SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jbw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 8 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.74A 1v54C-5jbwA:
undetectable
1v54J-5jbwA:
undetectable		 1v54C-5jbwA:
20.91
1v54J-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 10 ILE A 102
ALA A 101
ALA A 100
ALA A 190
ILE A 166
 None
 1.02A 2aclC-5jbwA:
undetectable		 2aclC-5jbwA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 11 ILE A 102
ALA A 101
ALA A 100
ALA A 190
ILE A 166
 None
 1.10A 2aclE-5jbwA:
undetectable		 2aclE-5jbwA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 8 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.74A 2dyrC-5jbwA:
undetectable
2dyrJ-5jbwA:
undetectable		 2dyrC-5jbwA:
20.91
2dyrJ-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 7 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.76A 2eikC-5jbwA:
undetectable
2eikJ-5jbwA:
undetectable		 2eikC-5jbwA:
20.91
2eikJ-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 6 GLU A 183
ALA A 169
PRO A 124
ALA A 168
 None
 1.16A 2zgwB-5jbwA:
undetectable		 2zgwB-5jbwA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 6 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.80A 3abkP-5jbwA:
undetectable
3abkW-5jbwA:
undetectable		 3abkP-5jbwA:
20.91
3abkW-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 8 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.72A 3ag4C-5jbwA:
undetectable
3ag4J-5jbwA:
undetectable		 3ag4C-5jbwA:
20.91
3ag4J-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 7 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.74A 3ag4P-5jbwA:
undetectable
3ag4W-5jbwA:
undetectable		 3ag4P-5jbwA:
20.91
3ag4W-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 7 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.77A 3asnC-5jbwA:
undetectable
3asnJ-5jbwA:
undetectable		 3asnC-5jbwA:
20.91
3asnJ-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 10 ILE A 102
ALA A 101
ALA A 100
ALA A 190
ILE A 166
 None
 1.01A 3falA-5jbwA:
undetectable		 3falA-5jbwA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 10 ILE A 102
ALA A 101
ALA A 100
ALA A 190
ILE A 166
 None
 1.02A 3falC-5jbwA:
undetectable		 3falC-5jbwA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 11 ILE A 102
ALA A 101
ALA A 100
ALA A 190
ILE A 166
 None
 0.97A 3fc6A-5jbwA:
undetectable		 3fc6A-5jbwA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 12 GLU A 132
GLY A 140
GLY A  63
PHE A  88
ARG A 146
 None
 1.29A 3k13A-5jbwA:
undetectable		 3k13A-5jbwA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 11 LEU A 119
ALA A 190
ILE A  14
VAL A  97
ILE A  99
 None
 0.98A 3oxxD-5jbwA:
undetectable		 3oxxD-5jbwA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 7 ASN A 167
ALA A 169
ARG A 155
ARG A 164
 None
 1.12A 3twpA-5jbwA:
undetectable		 3twpA-5jbwA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 6 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.67A 3wg7C-5jbwA:
undetectable
3wg7J-5jbwA:
undetectable		 3wg7C-5jbwA:
20.91
3wg7J-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 7 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.76A 3x2qC-5jbwA:
undetectable
3x2qJ-5jbwA:
undetectable		 3x2qC-5jbwA:
20.91
3x2qJ-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 7 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.85A 3x2qP-5jbwA:
undetectable
3x2qW-5jbwA:
undetectable		 3x2qP-5jbwA:
20.91
3x2qW-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 12 ILE A  17
GLY A  54
ASN A 103
LEU A  34
GLY A 104
 None
 0.85A 4e3aB-5jbwA:
undetectable		 4e3aB-5jbwA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 12 GLY A 110
ALA A  59
ALA A  25
ILE A  26
LEU A 115
 None
 1.16A 5bw4B-5jbwA:
undetectable		 5bw4B-5jbwA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 12 LEU A 119
ALA A 190
ILE A  14
VAL A  97
ILE A  99
 None
 1.05A 5kqyA-5jbwA:
undetectable		 5kqyA-5jbwA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		3 / 3 HIS A 210
SER A  94
ARG A  45
 None
 1.02A 5u63A-5jbwA:
undetectable		 5u63A-5jbwA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 5 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.84A 5x19C-5jbwA:
undetectable
5x19J-5jbwA:
undetectable		 5x19C-5jbwA:
20.91
5x19J-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		4 / 7 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.73A 5x1fP-5jbwA:
undetectable
5x1fW-5jbwA:
undetectable		 5x1fP-5jbwA:
20.91
5x1fW-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 12 ILE A 137
ARG A  69
GLY A  63
ALA A  64
LEU A  66
 None
 1.14A 5zwrA-5jbwA:
undetectable		 5zwrA-5jbwA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 12 ILE A 102
ALA A 101
ALA A 100
ALA A 190
ILE A 166
 None
 1.02A 6a60D-5jbwA:
undetectable		 6a60D-5jbwA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 12 LEU A 128
ILE A 160
THR A 144
VAL A 174
ILE A 166
 None
 1.02A 6emuB-5jbwA:
undetectable		 6emuB-5jbwA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE
(Myxococcus
xanthus) 		5 / 12 LEU A 128
ILE A 160
THR A 144
VAL A 174
ILE A 166
 None
 1.07A 6emuC-5jbwA:
undetectable		 6emuC-5jbwA:
24.00