SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 5jb3 TRANSLATION
INITIATION FACTOR 1A
(Pyrococcus
abyssi) 		5 / 10 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.26A 1fohA-5jb36:
undetectable		 1fohA-5jb36:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 5jb3 TRANSLATION
INITIATION FACTOR 1A
(Pyrococcus
abyssi) 		5 / 10 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.31A 1fohB-5jb36:
undetectable		 1fohB-5jb36:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 5jb3 TRANSLATION
INITIATION FACTOR 1A
(Pyrococcus
abyssi) 		5 / 10 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.33A 1fohC-5jb36:
undetectable		 1fohC-5jb36:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 5jb3 TRANSLATION
INITIATION FACTOR 1A
(Pyrococcus
abyssi) 		5 / 10 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.31A 1fohD-5jb36:
undetectable		 1fohD-5jb36:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 5jb3 30S RIBOSOMAL
PROTEIN S9
(Pyrococcus
abyssi) 		4 / 8 ILE K  45
LEU K  49
LYS K  23
GLY K  24
 None
None
G  21097 ( 3.7A)
None
 0.84A 1os6A-5jb3K:
undetectable		 1os6A-5jb3K:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 5jb3 30S RIBOSOMAL
PROTEIN S9
(Pyrococcus
abyssi) 		5 / 12 LEU K 107
GLY K  91
VAL K  87
ALA K  17
ILE K  62
 None
 0.99A 1pbkA-5jb3K:
undetectable		 1pbkA-5jb3K:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 5jb3 TRANSLATION
INITIATION FACTOR 1A
(Pyrococcus
abyssi) 		5 / 10 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.30A 1pn0A-5jb36:
undetectable		 1pn0A-5jb36:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 5jb3 TRANSLATION
INITIATION FACTOR 1A
(Pyrococcus
abyssi) 		5 / 10 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.30A 1pn0B-5jb36:
undetectable		 1pn0B-5jb36:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 5jb3 TRANSLATION
INITIATION FACTOR 1A
(Pyrococcus
abyssi) 		5 / 10 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.34A 1pn0C-5jb36:
undetectable		 1pn0C-5jb36:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 5jb3 TRANSLATION
INITIATION FACTOR 1A
(Pyrococcus
abyssi) 		5 / 10 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.34A 1pn0D-5jb36:
undetectable		 1pn0D-5jb36:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 5jb3 TRANSLATION
INITIATION FACTOR 1A
(Pyrococcus
abyssi) 		3 / 3 ASP 6  81
LYS 6  54
ARG 6  57
 None
G  2 471 ( 2.6A)
G  2 483 ( 2.8A)
 1.18A 1ra8A-5jb36:
undetectable		 1ra8A-5jb36:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5jb3 30S RIBOSOMAL
PROTEIN S3
(Pyrococcus
abyssi) 		3 / 3 ARG Z  63
ARG Z  67
ILE Z  80
 None
 0.82A 1uobA-5jb3Z:
undetectable		 1uobA-5jb3Z:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jb3 30S RIBOSOMAL
PROTEIN S2
(Pyrococcus
abyssi) 		4 / 6 ARG B  36
ILE B  19
GLY B  16
ALA B  15
 None
 0.93A 1wmqA-5jb3B:
undetectable		 1wmqA-5jb3B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jb3 30S RIBOSOMAL
PROTEIN S2
(Pyrococcus
abyssi) 		4 / 6 ARG B  36
ILE B  19
GLY B  16
ALA B  15
 None
 0.93A 1wmqB-5jb3B:
undetectable		 1wmqB-5jb3B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jb3 30S RIBOSOMAL
PROTEIN S2
(Pyrococcus
abyssi) 		4 / 6 ARG B  36
ILE B  19
GLY B  16
