SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jd0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5jd0 ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE A 919
THR A1030
ARG A 995
LEU A1031
LEU A 996
 None
 1.35A 1eiiA-5jd0A:
undetectable		 1eiiA-5jd0A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jd0 ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A 980
LEU A1034
ALA A1032
ILE A1035
LEU A 935
 None
 1.10A 2h42C-5jd0A:
undetectable		 2h42C-5jd0A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5jd0 ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 7 VAL A1076
ALA A1004
PRO A1061
THR A1066
 None
 1.07A 2q6oA-5jd0A:
undetectable		 2q6oA-5jd0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5jd0 ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 8 TYR A1016
GLN A1042
ILE A1081
SER A1086
 None
 0.79A 2xz5B-5jd0A:
undetectable
2xz5E-5jd0A:
undetectable		 2xz5B-5jd0A:
16.96
2xz5E-5jd0A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5jd0 ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		5 / 12 LEU A 987
GLN A1065
ILE A 922
ARG A 958
LEU A 954
 None
 1.44A 3ia4A-5jd0A:
undetectable		 3ia4A-5jd0A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5jd0 ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		3 / 3 GLN A1078
THR A1052
ASP A1082
 None
 0.79A 5k9dA-5jd0A:
undetectable		 5k9dA-5jd0A:
22.44