SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 ASP A  45
ARG A  28
ILE A  20
PRO A 200
ASP A 203
 None
None
None
MG  A 307 (-3.8A)
None
 1.45A 1kijA-5jc8A:
undetectable		 1kijA-5jc8A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A 234
GLY A 232
MET A 231
THR A 237
ASN A  26
 None
 1.07A 1pwyE-5jc8A:
3.0		 1pwyE-5jc8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A 234
GLY A 232
MET A 231
THR A 237
ASN A  26
 None
 1.20A 1v3qE-5jc8A:
2.4		 1v3qE-5jc8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 11 LEU A  95
ILE A 145
ASN A  97
GLY A 175
LEU A 134
 None
 1.38A 2bxeA-5jc8A:
undetectable		 2bxeA-5jc8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 11 LEU A  95
ILE A 145
VAL A 178
GLY A 175
LEU A 134
 None
 1.27A 2bxeA-5jc8A:
undetectable		 2bxeA-5jc8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 5 VAL A  44
VAL A  72
ASP A  71
SER A  77
 None
 1.35A 2x45A-5jc8A:
undetectable		 2x45A-5jc8A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 5 VAL A  44
VAL A  72
ASP A  71
SER A  77
 None
 1.27A 2x45C-5jc8A:
undetectable		 2x45C-5jc8A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A   7
ALA A 245
ALA A 144
VAL A 133
VAL A 146
 None
None
EDO  A 302 (-3.6A)
None
None
 1.13A 3cwkA-5jc8A:
undetectable		 3cwkA-5jc8A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 6 GLY A 234
GLY A 232
MET A 231
ASN A  26
 None
 1.07A 3e9rA-5jc8A:
3.3		 3e9rA-5jc8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 6 GLY A 234
GLY A 232
MET A 231
ASN A  26
 None
 1.10A 3e9rC-5jc8A:
undetectable		 3e9rC-5jc8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		3 / 3 GLY A  18
ASP A  45
ASP A  71
 None
 0.44A 3ou7C-5jc8A:
5.8		 3ou7C-5jc8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		6 / 11 ALA A  29
GLY A  16
GLY A  18
ILE A  30
ASP A  45
ASN A  26
 None
 1.47A 4dcmA-5jc8A:
7.9		 4dcmA-5jc8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 ASP A 236
ASP A 233
ALA A 240
ASP A 260
PRO A 194
 None
 1.43A 4dmgA-5jc8A:
8.2		 4dmgA-5jc8A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_B_SAMB401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 11 ASP A 236
ASP A 233
ALA A 240
ASP A 260
PRO A 194
 None
 1.43A 4dmgB-5jc8A:
7.6		 4dmgB-5jc8A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		3 / 3 LEU A  57
ARG A 235
MET A 231
 None
 0.86A 4m11C-5jc8A:
undetectable		 4m11C-5jc8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 6 SER A 246
GLU A 248
GLY A 175
GLY A 254
 None
 0.67A 5cdnC-5jc8A:
undetectable
5cdnD-5jc8A:
3.0		 5cdnC-5jc8A:
20.91
5cdnD-5jc8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 6 SER A 246
GLU A 248
GLY A 175
GLY A 254
 None
 0.71A 5cdnT-5jc8A:
undetectable
5cdnU-5jc8A:
2.9		 5cdnT-5jc8A:
20.91
5cdnU-5jc8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  25
THR A 199
GLY A 234
PRO A 200
LEU A  55
 MG  A 307 ( 3.7A)
MG  A 307 ( 4.5A)
None
MG  A 307 (-3.8A)
EDO  A 304 (-4.9A)
 1.01A 5ybbA-5jc8A:
5.3		 5ybbA-5jc8A:
19.33