SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jd4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 GLY A  88
GLY A  89
GLY A  90
PHE A 209
HIS A 286
 BAM  A 407 ( 3.9A)
BAM  A 407 (-3.4A)
BAM  A 407 (-3.5A)
None
BAM  A 407 (-3.9A)
 0.60A 1dx6A-5jd4A:
17.7		 1dx6A-5jd4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 ALA A 156
GLY A 158
ALA A 183
ILE A 115
PHE A 313
 None
 1.03A 1ve3A-5jd4A:
undetectable		 1ve3A-5jd4A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 ALA A 156
GLY A 158
ALA A 183
ILE A 115
PHE A 313
 None
 1.04A 1ve3B-5jd4A:
undetectable		 1ve3B-5jd4A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 GLY A  88
GLY A  89
GLY A  90
PHE A 209
HIS A 286
 BAM  A 407 ( 3.9A)
BAM  A 407 (-3.4A)
BAM  A 407 (-3.5A)
None
BAM  A 407 (-3.9A)
 0.87A 1w6rA-5jd4A:
17.8		 1w6rA-5jd4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 VAL A  36
ASP A  37
GLY A 164
TYR A 222
TYR A 119
 None
 1.48A 1xvaA-5jd4A:
2.4		 1xvaA-5jd4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		6 / 9 GLY A  89
GLY A  90
ALA A 162
PHE A 218
PHE A 209
HIS A 286
 BAM  A 407 (-3.4A)
BAM  A 407 (-3.5A)
BAM  A 407 (-3.2A)
None
None
BAM  A 407 (-3.9A)
 1.02A 2aceA-5jd4A:
4.6		 2aceA-5jd4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 1.08A 2bm9A-5jd4A:
2.1		 2bm9A-5jd4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 1.08A 2bm9D-5jd4A:
2.5		 2bm9D-5jd4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 0.93A 2br4A-5jd4A:
3.1		 2br4A-5jd4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 0.99A 2br4D-5jd4A:
3.2		 2br4D-5jd4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 1.00A 2br4F-5jd4A:
3.3		 2br4F-5jd4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 8 TYR A 189
GLY A 163
ALA A 161
ALA A 162
 None
None
BAM  A 407 (-3.1A)
BAM  A 407 (-3.2A)
 0.59A 2ej3A-5jd4A:
undetectable		 2ej3A-5jd4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 6 VAL A  36
SER A  40
LEU A 214
HIS A 286
 None
None
None
BAM  A 407 (-3.9A)
 1.23A 2f8dA-5jd4A:
undetectable		 2f8dA-5jd4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 8 TYR A  85
GLU A  44
VAL A  50
TYR A  70
 None
 1.02A 2fl5E-5jd4A:
undetectable
2fl5F-5jd4A:
undetectable		 2fl5E-5jd4A:
21.39
2fl5F-5jd4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 7 GLY A  88
ALA A 161
ALA A 162
PHE A 218
HIS A 286
 BAM  A 407 ( 3.9A)
BAM  A 407 (-3.1A)
BAM  A 407 (-3.2A)
None
BAM  A 407 (-3.9A)
 1.17A 2ha4B-5jd4A:
17.8		 2ha4B-5jd4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 7 GLY A  88
GLY A  89
ALA A 161
ALA A 162
HIS A 286
 BAM  A 407 ( 3.9A)
BAM  A 407 (-3.4A)
BAM  A 407 (-3.1A)
BAM  A 407 (-3.2A)
BAM  A 407 (-3.9A)
 0.91A 2ha4B-5jd4A:
17.8		 2ha4B-5jd4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		6 / 7 GLY A  89
GLY A  90
ALA A 161
ALA A 162
PHE A 218
HIS A 286
 BAM  A 407 (-3.4A)
BAM  A 407 (-3.5A)
BAM  A 407 (-3.1A)
BAM  A 407 (-3.2A)
None
BAM  A 407 (-3.9A)
 1.09A 2ha4B-5jd4A:
17.8		 2ha4B-5jd4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 SER A 290
HIS A  99
TYR A  85
LEU A 106
MET A 186
 None
 1.07A 2prgA-5jd4A:
undetectable		 2prgA-5jd4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 GLN A 185
GLY A 159
GLY A 164
LEU A  83
MET A 309
 None
 1.27A 2zw9A-5jd4A:
3.2		 2zw9A-5jd4A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 6 ILE A 285
ILE A  93
LEU A 295
PHE A 288
 None
 1.02A 3adsA-5jd4A:
undetectable		 3adsA-5jd4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 5jd4 LAE6
(uncultured
bacterium) 		3 / 3 ARG A  66
GLU A  97
TYR A  70
 None
 0.89A 3k37B-5jd4A:
undetectable		 3k37B-5jd4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 5 ARG A 175
LEU A 187
ARG A 268
ILE A 270
 None
 1.17A 3ln1D-5jd4A:
undetectable		 3ln1D-5jd4A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 GLY A 178
ALA A 177
ASP A 176
ARG A 175
ILE A 135
 None
 1.11A 3n3iA-5jd4A:
undetectable		 3n3iA-5jd4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 ALA A 162
GLY A 163
TYR A  86
ALA A 122
PHE A 218
 BAM  A 407 (-3.2A)
None
None
None
None
 1.06A 3qxyA-5jd4A:
