SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jcp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_B_DVAB6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		4 / 4 VAL B  79
TRP B  58
ALA B  56
VAL B   9
 None
 1.42A 1gmkA-5jcpB:
undetectable
1gmkB-5jcpB:
undetectable		 1gmkA-5jcpB:
3.05
1gmkB-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.86A 1jnoA-5jcpB:
undetectable		 1jnoA-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.86A 1jnoB-5jcpB:
undetectable		 1jnoB-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.91A 1magA-5jcpB:
undetectable		 1magA-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.91A 1magB-5jcpB:
undetectable		 1magB-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.88A 1ng8A-5jcpB:
undetectable		 1ng8A-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.88A 1ng8B-5jcpB:
undetectable		 1ng8B-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.91A 1nruA-5jcpB:
undetectable		 1nruA-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA B  61
VAL B  11
TRP B  99
 ALF  B1203 ( 4.7A)
None
None
 0.91A 1nruB-5jcpB:
undetectable		 1nruB-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		5 / 12 PHE B1059
PHE B1088
LEU B1031
VAL B 991
PHE B 984
 None
 1.47A 1q23D-5jcpB:
undetectable
1q23E-5jcpB:
undetectable		 1q23D-5jcpB:
18.60
1q23E-5jcpB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		4 / 4 ASP B 975
LEU B 954
LEU B 951
LEU B 953
 None
 1.22A 1u18A-5jcpB:
undetectable		 1u18A-5jcpB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		4 / 8 TYR B 941
THR B1030
THR B1033
VAL B 930
 None
 1.06A 2fb2A-5jcpB:
undetectable		 2fb2A-5jcpB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		4 / 7 TYR B 941
THR B1030
THR B1033
VAL B 930
 None
 1.11A 2fb2B-5jcpB:
undetectable		 2fb2B-5jcpB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU B 980
LEU B1034
ALA B1032
ILE B1035
LEU B 935
 None
 1.03A 2h42C-5jcpB:
undetectable		 2h42C-5jcpB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 LEU B1023
VAL B1087
ARG B1028
 None
 0.81A 3b0wB-5jcpB:
undetectable		 3b0wB-5jcpB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		5 / 12 ARG B 942
GLN B  63
GLY B  12
GLY B  62
ASN B  94
 GDP  B1201 ( 3.4A)
ALF  B1203 (-3.0A)
None
ALF  B1203 (-3.3A)
None
 1.24A 3sxjA-5jcpB:
undetectable		 3sxjA-5jcpB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		5 / 12 ARG B 942
GLN B  63
GLY B  12
GLY B  62
ASN B  94
 GDP  B1201 ( 3.4A)
ALF  B1203 (-3.0A)
None
ALF  B1203 (-3.3A)
None
 1.25A 3sxjB-5jcpB:
undetectable		 3sxjB-5jcpB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		5 / 12 ARG B 942
GLN B  63
GLY B  12
GLY B  62
ASN B  94
 GDP  B1201 ( 3.4A)
ALF  B1203 (-3.0A)
None
ALF  B1203 (-3.3A)
None
 1.25A 3t7sB-5jcpB:
undetectable		 3t7sB-5jcpB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		4 / 6 PHE B1059
LEU B1077
PRO B1061
SER B1062
 None
 1.29A 3vlnA-5jcpB:
2.6		 3vlnA-5jcpB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 LEU B 114
ILE B 151
ARG B 150
 None
 0.66A 4mk4B-5jcpB:
4.0		 4mk4B-5jcpB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		3 / 3 GLN B1078
THR B1052
ASP B1082
 None
 0.79A 5k9dA-5jcpB:
undetectable		 5k9dA-5jcpB:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		4 / 5 LEU B 966
VAL B 964
GLU B 956
LEU B 953
 None
 0.85A 5xooB-5jcpB:
undetectable		 5xooB-5jcpB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		4 / 4 GLY B 934
LEU B 937
VAL B 973
GLU B 974
 None
 1.25A 5yw0A-5jcpB:
undetectable		 5yw0A-5jcpB:
24.14