SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 PHE A 259
ALA A 194
GLY A 172
PHE A 201
LEU A  93
 None
None
OAS  A 169 ( 3.1A)
None
None
 1.39A 1brpA-5jd5A:
undetectable		 1brpA-5jd5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		4 / 6 PHE A 158
ARG A  67
ALA A  84
PRO A  88
 None
 1.19A 1oniH-5jd5A:
0.7
1oniI-5jd5A:
undetectable		 1oniH-5jd5A:
18.99
1oniI-5jd5A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 GLY A  97
GLY A  98
GLY A  99
PHE A 228
HIS A 295
 OAS  A 169 ( 4.3A)
OAS  A 169 ( 4.0A)
OAS  A 169 ( 3.0A)
None
OAS  A 169 ( 4.1A)
 0.93A 1qtiA-5jd5A:
3.6		 1qtiA-5jd5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 9 GLY A  98
GLY A  99
ALA A 170
PHE A 228
HIS A 295
 OAS  A 169 ( 4.0A)
OAS  A 169 ( 3.0A)
OAS  A 169 ( 3.6A)
None
OAS  A 169 ( 4.1A)
 0.82A 2aceA-5jd5A:
3.5		 2aceA-5jd5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		3 / 3 ARG A 185
ASP A 142
ASP A  77
 None
 0.87A 2ejtA-5jd5A:
undetectable		 2ejtA-5jd5A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 7 GLY A  98
GLY A  99
ALA A 170
PHE A 228
HIS A 295
 OAS  A 169 ( 4.0A)
OAS  A 169 ( 3.0A)
OAS  A 169 ( 3.6A)
None
OAS  A 169 ( 4.1A)
 0.87A 2ha4B-5jd5A:
16.1		 2ha4B-5jd5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 ALA A 285
GLU A 286
LEU A 287
ARG A 318
ILE A 165
 None
 1.07A 2jfaA-5jd5A:
undetectable		 2jfaA-5jd5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		4 / 7 LEU A 203
TRP A 100
ALA A 170
GLY A 199
 None
None
OAS  A 169 ( 3.6A)
OAS  A 169 ( 3.4A)
 0.92A 2wq5A-5jd5A:
undetectable		 2wq5A-5jd5A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		4 / 8 TYR A 212
ILE A 219
ILE A  29
TYR A 217
 None
 1.00A 2zm8A-5jd5A:
undetectable		 2zm8A-5jd5A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		4 / 8 TYR A 212
ILE A 219
ILE A  29
TYR A 217
 None
 0.99A 2zmaA-5jd5A:
undetectable		 2zmaA-5jd5A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 LEU A 196
GLY A 199
ILE A 165
GLY A 171
GLY A 172
 None
OAS  A 169 ( 3.4A)
None
OAS  A 169 ( 3.8A)
OAS  A 169 ( 3.1A)
 1.09A 3axzA-5jd5A:
undetectable		 3axzA-5jd5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 11 HIS A 186
ARG A 181
ARG A 185
VAL A 151
GLY A 159
 None
 1.32A 3bf6H-5jd5A:
undetectable		 3bf6H-5jd5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		4 / 7 GLY A  98
GLY A  99
LEU A 225
HIS A 295
 OAS  A 169 ( 4.0A)
OAS  A 169 ( 3.0A)
None
OAS  A 169 ( 4.1A)
 0.54A 3o9mA-5jd5A:
3.1		 3o9mA-5jd5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		4 / 6 GLY A  98
GLY A  99
LEU A 225
HIS A 295
 OAS  A 169 ( 4.0A)
OAS  A 169 ( 3.0A)
None
OAS  A 169 ( 4.1A)
 0.55A 3o9mB-5jd5A:
7.8		 3o9mB-5jd5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 TYR A 136
LEU A 203
LEU A 179
ALA A 257
ALA A 194
 None
 1.17A 3vw7A-5jd5A:
undetectable		 3vw7A-5jd5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 GLY A  97
GLY A  98
GLY A  99
PHE A 228
HIS A 295
 OAS  A 169 ( 4.3A)
OAS  A 169 ( 4.0A)
OAS  A 169 ( 3.0A)
None
OAS  A 169 ( 4.1A)
 0.92A 4ey6A-5jd5A:
7.7		 4ey6A-5jd5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 GLY A  97
GLY A  98
GLY A  99
PHE A 228
HIS A 295
 OAS  A 169 ( 4.3A)
OAS  A 169 ( 4.0A)
OAS  A 169 ( 3.0A)
None
OAS  A 169 ( 4.1A)
 0.91A 4ey6B-5jd5A:
15.7		 4ey6B-5jd5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		4 / 6 TRP A 278
ASN A 250
ARG A 277
LEU A 180
 None
 1.21A 4f8yA-5jd5A:
3.0
4f8yB-5jd5A:
2.5		 4f8yA-5jd5A:
16.98
4f8yB-5jd5A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		4 / 6 ALA A 194
ASN A 195
LEU A 196
VAL A 197
 None
 0.90A 4g24A-5jd5A:
undetectable		 4g24A-5jd5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		3 / 3 VAL A  17
SER A  18
THR A  21
 None
 0.47A 4luhA-5jd5A:
undetectable		 4luhA-5jd5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 ALA A 200
GLY A 199
PHE A 198
LEU A 267
GLY A 171
 None
OAS  A 169 ( 3.4A)
OAS  A 169 ( 4.8A)
None
OAS  A 169 ( 3.8A)
 0.91A 4o33A-5jd5A:
undetectable		 4o33A-5jd5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 LEU A 196
GLY A 199
ILE A 165
GLY A 171
GLY A 172
 None
OAS  A 169 ( 3.4A)
None
OAS  A 169 ( 3.8A)
OAS  A 169 ( 3.1A)
 1.08A 4yvgA-5jd5A:
undetectable		 4yvgA-5jd5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 PHE A  95
SER A 125
GLY A 103
GLY A  97
ALA A 105
 None
None
None
OAS  A 169 ( 4.3A)
None
 1.08A 5kpcB-5jd5A:
2.3		 5kpcB-5jd5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 LEU A 316
SER A 116
GLY A 120
GLY A  90
VAL A  91
 None
 1.30A 5o4yD-5jd5A:
undetectable
5o4yE-5jd5A:
undetectable		 5o4yD-5jd5A:
2.54
5o4yE-5jd5A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		5 / 12 PHE A 232
HIS A  96
LEU A 174
LEU A 130
TYR A 128
 None
 1.42A 5y2oA-5jd5A:
undetectable		 5y2oA-5jd5A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5jd5 MGS-MILE3
(uncultured
bacterium) 		4 / 7 ALA A 294
GLY A 293
GLY A 302
ASN A  25
 None
 0.67A 6nm4A-5jd5A:
undetectable		 6nm4A-5jd5A:
19.63