SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jcf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		4 / 6 LEU A 322
VAL A 402
ILE A 433
MET A 306
 None
 1.12A 1opjB-5jcfA:
undetectable		 1opjB-5jcfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 11 LEU A 708
ALA A 725
GLY A 695
ILE A 777
ILE A 761
 None
 0.96A 1t3rB-5jcfA:
undetectable		 1t3rB-5jcfA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 11 GLY A 795
GLY A 325
THR A 324
ILE A 696
CYH A 775
 None
ADP  A1001 (-3.7A)
ADP  A1001 (-4.1A)
None
None
 1.43A 2dr2A-5jcfA:
undetectable		 2dr2A-5jcfA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 LEU A 708
ALA A 725
GLY A 695
ILE A 777
ILE A 761
 None
 1.00A 2hs2B-5jcfA:
undetectable		 2hs2B-5jcfA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 11 LEU A 708
ALA A 725
GLY A 695
ILE A 777
ILE A 761
 None
 0.87A 2idwA-5jcfA:
undetectable		 2idwA-5jcfA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 PHE A 542
ILE A 605
LEU A 708
TYR A 781
ASP A 714
 None
 1.41A 2iyfB-5jcfA:
undetectable		 2iyfB-5jcfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 9 LEU A 708
ALA A 725
GLY A 695
ILE A 777
ILE A 761
 None
 1.03A 2o4pB-5jcfA:
undetectable		 2o4pB-5jcfA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 11 LEU A 708
ALA A 725
GLY A 695
ILE A 777
ILE A 761
 None
 1.04A 3ebzA-5jcfA:
undetectable		 3ebzA-5jcfA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 9 VAL A 331
ILE A 320
GLY A 478
ILE A 434
THR A 336
 None
 1.05A 3el4B-5jcfA:
undetectable		 3el4B-5jcfA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 10 VAL A 331
ILE A 320
GLY A 478
ILE A 434
THR A 336
 None
 1.11A 3el5A-5jcfA:
undetectable		 3el5A-5jcfA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		4 / 6 ILE A 476
TYR A 446
ILE A 433
HIS A 339
 None
 1.10A 3eteA-5jcfA:
undetectable
3eteE-5jcfA:
undetectable		 3eteA-5jcfA:
21.36
3eteE-5jcfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		4 / 5 ILE A 476
TYR A 446
ILE A 433
HIS A 339
 None
 1.09A 3eteB-5jcfA:
undetectable
3eteC-5jcfA:
undetectable		 3eteB-5jcfA:
21.36
3eteC-5jcfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		4 / 7 ILE A 433
HIS A 339
ILE A 476
TYR A 446
 None
 1.09A 3eteD-5jcfA:
undetectable
3eteF-5jcfA:
undetectable		 3eteD-5jcfA:
21.36
3eteF-5jcfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 SER A 423
ASP A 428
ILE A 353
LEU A 410
ARG A 452
 None
 1.24A 3iv6B-5jcfA:
2.9		 3iv6B-5jcfA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		3 / 3 ASN A 357
ASP A 435
ARG A 753
 None
 0.93A 3k13A-5jcfA:
undetectable		 3k13A-5jcfA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		4 / 6 LEU A 322
VAL A 402
ILE A 433
MET A 306
 None
 1.06A 3k5vA-5jcfA:
undetectable		 3k5vA-5jcfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		4 / 6 LEU A 322
VAL A 402
ILE A 433
MET A 306
 None
 1.08A 3k5vB-5jcfA:
undetectable		 3k5vB-5jcfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		4 / 8 THR A 324
SER A 482
HIS A 438
ASN A 357
 ADP  A1001 (-4.1A)
None
None
None
 1.08A 3kp2A-5jcfA:
4.1
3kp2B-5jcfA:
4.2		 3kp2A-5jcfA:
13.25
3kp2B-5jcfA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 ASN A 504
ILE A 319
THR A 480
ILE A 832
ILE A 498
 None
 1.03A 3kpbA-5jcfA:
undetectable		 3kpbA-5jcfA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 11 ILE A 501
THR A 440
ILE A 510
ASN A 317
PRO A 483
 None
 1.25A 3kpcA-5jcfA:
undetectable		 3kpcA-5jcfA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 LEU A 708
ALA A 725
GLY A 695
ILE A 777
ILE A 761
 None
 1.00A 3mwsA-5jcfA:
undetectable		 3mwsA-5jcfA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 9 ILE A 432
ASN A 357
ALA A 407
LEU A 426
VAL A 445