ALA B  15
 None
 0.91A 1wpuA-5jb3B:
undetectable		 1wpuA-5jb3B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jb3 30S RIBOSOMAL
PROTEIN S2
(Pyrococcus
abyssi) 		4 / 6 ARG B  36
ILE B  19
GLY B  16
ALA B  15
 None
 0.91A 1wpuB-5jb3B:
undetectable		 1wpuB-5jb3B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jb3 30S RIBOSOMAL
PROTEIN S2
(Pyrococcus
abyssi) 		4 / 6 ARG B  36
ILE B  19
GLY B  16
ALA B  15
 None
 0.94A 1wrqA-5jb3B:
undetectable		 1wrqA-5jb3B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jb3 30S RIBOSOMAL
PROTEIN S2
(Pyrococcus
abyssi) 		4 / 6 ARG B  36
ILE B  19
GLY B  16
ALA B  15
 None
 0.96A 1wrqB-5jb3B:
undetectable		 1wrqB-5jb3B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5jb3 30S RIBOSOMAL
PROTEIN S15
(Pyrococcus
abyssi) 		4 / 5 VAL Q 103
ASN Q 104
VAL Q 157
ILE Q  99
 None
 1.02A 1z2bC-5jb3Q:
undetectable		 1z2bC-5jb3Q:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5jb3 30S RIBOSOMAL
PROTEIN S8E
(Pyrococcus
abyssi) 		5 / 11 VAL J  37
THR J  35
ALA J  99
PRO J 114
ALA J 122
 None
 1.26A 2admB-5jb3J:
undetectable		 2admB-5jb3J:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5jb3 30S RIBOSOMAL
PROTEIN S3
(Pyrococcus
abyssi) 		5 / 9 GLN Z 148
GLY Z 127
ILE Z 182
ALA Z 181
VAL Z 180
 None
 1.39A 2drdA-5jb3Z:
4.3		 2drdA-5jb3Z:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5jb3 30S RIBOSOMAL
PROTEIN S2
(Pyrococcus
abyssi) 		5 / 12 PHE B  83
ILE B 116
SER B  71
GLY B  56
LEU B 176
 None
 1.25A 2lbdA-5jb3B:
undetectable		 2lbdA-5jb3B:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 5jb3 30S RIBOSOMAL
PROTEIN S2
(Pyrococcus
abyssi) 		5 / 12 ALA B  60
TYR B 177
GLY B 180
ILE B 190
ALA B 172
 None
 0.96A 2plwA-5jb3B:
undetectable		 2plwA-5jb3B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 5jb3 30S RIBOSOMAL
PROTEIN S9
(Pyrococcus
abyssi) 		4 / 6 LEU K  49
LEU K  46
ILE K  82
ARG K  79
 None
 0.97A 2rlfC-5jb3K:
undetectable
2rlfD-5jb3K:
undetectable		 2rlfC-5jb3K:
18.45
2rlfD-5jb3K:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 5jb3 30S RIBOSOMAL
PROTEIN S3
(Pyrococcus
abyssi) 		5 / 9 ARG Z  13
ILE Z  62
ILE Z  68
PRO Z  78
THR Z  42
 None
 0.99A 3el4B-5jb3Z:
undetectable		 3el4B-5jb3Z:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5jb3 30S RIBOSOMAL
PROTEIN S10
(Pyrococcus
abyssi) 		5 / 10 ALA L  27
ILE L  73
MET L  82
ILE L  96
ILE L  88
 None
 1.08A 3hbbA-5jb3L:
undetectable		 3hbbA-5jb3L:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5jb3 30S RIBOSOMAL
PROTEIN S6E
(Pyrococcus
abyssi) 		4 / 8 GLU G  49
ASN G  46
ASN G  44
ILE G  21
 None
 1.21A 3kp6A-5jb3G:
undetectable
3kp6B-5jb3G:
undetectable		 3kp6A-5jb3G:
22.15
3kp6B-5jb3G:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5jb3 30S RIBOSOMAL
PROTEIN S6E
(Pyrococcus
abyssi) 		4 / 8 GLU G  49
ASN G  48
ASN G  44
ILE G  21
 None
 1.18A 3kp6A-5jb3G:
undetectable
3kp6B-5jb3G:
undetectable		 3kp6A-5jb3G:
22.15
3kp6B-5jb3G:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 5jb3 30S RIBOSOMAL
PROTEIN S10
(Pyrococcus
abyssi) 		5 / 9 ILE L  88
ILE L  85
VAL L  90
ILE L   6
ILE L  96
 None
 1.25A 3p4wB-5jb3L:
undetectable		 3p4wB-5jb3L:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5jb3 30S RIBOSOMAL
