SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jcg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A  40
THR A  44
CYH A  47
ARG A 123
 None
 0.54A 1h4oB-5jcgA:
17.7		 1h4oB-5jcgA:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A  40
THR A  44
CYH A  47
ARG A 123
 None
 0.53A 1h4oG-5jcgA:
17.5		 1h4oG-5jcgA:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASP A  56
PHE A  54
MET A  95
LEU A  99
 None
 0.97A 1lhvA-5jcgA:
undetectable		 1lhvA-5jcgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A  40
THR A  44
CYH A  47
ARG A 123
 None
 0.54A 1oc3A-5jcgA:
17.4		 1oc3A-5jcgA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 124
SER A  72
PHE A  37
ARG A 146
 None
 0.97A 2c8aB-5jcgA:
undetectable		 2c8aB-5jcgA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 SER A 101
LEU A 103
SER A  72
ASP A  42
 None
 1.21A 2j2pE-5jcgA:
undetectable
2j2pF-5jcgA:
undetectable		 2j2pE-5jcgA:
22.63
2j2pF-5jcgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A  40
THR A  44
VAL A  46
ARG A 123
 None
 0.47A 2v32C-5jcgA:
22.4
2v32D-5jcgA:
22.5		 2v32C-5jcgA:
25.65
2v32D-5jcgA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A  40
THR A  44
VAL A  46
ARG A 123
 None
 0.40A 2v41C-5jcgA:
22.6
2v41D-5jcgA:
22.5		 2v41C-5jcgA:
25.65
2v41D-5jcgA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A  40
THR A  44
VAL A  46
ARG A 123
 None
 0.49A 2v41C-5jcgA:
22.6
2v41D-5jcgA:
22.5		 2v41C-5jcgA:
25.65
2v41D-5jcgA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A  40
THR A  44
VAL A  46
ARG A 123
 None
 0.49A 2v41G-5jcgA:
22.3
2v41H-5jcgA:
22.3		 2v41G-5jcgA:
25.65
2v41H-5jcgA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A  36
PHE A  37
LEU A  34
PHE A  29
 None
 1.26A 5xdxC-5jcgA:
undetectable
5xdxJ-5jcgA:
undetectable		 5xdxC-5jcgA:
19.62
5xdxJ-5jcgA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A  69
VAL A  71
ASP A 129
ILE A 134
TYR A 111
 None
 1.35A 6mxtA-5jcgA:
undetectable		 6mxtA-5jcgA:
18.49