undetectable		 3qxyA-5jd4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 11 ALA A 162
GLY A 163
TYR A  86
ALA A 122
PHE A 218
 BAM  A 407 (-3.2A)
None
None
None
None
 1.07A 3qxyB-5jd4A:
undetectable
3qxyQ-5jd4A:
undetectable		 3qxyB-5jd4A:
22.58
3qxyQ-5jd4A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 11 ALA A 162
GLY A 163
TYR A  86
ALA A 122
PHE A 218
 BAM  A 407 (-3.2A)
None
None
None
None
 1.09A 3rc0A-5jd4A:
undetectable		 3rc0A-5jd4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 ALA A 162
GLY A 163
TYR A  86
ALA A 122
PHE A 218
 BAM  A 407 (-3.2A)
None
None
None
None
 1.08A 3rc0B-5jd4A:
undetectable		 3rc0B-5jd4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 5 THR A 252
GLY A 254
PRO A 282
ASN A 280
 None
 1.20A 3u8qA-5jd4A:
undetectable		 3u8qA-5jd4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 HIS A 286
GLY A  90
GLY A  88
TYR A 189
ALA A 122
 BAM  A 407 (-3.9A)
BAM  A 407 (-3.5A)
BAM  A 407 ( 3.9A)
None
None
 1.07A 3vywB-5jd4A:
undetectable		 3vywB-5jd4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 HIS A 286
GLY A  90
GLY A  88
TYR A 189
ALA A 122
 BAM  A 407 (-3.9A)
BAM  A 407 (-3.5A)
BAM  A 407 ( 3.9A)
None
None
 1.02A 3vywD-5jd4A:
undetectable		 3vywD-5jd4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 GLY A 164
ALA A 162
THR A  98
HIS A  99
GLY A  89
 None
BAM  A 407 (-3.2A)
None
None
BAM  A 407 (-3.4A)
 0.81A 4ls7A-5jd4A:
undetectable		 4ls7A-5jd4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 8 MET A 166
ALA A 165
PHE A 289
THR A 102
 None
 1.00A 4ltwA-5jd4A:
undetectable		 4ltwA-5jd4A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 ALA A  59
ASP A 143
ASN A 144
ALA A 137
TYR A  86
 None
 0.88A 4pclA-5jd4A:
3.2		 4pclA-5jd4A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 SER A 290
HIS A  99
TYR A  85
LEU A 106
MET A 186
 None
 1.10A 4xldA-5jd4A:
undetectable		 4xldA-5jd4A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 5 ARG A 233
PRO A 130
ILE A 131
ASP A 132
 None
 1.46A 4z4hA-5jd4A:
4.0		 4z4hA-5jd4A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 11 SER A 290
THR A 102
SER A 116
ALA A 167
GLY A  94
 None
 1.44A 4zjoD-5jd4A:
0.3		 4zjoD-5jd4A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5jd4 LAE6
(uncultured
bacterium) 		3 / 3 ASP A  37
GLU A 124
SER A 290
 None
 0.82A 5bw4B-5jd4A:
undetectable		 5bw4B-5jd4A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 5 HIS A 140
ILE A 117
ILE A 115
TYR A  86
 None
 1.19A 5dnvA-5jd4A:
13.6		 5dnvA-5jd4A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 8 ILE A  84
PHE A 138
VAL A 157
CYH A 171
 None
 0.97A 5dqyA-5jd4A:
1.4		 5dqyA-5jd4A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 LEU A 269
PHE A 242
ILE A 135
THR A 192
ALA A 165
 None
 1.31A 5ienA-5jd4A:
undetectable		 5ienA-5jd4A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 9 PRO A 236
VAL A 169
ILE A 135
ASP A 132
PHE A 127
 None
 1.41A 5tixA-5jd4A:
undetectable		 5tixA-5jd4A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5jd4 LAE6
(uncultured
bacterium) 		3 / 3 TYR A 222
LEU A 121
ASP A  37
 None
 0.85A 5zv2B-5jd4A:
undetectable		 5zv2B-5jd4A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 9 ALA A  45
PHE A 289
GLY A 287
SER A  40
GLY A  43
 PE3  A 406 ( 4.0A)
None
None
None
None
 1.21A 6awoA-5jd4A:
undetectable		 6awoA-5jd4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 9 ALA A  45
PHE A 289
GLY A 287
SER A  40
GLY A  43
 PE3  A 406 ( 4.0A)
None
None
None
None
 1.22A 6awqA-5jd4A:
undetectable		 6awqA-5jd4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 7 ASP A 303
ALA A 307
LYS A 109
LEU A 106
 PE3  A 406 ( 4.6A)
None
None
None
 1.02A 6ci6A-5jd4A:
undetectable		 6ci6A-5jd4A:
13.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IEY_A_CLMA401_0
(ESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		8 / 11 ILE A  93
HIS A  99
ASP A 160
ALA A 161
LEU A 210
HIS A 286
GLY A 287
SER A 290
 None
None
None
BAM  A 407 (-3.1A)
BAM  A 407 (-4.3A)
BAM  A 407 (-3.9A)
None
None
 0.49A 6ieyA-5jd4A:
39.6
6ieyB-5jd4A:
39.7		 6ieyA-5jd4A:
40.91
6ieyB-5jd4A:
40.91