PROTEIN S2
(Pyrococcus
abyssi) 		4 / 6 VAL B  17
ASN B 158
TYR B  12
ILE B 154
 None
 1.19A 3q5sA-5jb3B:
undetectable		 3q5sA-5jb3B:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 5jb3 30S RIBOSOMAL
PROTEIN S9
(Pyrococcus
abyssi) 		4 / 8 ILE K  45
LEU K  49
LYS K  23
GLY K  24
 None
None
G  21097 ( 3.7A)
None
 0.93A 3selX-5jb3K:
undetectable		 3selX-5jb3K:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 5jb3 30S RIBOSOMAL
PROTEIN S8E
(Pyrococcus
abyssi) 		5 / 12 LEU J 124
ALA J  63
VAL J 110
ILE J  95
ILE J  78
 None
 0.87A 3so9B-5jb3J:
undetectable		 3so9B-5jb3J:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 5jb3 30S RIBOSOMAL
PROTEIN S8E
(Pyrococcus
abyssi) 		5 / 12 ASN J  64
ALA J  63
VAL J 110
ILE J  95
ILE J  78
 None
 1.05A 3spkB-5jb3J:
undetectable		 3spkB-5jb3J:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 5jb3 30S RIBOSOMAL
PROTEIN S2
(Pyrococcus
abyssi) 		4 / 7 PHE B  83
ALA B  89
THR B  87
LEU B  59
 None
 0.89A 3t3sC-5jb3B:
undetectable		 3t3sC-5jb3B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jb3 30S RIBOSOMAL
PROTEIN S27E
(Pyrococcus
abyssi) 		3 / 3 ARG W  10
LYS W  51
ARG W  12
 G  2 791 ( 4.1A)
C  2 792 ( 4.4A)
None
 1.24A 3w1wA-5jb3W:
undetectable
3w1wB-5jb3W:
undetectable		 3w1wA-5jb3W:
11.63
3w1wB-5jb3W:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jb3 30S RIBOSOMAL
PROTEIN S27E
(Pyrococcus
abyssi) 		3 / 3 ARG W  12
ARG W  10
LYS W  51
 None
G  2 791 ( 4.1A)
C  2 792 ( 4.4A)
 1.20A 3w1wA-5jb3W:
undetectable
3w1wB-5jb3W:
undetectable		 3w1wA-5jb3W:
11.63
3w1wB-5jb3W:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5jb3 30S RIBOSOMAL
PROTEIN S3
(Pyrococcus
abyssi) 		4 / 8 TYR Z 166
VAL Z 180
ILE Z 130
GLU Z  22
 G  21010 ( 4.4A)
None
None
None
 0.95A 4a97D-5jb3Z:
undetectable		 4a97D-5jb3Z:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5jb3 30S RIBOSOMAL
PROTEIN S3
(Pyrococcus
abyssi) 		4 / 7 TYR Z 166
VAL Z 180
ILE Z 130
GLU Z  22
 G  21010 ( 4.4A)
None
None
None
 1.10A 4a97H-5jb3Z:
undetectable		 4a97H-5jb3Z:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5jb3 30S RIBOSOMAL
PROTEIN S3
(Pyrococcus
abyssi) 		4 / 8 TYR Z 166
VAL Z 180
ILE Z 130
GLU Z  22
 G  21010 ( 4.4A)
None
None
None
 1.05A 4a97I-5jb3Z:
undetectable		 4a97I-5jb3Z:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5jb3 30S RIBOSOMAL
PROTEIN S27E
(Pyrococcus
abyssi) 		3 / 3 LYS W   1
LYS W   3
PRO W   4
 None
G  2 608 ( 4.0A)
None
 1.03A 4dv1L-5jb3W:
undetectable		 4dv1L-5jb3W:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 5jb3 30S RIBOSOMAL
PROTEIN S2
(Pyrococcus
abyssi) 		4 / 5 THR B 102
GLN B 125
GLU B 129
THR B 100
 A  21053 ( 3.1A)
A  21053 ( 2.5A)
A  21053 ( 2.9A)
None
 1.27A 4eahA-5jb3B:
undetectable
4eahE-5jb3B:
undetectable
4eahG-5jb3B:
undetectable		 4eahA-5jb3B:
19.10
4eahE-5jb3B:
19.10
4eahG-5jb3B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 5jb3 30S RIBOSOMAL
PROTEIN S9
(Pyrococcus
abyssi) 		4 / 7 ILE K  45
LEU K  49
LYS K  23
GLY K  24
 None
None
G  21097 ( 3.7A)
None
 0.74A 4hbfA-5jb3K:
undetectable		 4hbfA-5jb3K:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 5jb3 30S RIBOSOMAL
PROTEIN S9
(Pyrococcus
abyssi) 		4 / 7 ILE K  45
LEU K  49
