3uudA-5jayA:
undetectable		 3uudA-5jayA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 11 PHE A 213
HIS A 211
GLY A 212
PHE A 250
GLY A 248
 None
 1.28A 3v3nA-5jayA:
undetectable		 3v3nA-5jayA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 11 PHE A 213
HIS A 211
GLY A 212
PHE A 250
GLY A 248
 None
 1.28A 3v3nD-5jayA:
undetectable		 3v3nD-5jayA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 VAL A 181
GLY A 212
VAL A 215
SER A 369
PRO A 328
 None
 1.48A 4bvaA-5jayA:
2.5		 4bvaA-5jayA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A  93
VAL A 246
ALA A 284
SER A 285
LEU A 286
 None
 1.20A 4m11A-5jayA:
undetectable		 4m11A-5jayA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 9 ALA A 249
GLY A 222
PHE A 213
SER A 236
GLY A 238
 None
 1.26A 4mmeB-5jayA:
undetectable		 4mmeB-5jayA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 4 VAL A 351
ALA A 353
ILE A 340
THR A 337
 None
 1.01A 5e4dB-5jayA:
1.3		 5e4dB-5jayA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 11 ILE A 289
GLY A 214
ASP A 209
ALA A 244
VAL A 282
 None
 1.35A 5hw4B-5jayA:
2.6		 5hw4B-5jayA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 5 GLY A 186
ARG A 309
ASP A 185
MET A 184
 None
 1.42A 5ubbA-5jayA:
undetectable		 5ubbA-5jayA:
18.66