SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5je8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		4 / 6 ILE A 179
ASN A 175
SER A 122
THR A  96
 EPE  A 402 (-4.8A)
None
EPE  A 402 (-3.4A)
NAD  A 401 (-4.0A)
 1.26A 1h7xA-5je8A:
undetectable		 1h7xA-5je8A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		4 / 6 ILE A 179
ASN A 175
SER A 122
THR A  96
 EPE  A 402 (-4.8A)
None
EPE  A 402 (-3.4A)
NAD  A 401 (-4.0A)
 1.27A 1h7xC-5je8A:
2.1		 1h7xC-5je8A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		4 / 6 ILE A 179
ASN A 175
SER A 122
THR A  96
 EPE  A 402 (-4.8A)
None
EPE  A 402 (-3.4A)
NAD  A 401 (-4.0A)
 1.27A 1h7xD-5je8A:
4.1		 1h7xD-5je8A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 11 LEU A  81
GLU A  37
SER A  95
THR A  63
VAL A  61
 None
None
NAD  A 401 (-4.5A)
None
None
 1.13A 1ictA-5je8A:
undetectable
1ictC-5je8A:
undetectable		 1ictA-5je8A:
18.56
1ictC-5je8A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 12 PHE A  91
PHE A  62
ALA A  55
ILE A   4
ILE A 150
 None
 1.07A 2bjfA-5je8A:
undetectable		 2bjfA-5je8A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		4 / 6 PHE A 116
TYR A  75
THR A  63
VAL A  97
 None
 1.10A 2zuhA-5je8A:
undetectable		 2zuhA-5je8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 12 SER A  50
PHE A  82
GLY A  77
TYR A  75
PHE A 116
 None
 1.50A 3a27A-5je8A:
6.6		 3a27A-5je8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 11 LEU A  81
VAL A  89
CYH A  58
PHE A  62
TYR A  75
 None
 0.90A 3bgrA-5je8A:
undetectable
3bgrB-5je8A:
undetectable		 3bgrA-5je8A:
22.30
3bgrB-5je8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 9 TYR A 267
GLY A 180
VAL A 287
GLN A 290
GLY A 185
 None
 1.34A 3kmoA-5je8A:
undetectable		 3kmoA-5je8A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 12 GLY A   8
ASP A  31
LEU A  32
ASN A  33
PRO A  66
 NAD  A 401 ( 3.7A)
NAD  A 401 (-2.7A)
NAD  A 401 (-4.0A)
None
NAD  A 401 (-3.9A)
 0.57A 3q87B-5je8A:
6.1		 3q87B-5je8A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 11 PHE A 135
ASN A 157
GLY A 152
ALA A 118
GLY A 138
 None
 1.35A 4a6nA-5je8A:
4.2		 4a6nA-5je8A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 12 GLY A 124
LEU A 133
ARG A 215
THR A  96
MET A  12
 NAD  A 401 ( 3.5A)
None
None
NAD  A 401 (-4.0A)
NAD  A 401 (-3.5A)
 1.39A 4ojbA-5je8A:
undetectable		 4ojbA-5je8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 12 GLY A 124
LEU A 133
ARG A 215
THR A  96
MET A  12
 NAD  A 401 ( 3.5A)
None
None
NAD  A 401 (-4.0A)
NAD  A 401 (-3.5A)
 1.40A 4okxA-5je8A:
undetectable		 4okxA-5je8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 11 THR A  94
ALA A 119
GLY A 124
GLY A 123
SER A 122
 None
None
NAD  A 401 ( 3.5A)
EPE  A 402 (-3.8A)
EPE  A 402 (-3.4A)
 1.09A 4qvwK-5je8A:
undetectable
4qvwL-5je8A:
undetectable		 4qvwK-5je8A:
23.08
4qvwL-5je8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 11 THR A  94
ALA A 119
GLY A 124
GLY A 123
SER A 122
 None
None
NAD  A 401 ( 3.5A)
EPE  A 402 (-3.8A)
EPE  A 402 (-3.4A)
 1.09A 4qvwY-5je8A:
undetectable
4qvwZ-5je8A:
undetectable		 4qvwY-5je8A:
23.08
4qvwZ-5je8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 12 GLY A   8
GLY A  10
PRO A  15
ASN A  33
LEU A  65
 NAD  A 401 ( 3.7A)
NAD  A 401 (-3.3A)
None
None
NAD  A 401 (-4.9A)
 1.29A 4x61A-5je8A:
2.8		 4x61A-5je8A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 11 TYR A  75
ASP A  93
LEU A  81
VAL A  89
ALA A 119
 None
 1.17A 5d75A-5je8A:
undetectable		 5d75A-5je8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 11 TYR A  75
ASP A  93
LEU A  81
VAL A  89
ALA A 119
 None
 1.16A 5gpgA-5je8A:
undetectable		 5gpgA-5je8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		4 / 8 TYR A  75
VAL A  89
ILE A 165
PHE A  82
 None
 0.91A 5hw8H-5je8A:
undetectable		 5hw8H-5je8A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		4 / 6 THR A 183
GLY A 180
PHE A 181
ILE A 174
 None
 0.83A 5kmfA-5je8A:
1.5
5kmfC-5je8A:
undetectable		 5kmfA-5je8A:
23.40
5kmfC-5je8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 12 SER A  64
THR A  63
LEU A  20
VAL A  27
GLY A   5
 NAD  A 401 (-3.5A)
None
None
None
None
 1.04A 6a94B-5je8A:
2.1		 6a94B-5je8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 12 GLY A   8
GLY A  10
ASN A  33
ALA A  36
LEU A  65
 NAD  A 401 ( 3.7A)
NAD  A 401 (-3.3A)
None
NAD  A 401 ( 4.4A)
NAD  A 401 (-4.9A)
 0.92A 6b3aA-5je8A:
4.4		 6b3aA-5je8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		5 / 12 GLY A   8
GLY A  10
ASN A  33
ALA A  36
LEU A  65
 NAD  A 401 ( 3.7A)
NAD  A 401 (-3.3A)
None
NAD  A 401 ( 4.4A)
NAD  A 401 (-4.9A)
 0.98A 6b3bA-5je8A:
4.4		 6b3bA-5je8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		4 / 6 GLY A  10
LEU A   9
VAL A 121
PHE A  62
 NAD  A 401 (-3.3A)
None
None
None
 1.00A 6h7lA-5je8A:
undetectable		 6h7lA-5je8A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Bacillus
cereus) 		4 / 6 GLY A  10
LEU A   9
VAL A 121
PHE A  62
 NAD  A 401 (-3.3A)
None
None
None
 1.00A 6h7lB-5je8A:
undetectable		 6h7lB-5je8A:
14.24