LYS K  23
GLY K  24
 None
None
G  21097 ( 3.7A)
None
 0.79A 4hc3A-5jb3K:
undetectable		 4hc3A-5jb3K:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jb3 30S RIBOSOMAL
PROTEIN S3
(Pyrococcus
abyssi) 		5 / 10 LEU Z  99
LEU Z 103
LEU Z 171
ILE Z 130
THR Z 137
 None
 1.30A 4mk4A-5jb3Z:
undetectable		 4mk4A-5jb3Z:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5jb3 30S RIBOSOMAL
PROTEIN S3
(Pyrococcus
abyssi) 		4 / 5 ILE Z  46
VAL Z  54
ILE Z  62
VAL Z  82
 None
 0.66A 4xdtA-5jb3Z:
undetectable		 4xdtA-5jb3Z:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5jb3 30S RIBOSOMAL
PROTEIN S9
(Pyrococcus
abyssi) 		4 / 7 GLY K   8
ARG K 113
GLY K 109
ALA K  77
 None
G  21069 ( 3.7A)
None
None
 0.87A 5e26A-5jb3K:
undetectable
5e26B-5jb3K:
undetectable		 5e26A-5jb3K:
18.44
5e26B-5jb3K:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5jb3 30S RIBOSOMAL
PROTEIN S9
(Pyrococcus
abyssi) 		4 / 7 GLY K   8
ARG K 113
GLY K 109
ALA K  77
 None
G  21069 ( 3.7A)
None
None
 0.89A 5e26C-5jb3K:
undetectable
5e26D-5jb3K:
undetectable		 5e26C-5jb3K:
18.44
5e26D-5jb3K:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5jb3 30S RIBOSOMAL
PROTEIN S9
(Pyrococcus
abyssi) 		4 / 8 ALA K  77
GLY K   8
ARG K 113
GLY K 109
 None
None
G  21069 ( 3.7A)
None
 0.91A 5e26C-5jb3K:
undetectable
5e26D-5jb3K:
undetectable		 5e26C-5jb3K:
18.44
5e26D-5jb3K:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5jb3 30S RIBOSOMAL
PROTEIN S8E
(Pyrococcus
abyssi) 		4 / 4 VAL J 110
ALA J 108
ILE J  77
THR J 103
 None
 1.14A 5e4dB-5jb3J:
undetectable		 5e4dB-5jb3J:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5jb3 30S RIBOSOMAL
PROTEIN S15
(Pyrococcus
abyssi) 		3 / 3 ARG Q  19
VAL Q  26
TRP Q  25
 None
 1.22A 5fvoA-5jb3Q:
undetectable		 5fvoA-5jb3Q:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 5jb3 30S RIBOSOMAL
PROTEIN S15
(Pyrococcus
abyssi) 		5 / 9 ILE Q  81
LEU Q  82
THR Q  47
ILE Q  50
GLY Q  51
 None
None
C  2 704 ( 2.9A)
None
U  2 703 ( 3.0A)
 0.97A 5ifuB-5jb3Q:
undetectable		 5ifuB-5jb3Q:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5jb3 TRANSLATION
INITIATION FACTOR 1A
(Pyrococcus
abyssi) 		3 / 3 GLY 6  44
ASP 6  43
ASN 6  22
 None
 0.47A 5jglA-5jb36:
undetectable		 5jglA-5jb36:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 5jb3 30S RIBOSOMAL
PROTEIN S27E
(Pyrococcus
abyssi) 		4 / 8 VAL W  27
ILE W  58
GLU W  46
ALA W  42
 None
 0.79A 5og9A-5jb3W:
undetectable		 5og9A-5jb3W:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5jb3 30S RIBOSOMAL
PROTEIN S6E
(Pyrococcus
abyssi) 		4 / 5 HIS G  79
ASP G  36
GLY G  35
ASN G 110
 C  21402 ( 3.5A)
None
C  21404 ( 3.7A)
U  21403 ( 2.5A)
 1.25A 5x7pB-5jb3G:
undetectable		 5x7pB-5jb3G:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5jb3 30S RIBOSOMAL
PROTEIN S10
(Pyrococcus
abyssi) 		5 / 12 LEU L  72
VAL L  90
ARG L  71
VAL L  19
ASP L  17
 None
None
G  21112 ( 4.0A)
None
G  21112 ( 4.7A)
 1.25A 6bxlB-5jb3L:
undetectable		 6bxlB-5jb3L:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5jb3 30S RIBOSOMAL
PROTEIN S9
(Pyrococcus
abyssi) 		3 / 3 ARG K 113
ARG K 112
ASP K 110
 G  21069 ( 3.7A)
G  21307 ( 3.1A)
G  21307 ( 2.7A)
 0.97A 6d8pA-5jb3K:
undetectable		 6d8pA-5jb3K:
10.79