 None
 1.48A 3o01A-5jcfA:
2.4
3o01B-5jcfA:
1.7		 3o01A-5jcfA:
18.40
3o01B-5jcfA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 9 LEU A 322
VAL A 402
ILE A 433
MET A 306
LEU A 301
 None
 1.18A 3oxzA-5jcfA:
undetectable		 3oxzA-5jcfA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 11 LEU A 708
ALA A 725
GLY A 695
ILE A 777
ILE A 761
 None
 0.96A 3oy4A-5jcfA:
undetectable		 3oy4A-5jcfA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 LEU A 708
ALA A 725
GLY A 695
ILE A 777
ILE A 761
 None
 1.03A 3pwmA-5jcfA:
undetectable		 3pwmA-5jcfA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 11 LEU A 708
ALA A 725
GLY A 695
ILE A 777
ILE A 761
 None
 1.03A 3s53B-5jcfA:
undetectable		 3s53B-5jcfA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 VAL A 331
ILE A 320
GLY A 478
ILE A 434
THR A 336
 None
 0.98A 3so9B-5jcfA:
undetectable		 3so9B-5jcfA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		3 / 3 TYR A 671
LEU A 679
LYS A 678
 None
 0.79A 3sueD-5jcfA:
undetectable		 3sueD-5jcfA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		3 / 3 LYS A 514
THR A 512
ILE A 498
 None
 0.94A 4e0fB-5jcfA:
undetectable		 4e0fB-5jcfA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 ILE A 404
LEU A 340
PHE A 370
ILE A 335
VAL A 354
 None
 0.96A 4kfjB-5jcfA:
undetectable		 4kfjB-5jcfA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		3 / 3 LEU A 340
LYS A 337
THR A 336
 None
 0.55A 4lj0A-5jcfA:
undetectable		 4lj0A-5jcfA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 VAL A 331
ILE A 320
GLY A 478
ILE A 434
THR A 336
 None
 1.03A 4njuA-5jcfA:
undetectable		 4njuA-5jcfA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 10 LEU A 708
ALA A 725
GLY A 695
THR A 699
ILE A 761
 None
 1.09A 4njuB-5jcfA:
undetectable		 4njuB-5jcfA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 10 LEU A 708
GLY A 695
ILE A 777
THR A 699
ILE A 761
 None
 1.07A 4njuB-5jcfA:
undetectable		 4njuB-5jcfA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 VAL A 331
ILE A 320
GLY A 478
ILE A 434
THR A 336
 None
 1.03A 4njuC-5jcfA:
undetectable		 4njuC-5jcfA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 10 LEU A 708
ALA A 725
GLY A 695
THR A 699
ILE A 761
 None
 1.08A 4njuD-5jcfA:
undetectable		 4njuD-5jcfA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 10 LEU A 708
GLY A 695
ILE A 777
THR A 699
ILE A 761
 None
 1.07A 4njuD-5jcfA:
undetectable		 4njuD-5jcfA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		4 / 6 GLU A 456
ASP A 428
GLU A 422
ASN A 416
 None
 1.31A 4ntxA-5jcfA:
3.1
4ntxC-5jcfA:
2.5		 4ntxA-5jcfA:
21.77
4ntxC-5jcfA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		4 / 6 GLY A 944
PHE A 962
ILE A 959
PHE A 879
 None
 1.08A 4qogA-5jcfA:
undetectable
4qogB-5jcfA:
undetectable		 4qogA-5jcfA:
15.70
4qogB-5jcfA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		4 / 6 CYH A 936
ILE A 935
GLN A 941
ILE A 888
 ZN  A1003 (-2.3A)
None
None
None
 1.16A 4w5tA-5jcfA:
undetectable		 4w5tA-5jcfA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		3 / 3 THR A 785
ALA A 789
ASN A 786
 G  X   6 ( 4.6A)
None
G  X   6 ( 4.1A)
 0.41A 5ersA-5jcfA:
undetectable		 5ersA-5jcfA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 GLY A 795
GLU A 526
VAL A 524
PRO A 323
GLY A 484
 None
 1.16A 5f9zA-5jcfA:
undetectable		 5f9zA-5jcfA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		5 / 12 VAL A 352
LEU A 301
ASP A 338
GLY A 478
LEU A 479
 None
 1.08A 6b0iB-5jcfA:
undetectable		 6b0iB-5jcfA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Gallus
gallus) 		4 / 6 CYH A 936
ILE A 935
GLN A 941
ILE A 888
 ZN  A1003 (-2.3A)
None
None
None
 1.14A 6cbdA-5jcfA:
1.1		 6cbdA-5jcfA:
21.52