SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jen'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5jen ANTI-SIGMA-V FACTOR
RSIV
(Bacillus
subtilis) 		4 / 7 PHE A  82
SER A 102
ALA A 100
ILE A  80
 None
 1.00A 1fxhA-5jenA:
undetectable
1fxhB-5jenA:
undetectable		 1fxhA-5jenA:
20.58
1fxhB-5jenA:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5jen LYSOZYME C
(Gallus
gallus) 		6 / 6 ASN B  65
ASP B  66
GLY B  67
THR B  69
PRO B  70
SER B  72
 None
None
CL  B 201 (-3.6A)
None
None
NA  B 200 (-2.4A)
 0.41A 1n4fA-5jenB:
26.6		 1n4fA-5jenB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5jen ANTI-SIGMA-V FACTOR
RSIV
(Bacillus
subtilis) 		4 / 8 PHE A  82
SER A 102
ALA A 100
ILE A  80
 None
 0.89A 1pnlA-5jenA:
undetectable
1pnlB-5jenA:
undetectable		 1pnlA-5jenA:
20.58
1pnlB-5jenA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5jen ANTI-SIGMA-V FACTOR
RSIV
LYSOZYME C
(Bacillus
subtilis;
Gallus
gallus) 		5 / 12 ILE B  58
ALA A 167
ALA B  31
LEU B  56
LEU B  17
 None
 1.05A 2h79A-5jenB:
undetectable		 2h79A-5jenB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5jen ANTI-SIGMA-V FACTOR
RSIV
(Bacillus
subtilis) 		5 / 12 PRO A  99
THR A  98
ILE A 162
ASN A 114
LEU A 124
 None
 0.76A 3a50A-5jenA:
undetectable		 3a50A-5jenA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5jen ANTI-SIGMA-V FACTOR
RSIV
(Bacillus
subtilis) 		5 / 12 PRO A  99
THR A  98
ILE A 162
ASN A 114
LEU A 124
 None
 0.86A 3a50E-5jenA:
undetectable		 3a50E-5jenA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5jen ANTI-SIGMA-V FACTOR
RSIV
LYSOZYME C
(Bacillus
subtilis;
Gallus
gallus) 		5 / 11 GLY A 260
GLY A 263
THR A 171
ALA B 110
ALA B  42
 NA  A 401 ( 4.7A)
None
None
None
None
 1.09A 3g89B-5jenA:
undetectable		 3g89B-5jenA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5jen ANTI-SIGMA-V FACTOR
RSIV
LYSOZYME C
(Bacillus
subtilis;
Gallus
gallus) 		5 / 12 GLY A 260
GLY A 263
THR A 171
ALA B 110
ALA B  42
 NA  A 401 ( 4.7A)
None
None
None
None
 1.09A 3g8bB-5jenA:
undetectable		 3g8bB-5jenA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5jen ANTI-SIGMA-V FACTOR
RSIV
LYSOZYME C
(Bacillus
subtilis;
Gallus
gallus) 		5 / 12 ILE B  58
ALA A 167
ALA B  31
LEU B  56
LEU B  17
 None
 1.02A 3gwsX-5jenB:
undetectable		 3gwsX-5jenB:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5jen ANTI-SIGMA-V FACTOR
RSIV
LYSOZYME C
(Bacillus
subtilis;
Gallus
gallus) 		5 / 12 ILE B  58
ALA A 167
ALA B  31
LEU B  56
LEU B  17
 None
 1.00A 3uvvA-5jenB:
undetectable		 3uvvA-5jenB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5jen LYSOZYME C
(Gallus
gallus) 		5 / 11 VAL B  29
ALA B  32
LEU B   8
ILE B 124
LEU B  56
 None
 1.10A 3zosA-5jenB:
undetectable
3zosB-5jenB:
undetectable		 3zosA-5jenB:
18.30
3zosB-5jenB:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 5jen LYSOZYME C
(Gallus
gallus) 		3 / 3 ASN B  46
ASP B  52
ASN B  59
 None
NA  A 401 (-3.1A)
None
 0.55A 4agaA-5jenB:
26.6		 4agaA-5jenB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5jen ANTI-SIGMA-V FACTOR
RSIV
(Bacillus
subtilis) 		3 / 3 TYR A 241
THR A 243
GLU A 147
 None
 0.82A 4df3A-5jenA:
undetectable		 4df3A-5jenA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5jen ANTI-SIGMA-V FACTOR
RSIV
(Bacillus
subtilis) 		3 / 3 TYR A 241
THR A 243
GLU A 147
 None
 0.78A 4df3B-5jenA:
undetectable		 4df3B-5jenA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5jen ANTI-SIGMA-V FACTOR
RSIV
(Bacillus
subtilis) 		4 / 7 ILE A 250
THR A 239
VAL A 200
ASP A 194
 None
NA  A 400 (-3.2A)
None
None
 1.27A 4iarA-5jenA:
undetectable		 4iarA-5jenA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4II8_A_010A210_0
(LYSOZYME C)		 5jen LYSOZYME C
(Gallus
gallus) 		7 / 7 GLU B  35
ASP B  52
GLN B  57
ASN B  59
TRP B  63
ILE B  98
TRP B 108
 NA  A 401 ( 4.2A)
NA  A 401 (-3.1A)
None
None
None
None
None
 0.42A 4ii8A-5jenB:
26.7		 4ii8A-5jenB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 5jen ANTI-SIGMA-V FACTOR
RSIV
LYSOZYME C
(Bacillus
subtilis;
Gallus
gallus) 		5 / 12 ASP A 253
VAL B 109
ALA B 110
GLY A 260
THR A 164
 NA  A 400 ( 3.9A)
None
None
NA  A 401 ( 4.7A)
None
 1.06A 4mm6A-5jenA:
undetectable		 4mm6A-5jenA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 5jen ANTI-SIGMA-V FACTOR
RSIV
LYSOZYME C
(Bacillus
subtilis;
Gallus
gallus) 		5 / 12 ASP A 253
VAL B 109
ALA B 110
GLY A 260
THR A 164
 NA  A 400 ( 3.9A)
None
None
NA  A 401 ( 4.7A)
None
 1.04A 4mm8A-5jenA:
undetectable		 4mm8A-5jenA:
18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DL9_A_ACTA214_0
(LYSOZYME C)		 5jen LYSOZYME C
(Gallus
gallus) 		5 / 5 GLU B  35
ASP B  52
TRP B 108
VAL B 109
ALA B 110
 NA  A 401 ( 4.2A)
NA  A 401 (-3.1A)
None
None
None
 0.52A 5dl9A-5jenB:
26.7		 5dl9A-5jenB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jen ANTI-SIGMA-V FACTOR
RSIV
(Bacillus
subtilis) 		3 / 3 TYR A 170
TYR A 175
SER A 251
 None
 0.80A 5iktB-5jenA:
undetectable		 5iktB-5jenA:
19.25