SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5jem INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		5 / 10 LEU A 245
VAL A 348
VAL A 261
TYR A 210
LEU A 228
 None
 1.33A 1fkoA-5jemA:
undetectable		 1fkoA-5jemA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 5jem INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		3 / 3 GLU A 310
HIS A 290
ASP A 314
 None
 0.68A 1i9gA-5jemA:
undetectable		 1i9gA-5jemA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5jem INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		3 / 3 ARG A 236
VAL A 243
TRP A 241
 None
 1.17A 1qw6A-5jemA:
undetectable		 1qw6A-5jemA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5jem INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		3 / 3 ARG A 236
VAL A 243
TRP A 241
 None
 1.11A 1qwcA-5jemA:
undetectable		 1qwcA-5jemA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5jem INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		3 / 3 ARG A 236
VAL A 243
TRP A 241
 None
 1.19A 1vagA-5jemA:
undetectable		 1vagA-5jemA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5jem INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		3 / 3 ARG A 236
VAL A 243
TRP A 241
 None
 1.18A 1zviA-5jemA:
undetectable		 1zviA-5jemA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5jem INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		6 / 12 GLY A 271
GLY A 270
GLY A 269
LEU A 228
ALA A 273
VAL A 311
 None
 1.44A 4htfA-5jemA:
undetectable		 4htfA-5jemA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jem INTERFERON
REGULATORY FACTOR 3
CREB-BINDING PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU C2096
SER A 336
VAL A 381
GLY A 382
 None
 1.00A 4klrB-5jemC:
undetectable		 4klrB-5jemC:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 5jem CREB-BINDING PROTEIN
INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		4 / 4 LEU C2096
SER C2092
LEU C2067
LEU A 375
 None
 0.93A 4n09A-5jemC:
undetectable		 4n09A-5jemC:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5jem INTERFERON
REGULATORY FACTOR 3
CREB-BINDING PROTEIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLU A 377
ARG A 380
GLN C2082
 None
 0.76A 4rtbA-5jemA:
undetectable		 4rtbA-5jemA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5jem INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		3 / 3 GLU A 310
HIS A 290
ASP A 314
 None
 0.59A 5c0oG-5jemA:
undetectable		 5c0oG-5jemA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5jem INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		3 / 3 ARG A 236
VAL A 243
TRP A 241
 None
 1.13A 5fvoA-5jemA:
undetectable		 5fvoA-5jemA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5jem CREB-BINDING PROTEIN
(Homo
sapiens) 		3 / 3 LEU C2087
GLN C2084
LYS C2065
 None
 0.99A 6exiA-5jemC:
undetectable		 6exiA-5jemC:
16.25